Airway Secretory IgA Concentrations in Patients with Lung Cancer

Wesselius, Lewis; Dark, Diana S.; Hanson, Fredrick N.; Wheaton, David L.

doi:10.1378/chest.95.6.1265

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…The determination of SIgA in bronchial mucosa can be regarded as a valuable early diagnostic aid for suspected lung tumors [ 130 , 131 ]. The decreased concentration of SIgA in the airway of lung cancer patients may have adverse effects on airway resistance to bacterial colonization [ 132 ].…”

Section: The Relationship Between Siga and Pulmonary Diseasesmentioning

confidence: 99%

SIgA in various pulmonary diseases

Wang,

Zhang,

et al. 2023

Eur J Med Res

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Secretory immunoglobulin A (SIgA) is one of the most abundant immunoglobulin subtypes among mucosa, which plays an indispensable role in the first-line protection against invading pathogens and antigens. Therefore, the role of respiratory SIgA in respiratory mucosal immune diseases has attracted more and more attention. Although the role of SIgA in intestinal mucosal immunity has been widely studied, the cell types responsible for SIgA and the interactions between cells are still unclear. Here, we conducted a wide search of relevant studies and sorted out the relationship between SIgA and some pulmonary diseases (COPD, asthma, tuberculosis, idiopathic pulmonary fibrosis, COVID-19, lung cancer), which found SIgA is involved in the pathogenesis and progression of various lung diseases, intending to provide new ideas for the prevention, diagnosis, and treatment of related lung diseases.

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Section: The Relationship Between Siga and Pulmonary Diseasesmentioning

confidence: 99%

SIgA in various pulmonary diseases

Wang,

Zhang,

et al. 2023

Eur J Med Res

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Role of Bronchoscopy in Lung Cancer Research

Baughman¹,

Pina²

1999

Clinics in Chest Medicine

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Immunoglobulin A levels in bronchial samples during mechanical ventilation and onset of nosocomial pneumonia in critically ill patients.

Annane

Clair²,

Mathieu³

et al. 1996

Am J Respir Crit Care Med

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Local immunoglobulins play a key role in host defense against lung infection. We investigated the pattern of evolution of bronchial albumin, IgA, and IgG levels in ventilated ICU patients in relation to nosocomial pneumonia. Immunocompetent, critically ill patients underwent serial blood and bronchial protein determinations on Day 1 (intubation day), and on Days 3, 7, 10, and 14. The variations in proteins levels were compared with corresponding Day 1 values in the whole population, and between patients who developed lung infections (Group A) and the remaining population (Group B). Forty-four patients were included into the study. In the whole population, when compared with the baseline value, bronchial IgA/albumin ratio increased significantly (Day 3, +58%, p = 0.04); Day 14, +171%, p < 0.01), but serum IgA/albumin and serum and bronchial IgG/albumin ratios did not change significantly. In Group A, the increase in the IgA/albumin ratio was less than in Group B (Day 3, +15% versus +87%, p = 0.04; Day 14, +29% versus +210%, p < 0.01). No significant differences were observed between the two groups for bronchial and plasma albumin and IgG levels and for bronchial polymorphonuclear elastase levels. Bronchial IgA production was enhanced in ventilated patients. A reduction in this enhanced bronchial IgA production might account for the development of nosocomial pneumonia.

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Airway Secretory IgA Concentrations in Patients with Lung Cancer

Cited by 3 publications

References 14 publications

SIgA in various pulmonary diseases

SIgA in various pulmonary diseases

Role of Bronchoscopy in Lung Cancer Research

Immunoglobulin A levels in bronchial samples during mechanical ventilation and onset of nosocomial pneumonia in critically ill patients.

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