Airway Inflammation in COPD Assessed by Sputum Levels of lnterleukin-8*

Yamamoto, Chinaru; Yoneda, Takahiro; Yoshikawa, Masayuki; Fu, Akihiro; Tokuyama, Takeshi; Tsukaguchi, Katsuhiko; Narita, Nobuhiro

doi:10.1378/chest.112.2.505

Cited by 275 publications

(210 citation statements)

References 29 publications

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“…It is a potent chemoattractant for neutrophils and monocytes, and depending on the anatomical location, may contribute to the mobilization of these leukocyte populations into the lung. In some studies, the levels of IL-8 are increased in induced sputum of patients with COPD, and not surprisingly, the levels appear to correlate with the proportion of neutrophils (84), and are also increased in the sputum during exacerbations (85,86).…”

Section: Biomarkers For the Evaluation Of Diseasementioning

confidence: 95%

New Concepts in the Pathobiology of Chronic Obstructive Pulmonary Disease

Kim¹,

Rogers²,

Criner³

2008

Proceedings of the American Thoracic Society

174

120

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Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal persistent inflammatory response to cigarette smoke. This noxious insult leads to emphysema and airway remodeling, manifested by squamous and mucous metaplasia of the epithelium, smooth muscle hypertrophy, and airway wall fibrosis. These pathologic abnormalities interact synergistically to cause progressive airflow obstruction. Although it has been accepted that the spectrum of COPD is vast, the reasons for the development of different phenotypes from the same exposure to cigarette smoke have not been determined. Furthermore, it is becoming increasingly clear that airways disease and emphysema often coexist in many patients, even with a clear clinical phenotype of either emphysema or chronic bronchitis. Recent studies have focused on the nature of the inflammatory response to cigarette smoke, the inflammatory cell lines responsible for COPD pathogenesis, and new biomarkers for disease activity and progression. New cytokines are being discovered, and the complex interactions among them are being unraveled. The inflammatory biomarker that has received the most attention is Creactive protein, but new ones that have caught our attention are interleukin (IL)-6, tumor necrosis factor-a, IL-8, and IL-10. Further research should focus on how these new concepts in lung inflammation interact to cause the various aspects of COPD pathology.

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Section: Biomarkers For the Evaluation Of Diseasementioning

confidence: 95%

New Concepts in the Pathobiology of Chronic Obstructive Pulmonary Disease

Kim¹,

Rogers²,

Criner³

2008

Proceedings of the American Thoracic Society

174

120

View full text Add to dashboard Cite

show abstract

“…As neutrophils comprise the predominant infl ammatory cell in COPD airspaces and, as noted earlier, lymphocytic infi ltrates within lung tissue per se are highly correlated with disease severity, it follows that IL-8 could play a part in the development of emphysema. IL-8 levels are increased in sputum of patients with COPD (Keatings et al 1996;Yamamoto et al 1997), and are further augmented during disease exacerbations, presumably in association with neutrophilic infl ammation triggered by bacteria (Crooks et al 2000;Aaron et al 2001;Gompertz et al 2001). Airway microbes induce IL-8 secretion by epithelial cells, and levels of this cytokine have been shown to correlate with airway bacterial load Patel et al 2002).…”

Section: Interleukin-8 (Il-8)mentioning

confidence: 99%

Role of T-lymphocytes and pro-inflammatory mediators in the pathogenesis of chronic obstructive pulmonary disease

Gadgil

Duncan

2008

COPD

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Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the US and a major worldwide healthcare problem. The pathophysiologic mechanisms that drive development and progression of this disease are complex and only poorly understood. While tobacco smoking is the primary risk factor, other disease processes also appear to play a role. Components of the innate immune system (eg, macrophages and neutrophils) have long been believed to be important in the development of COPD. More recent evidence also suggests involvement of the adaptive immune system in pathogenesis of this disease. Here we will review the literature supporting the participation of T-cells in the development of COPD, and comment on the potential antigenic stimuli that may account for these responses. We will further explore the prospective contributions of T-cell derived mediators that could contribute to the infl ammation, alveolar wall destruction, and small airway fi brosis of advanced COPD. A better understanding of these complex immune processes will lead to new insights that could result in improved preventative and/or treatment strategies.

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“…IL-8 acts as a potent chemoattractant for neutrophils and monocytes to the lung (Barnes, 2009). IL-8 levels are elevated in induced sputum samples from patients with COPD (Keatings et al, 1996) and correlate with the degree of airflow limitation (Yamamoto et al, 1997). The importance of IL-8 levels in COPD disease progression is supported by its potential as a clinical biomarker (Chung, 2006) and the ability of IL-8 receptor antagonists to block pulmonary neutrophil and monocyte recruitment in COPD patients (Barnes, 2008).…”

Section: Introductionmentioning

confidence: 99%