Airway hyperresponsiveness induced by intermittent hypoxia in rats

Low, Tissot; Lin, Tsung-Yen; Lin, Jyun-Yi; Lai, Chiung Ru

doi:10.1016/j.resp.2021.103787

Cited by 6 publications

(2 citation statements)

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“…Clinically, they suggest that local IH can influence inflammatory diseases, such as rhinitis, chronic sinusitis, or even viral infections in the upper airway [ 6 ]. Other authors demonstrated that chronic intermittent hypoxia (CIH) led to bronchial hyperreactivity, increased airway and systemic inflammation, and thus promoted the risk of refractory asthma [ 18 ]. In addition, according to the studies, treatment with p38 MAPK inhibitor substantially decreased the inflammation scores in an asthma mice model [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

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Intermittent Hypoxia on the Attenuation of Induced Nasal Allergy and Allergic Asthma by MAPK Signaling Pathway Downregulation in a Mice Animal Model

Sultonov

Kim²,

Park

et al. 2022

IJMS

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Intermittent hypoxia (IH) has been an issue of considerable research in recent years and triggers a bewildering array of both detrimental and beneficial effects in several physiological systems. However, the mechanisms leading to the effect are not yet clear. Consequently, we investigated the effects of IH on allergen-induced allergic asthma via the mitogen-activated protein kinase (MAPK) signaling pathway. Forty BALB/c mice were dived into four groups. We evaluated the influence of IH on the cell signaling system of the airway during the allergen-induced challenge in an animal model, especially through the MAPK (mitogen-activated protein kinase) pathway. The protein concentrations of p-ERK/ERK, p-JNK/JNK, p-p38/p38, and pMEK/MEK were significantly reduced in the allergen-induced+IH group, compared to the allergen-induced group (p-value < 0.05 as considered statistically significant). The number of eosinophils, neutrophils, macrophages, and lymphocytes in the bronchoalveolar lavage fluid and Dp (Dermatophagoides pteronyssinus)-specific IgG2a and interleukins 4, 5, 13, and 17 were significantly reduced in the Dp+IH group, compared to the Dp group. These findings suggest that the MAPK pathway might be associated with the beneficial effect of IH on the attenuation of allergic response in an allergen-induced mouse model.

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Section: Discussionmentioning

confidence: 99%

“…This effect was found in a 14-day exposure of IH but was not found in the 7-day IH exposure, indicating that time is a major determinant for eliciting a hyperreactive response in the airways. This finding can be elucidated by the hypothesis that different durations of IH exposure provoked different patterns of response [ 18 ].…”

Section: Discussionmentioning

confidence: 99%