Airflow-directed in situ electrospinning of a medical glue of cyanoacrylate for rapid hemostasis in liver resection

Abstract

Rapid hemostasis of solitary organs is still a big challenge in surgical procedures or after major trauma in both civilians and on the battlefield. Here, we report the first use of an airflow-directed in situ electrospinning method to precisely and homogeneously deposit a medical glue of n-octyl-2-cyanoacrylate (OCA) ultrathin fibers onto a wound surface to realize rapid hemostasis in dozens of seconds. In vivo and in vitro experiments on pig liver resection demonstrate that the self-assembled electrospun OCA membrane with high strength, good flexibility and integrity is very compact and no fluid seeping is observed even under a pressure of 147 mm Hg. A similar effect has been achieved in an in vivo experiment on pig lung resection. The results provide a very promising alternative for rapid hemostasis of solitary organs as well as other traumas, providing evidence that the postoperative drainage tube may not be always necessary for surgery in the near future.

Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process

“…To this end, core-shell 74 nanostructures have been very widely studied in the production of functional 75 nanomaterials, including those for biomedical applications [4][5][6]. [19][20][21][22]. The intense research effort invested in these materials thus appears 102 to be about to yield products which can make a major difference to patients' lives.…”

Adhesive Materials for Biomedical Applications

“…In subsequent work [24], it was shown that reinforced specimens were able to withstand twice as many repetitive loading cycles before failure compared with unreinforced specimens. Cyanoacrylate films with a broad range of nanostructured architectures were also created [25]. In order to achieve this, N-octyl-2-cyanocrylate was electrospun and an air pump was used to precisely direct the nanosized polymer fibers to a wound bed.…”

In situ precise electrospinning of medical glue fibers as nonsuture dural repair with high sealing capability and flexibility

“…The apparatus consists of the following four parts: high-voltage power supply, syringe pump, air pump, and a three-way handle spinneret. 33 The handle spinneret is connected to the positive electrode of the high-voltage power supply (DW-P303-1ACFO; Tianjin Dongwen, Tianjin, People's Republic of China), which could provide 6-10 kV voltage to produce fibers. A syringe pump is applied to maintain a stable and precise feeding rate of the electrospun solution.…”