Airborne dermatitis in a child caused by isothiazolinones in a water‐based paint in Italy: Call for better regulations

Sechi, Andrea; Vincenzi, Colombina; Tengattini, Vera; Piraccini, Bianca Maria; Neri, Iria; Plaça, M. La

doi:10.1111/cod.12982

Cited by 11 publications

(12 citation statements)

References 4 publications

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“…Moreover, as it has been stated that 15 ppm MI may not be suitable for preservation, at least if used alone, MI may actually have been replaced by other preservatives in rinse-off cosmetic products. 15 Also spray products can lead to airborne exposure in addition to direct exposure, e.g., by a cleaning spray. In fact, it is not known presently whether 15 ppm when used in rinse-off products, often with repeated and daily exposure, will sufficiently protect from elicitation (and sensitization)the recommendation had been a read-across from evidence of limited, 'tolerable' levels of sensitization after many years of use of MCI/MI at this concentration.…”

Section: Shift In Types Of Products Eliciting Allergic Contact Dermatmentioning

confidence: 99%

“…These include for instance water-based paints 14 which are capable of eliciting severe airborne allergic contact dermatitis. 15 Also spray products can lead to airborne exposure in addition to direct exposure, e.g., by a cleaning spray. 16 Therefore, it has been stressed that the presence of MI should be declared in all products.…”

Section: Shift In Types Of Products Eliciting Allergic Contact Dermatmentioning

confidence: 99%

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The epidemic of methylisothiazolinone contact allergy in Europe: follow‐up on changing exposures

Uter

Aalto‐Korte

Agner

et al. 2019

Acad Dermatol Venereol

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Background Methylisothiazolinone (MI) has caused an unprecedented epidemic of contact allergy in Europe and elsewhere. Subsequently, regulatory action has been taken, at least in Europe, aiming at reducing risk of MI sensitization. Objective To follow‐up on the prevalence of contact allergy to MI in consecutively patch tested patients and assess the spectrum of products containing MI or methylchloroisothiazolinone (MCI)/MI in patients positive to MI which elicited current allergic contact dermatitis. Methods A cross‐sectional survey was performed in 2016 and 2017, including all adult patients patch tested with the baseline series (including MI 0.2% aq.) between 1 May and 31 October at 14 centres in 11 European countries. Patients with positive reactions (+ to +++) to MI were further examined regarding history, clinical characteristics and eliciting products, which were categorized into 34 types and 4 classes (leave‐on, rinse‐off, household, occupational). The results were compared with the reference year 2015. Results A total of 317 patients, n = 202 of 4278 tested in 2016 (4.72%) and n = 115 of 3879 tested in 2017 (2.96%), had positive reactions to MI; the previous result from 2015 was 5.97% (P < 0.0001). The share of currently relevant contact allergy among all positive reactions declined significantly as well (P = 0.0032). Concerning product classes, a relative decline of leave‐on and a relative increase of rinse‐off and household products was noted. Conclusion The prevalence of MI contact allergy decreased by 50% from 2015 to 2017. As a consequence of regulation, the share of cosmetics products (leave‐on in particular) eliciting allergic contact dermatitis is decreasing. The chosen method of analysing causative products in sensitized patients has proven useful to monitor effects of intervention.

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Section: Shift In Types Of Products Eliciting Allergic Contact Dermatmentioning

confidence: 99%

Section: Shift In Types Of Products Eliciting Allergic Contact Dermatmentioning

confidence: 99%

The epidemic of methylisothiazolinone contact allergy in Europe: follow‐up on changing exposures

Uter

Aalto‐Korte

Agner

et al. 2019

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 50%

“…To date, many cases of airborne allergic contact dermatitis secondary to MI in paints have been reported, given the volatile nature of this allergen, and other cases continue to emerge in the literature. 2,3 In our patient, the reaction to MI was significantly stronger than that to methylchloroisothiazolinone/methylisothiazolinone demonstrating that the primary sensitizing agent was MI and not the mixture. In our case the concentration of MI is quite low, and it raises concern about patients already sensitized to MI from cosmetic or household detergents, in whom even very low concentrations may elicit skin reactions following airborne exposure to MI in paints.…”

Section: Discussionmentioning

confidence: 61%

Methylisothiazolinone is still used and undeclared: A paediatric case of airborne contact dermatitis caused by water‐based poster paints for children

et al. 2020

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“…Exposure to these products was occupational or occurred outside the home, and patients therefore had no choice regarding their use. Water‐based paints, the composition of which is, in most cases, not mentioned on the package, are responsible, generally and in our study, for a significant number of sensitizations and relapses . Our patients were not sufficiently aware that MI can be present in the air in recently painted areas, and that there is a risk of an allergic reaction even without direct contact.…”

Section: Discussionmentioning

confidence: 64%

Methylisothiazolinone allergic contact dermatitis: Assessment of relapses in 139 patients after avoidance advice

et al. 2019

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Background Methylisothiazolinone (MI) is a preservative that is responsible for an epidemic of allergic contact dermatitis (ACD). Few studies have been published on the prognosis of patients with MI‐induced ACD. Objectives To evaluate relapses of MI‐induced ACD and difficulties in avoiding MI in patients who had received avoidance advice. Methods A retrospective study of patients with MI‐induced ACD diagnosed in two specialized dermato‐allergology units between 2010 and 2015 was performed. The median follow‐up was 3 years. Results Relapses were observed in 64% of 139 included patients, and were severe in 18%. Rinse‐off cosmetics were responsible for the largest proportion of relapses (27%). The median time to relapse was 5 months. Sixty‐nine per cent of relapses were on the hands, and 29% were on the face. Risk factors for relapsing were hand eczema and a personal history of atopy. The main difficulties encountered in the avoidance strategy were hidden sources of MI, the lack of labelling on industrial products, the complexity of cosmetic labelling, and remembering the name of the allergen. Conclusion MI‐induced ACD has a poor prognosis. Its high rate of relapse is mainly attributable to the difficulties of avoidance. Management needs to be improved. Specialized follow‐up in the year following diagnosis is essential to educate patients.

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Airborne dermatitis in a child caused by isothiazolinones in a water‐based paint in Italy: Call for better regulations

Cited by 11 publications

References 4 publications

The epidemic of methylisothiazolinone contact allergy in Europe: follow‐up on changing exposures

The epidemic of methylisothiazolinone contact allergy in Europe: follow‐up on changing exposures

Methylisothiazolinone is still used and undeclared: A paediatric case of airborne contact dermatitis caused by water‐based poster paints for children

Methylisothiazolinone allergic contact dermatitis: Assessment of relapses in 139 patients after avoidance advice

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