2015
DOI: 10.1378/chest.14-1299
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Air Pollution Exposure

Abstract: Th e interstitial lung diseases (ILDs) comprise a diverse group of entities primarily characterized by the proliferation and thickening of the pulmonary interstitium. Despite a wide range of etiologic processes, many share a common phenotype of irreversible lung fi brosis that, in some patients, leads to progressive hypoxemia, respiratory failure, and death. Inhaled environmental causes have been identifi ed in several well-described forms of ILD, including hypersensitivity pneumonitis, asbestosis, and silicos… Show more

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Cited by 90 publications
(43 citation statements)
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References 58 publications
(53 reference statements)
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“…Experimental studies in animals and humans provide biological plausibility for the association between air pollution and interstitial lung disease, involving oxidative stress, telomere shortening and inflammation mediated by transforming growth factor-β (TGF-β), as shown in a recent review [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…Experimental studies in animals and humans provide biological plausibility for the association between air pollution and interstitial lung disease, involving oxidative stress, telomere shortening and inflammation mediated by transforming growth factor-β (TGF-β), as shown in a recent review [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…Air pollution exposure represents a well-known risk to human health (Johannson et al, 2015) and ecosystems (Wright et al, 2018;Ssebugere et al, 2019). A strong focus on atmospheric air pollution has been developed worldwide which has led to a significant reduction of some contaminants in the atmospheric environment.…”
Section: Introductionmentioning
confidence: 99%
“…Nonetheless, it is important to note that due to the myriad ways in which socioeconomic and environmental factors interact, it is very difficult to establish highly detailed associations of single environmental risk factors with epidemiological outcomes [14][15][16][17]. Moreover, environmental factors rarely occur in isolation; for example, a population can be exposed to a combination of pollutants from different sources, which could result in additive or synergistic effects and symptoms, making medical diagnostic processes extremely cumbersome [1].…”
Section: Environmental Burden Of Diseasementioning
confidence: 99%