Air pollution and risk of hospitalization for epilepsy: the role of farm use of nitrogen fertilizers and emissions of the agricultural air pollutant, nitrous oxide

Fluegge, Keith

doi:10.1590/0004-282x20170107

Cited by 14 publications

(9 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…But in another study conducted in Mexico, a signi cant direct association was observed between O 3 and hospital admission for epilepsy attacks RR = 1.100 (95% CI: 1.025-1.181) (17). In Fluegge et al's study in the USA, no signi cant relation was observed between O 3 and epilepsy attacks (9). In the current study the average concentration of O 3 was 30.…”

Section: Resultscontrasting

confidence: 67%

“…100 (95% CI: 1.025-1.181)(17). In Fluegge et al's study in the USA, no signi cant relation was observed between O 3 and epilepsy attacks(9). In the current study the average concentration of O 3 was 30.21 ± 11.19ppb, which is less that Xu et al's study (mean = 100 ppb ± 63)(11) which showed a negative association, and Cakmak et al's study (mean = 93.26 ppb)(17).…”

mentioning

confidence: 85%

“…Another study from China also shows the possible relation between air pollution and neurodegenerative diseases (8). Fluegge et al reported hospitalization for epilepsy associated with changes in the concentrations of various pollutants including nitrogen dioxides (NO 2 ), carbon monoxide (CO), sulfur dioxide (SO 2 ), ozone (O 3 ), and particulate matter (PM 10 , PM 2.5 ), and showed that air pollutants might be a risk factor for hospital admission for epilepsy (9). However, the effect of air pollution on the central nervous system (CNS) has not been thoroughly studied.…”

Section: Introductionmentioning

confidence: 99%

“…a protective effect for N 2 O in epilepsy IRR = 0.85 (95% CI: 0.74-0.97)(9). N 2 O is a different compound and is derived mainly from agricultural fertilizers and natural sources, but NO 2 is mainly produced by vehicles.Another pollutant evaluated in this study was PM 10 , which had a signi cant relation with epilepsy admission in total and several subgroups, and the strongest relation was found in the under 18 year's subgroup.…”

mentioning

confidence: 98%

See 3 more Smart Citations

Air Pollution and Hospital Admission for Epilepsy in Kerman, Iran

Farahmandfard¹,

Ebrahimi²,

Mirzaee³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: There is little information about air pollution and epilepsy attacks. The aim of this study was to investigate the relation between air pollution and epilepsy admission in Kerman, Iran.Methods: This was an ecological study, in which the concentrations of ambient air pollutants and meteorological data were inquired from the Kerman Environmental Protection Agency and the Kerman Meteorology Organization respectively, and epilepsy admission data were obtained from Kerman’s Shafa hospital Epilepsy Registry. Generalized Additive Models (GAM) with lags up to 7 days were used for estimating the Relative Risks (RR).Results: During 2008 until 2020, 894 epilepsy admission occurred in Kerman which 498 (55.7%) were male. The strongest relation between epilepsy admission was seen in the over 59 years group for CO in lag 0 (RR = 2.1455, 95% CI: 1.5823–2.9091), for NO2 in lag 0 (RR =1.0409, 95% CI: 1.0282–1.0537), and for PM2.5 in lag 5 (RR =1.0157, 95% CI: 1.0062–1.0252). Also for PM10 in the under 18 year's group in lag 2 (RR =1.0064, 95% CI: 1.0029–1.0098), for O3 in lag 0 (RR =0.9671, 95% CI: 0.9581–0.9761) and for SO2 in lag 5 (RR = 0.9937, 95% CI: 0.9891–0.9983).Conclusion: The findings of this study showed that CO, NO2, PM2.5, and PM10 air pollutants might be risk factors for epilepsy admission in Kerman.

show abstract

Section: Resultscontrasting

confidence: 67%

mentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 98%

See 2 more Smart Citations

Air Pollution and Hospital Admission for Epilepsy in Kerman, Iran

Farahmandfard¹,

Ebrahimi²,

Mirzaee³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Fluegge and Fluegge reported hospitalization for epilepsy associated with changes in the concentrations of various pollutants, including nitrogen dioxide (NO 2 ), carbon monoxide (CO), sulfur dioxide (SO 2 ), ozone (O 3 ), and particulate mat-ter (PM). Additionally, Fluegge and Fluegge showed that air pollutants might be a risk factor for epilepsy hospital admissions (9).…”

Section: Introductionmentioning

confidence: 99%

Air Pollution and Hospital Admission for Epilepsy in Kerman, Iran

et al. 2022

View full text Add to dashboard Cite

Background: This study aimed to investigate the relation between air pollution and epilepsy admissions in Kerman, Iran. Methods: In this ecological study, the concentrations of ambient air pollutants and meteorological data were obtained from Kerman Environmental Protection Agency and Kerman Meteorology Organization, respectively. Additionally, epilepsy admission data were obtained from Kerman’s Shafa hospital epilepsy registry. Generalized additive models with lags up to 7 days were used to estimate rate ratios (RRs). Results: Within 2008 to 2020, 894 epilepsy admissions occurred in Kerman, 498 cases (55.7%) of whom were male. The strongest relations of epilepsy admission were observed in the over 59-year group for carbon monoxide (CO) in lag 0 (RR = 2.1455, 95% CI: 1.5823 - 2.9091), nitrogen dioxide (NO2) in lag 0 (RR = 1.0409, 95% CI: 1.0282 - 1.0537), and particulate matter under 2.5 microns (PM2.5) in lag 5 (RR = 1.0157, 95% CI: 1.0062 - 1.0252). There were also significant associations for particulate matter under 10 microns (PM10) in the under 18-year group in lag 2 (RR = 1.0064, 95% CI: 1.0029 - 1.0098), ozone in lag 0 (RR = 0.9671, 95% CI: 0.9581 - 0.9761), and sulfur dioxide in lag 5 (RR = 0.9937, 95% CI: 0.9891 - 0.9983). Conclusions: Exposure to CO, NO2, PM2.5, or PM10 air pollutants might be a risk factor for epilepsy admissions in Kerman. Epilepsy patients should better stay away from exposure to polluted air. Staying at home on polluted days or residing in areas with less air pollution might be an option.

show abstract