Air pollution and Parkinson's disease: A systematic review and meta-analysis up to 2018

Kasdagli, Maria‐Iosifina; Katsouyanni, Klea; Dimakopoulou, Konstantina; Samoli, Evangelia

doi:10.1016/j.ijheh.2018.12.006

Cited by 80 publications

(49 citation statements)

References 47 publications

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“…We also identified diabetes mellitus without/with complications and Parkinson disease as typical minor disease categories that were significantly associated with same-day PM 2.5 in both single- and 2-pollutant models. These results support the growing evidence that acute exposure to air pollution can increase the risk of certain diseases of these organ systems [ 45 – 47 ].…”

Section: Discussionsupporting

confidence: 87%

Ambient air pollution and cause-specific risk of hospital admission in China: A nationwide time-series study

Shi²,

Zhu

et al. 2020

PLoS Med

130

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Background The impacts of air pollution on circulatory and respiratory systems have been extensively studied. However, the associations between air pollution exposure and the risk of noncommunicable diseases of other organ systems, including diseases of the digestive, musculoskeletal, and genitourinary systems, remain unclear or inconclusive. We aimed to systematically assess the associations between short-term exposure to main air pollutants (fine particulate matter [PM 2.5 ] and ozone) and cause-specific risk of hospital admission in China over a wide spectrum of human diseases. Methods and findings Daily data on hospital admissions for primary diagnosis of 14 major and 188 minor disease categories in 252 Chinese cities (107 cities in North China and 145 cities in South China) from January 1, 2013, to December 31, 2017, were obtained from the Hospital Quality Monitoring System of China (covering 387 hospitals in North China and 614 hospitals in South China). We applied a 2-stage analytic approach to assess the associations between air pollution and daily hospital admissions. City-specific associations were estimated with quasi-Poisson regression models and then pooled by random-effects meta-analyses. Each disease category was analyzed separately, and the P values were adjusted for multiple comparisons. A total of 117,338,867 hospital admissions were recorded in the study period. Overall, 51.7% of the hospitalized cases were male, and 71.3% were aged <65 years. Robust positive associations were found between short-term PM 2.5 exposure and hospital

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Section: Discussionsupporting

confidence: 87%

Ambient air pollution and cause-specific risk of hospital admission in China: A nationwide time-series study

Shi²,

Zhu

et al. 2020

PLoS Med

130

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“…In addition, air quality is poorer in urban areas than in rural areas, particularly with respect to fine particulate matter (PM 2.5 ) [72]. Air pollution, particularly from traffic, including PM 2.5 , was associated with increased risk of PD in a recent meta-analysis [73]. Such an association is biologically plausible because urban air pollution has been associated with neuroinflammation and cerebrospinal fluid oligomeric α-synuclein in humans [74,75].…”

Section: Discussionmentioning

confidence: 99%

Well Water and Parkinson’s Disease in Medicare Beneficiaries: A Nationwide Case-Control Study

Silver

Racette

Dube

et al. 2020

JPD

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Background-Well water frequently is considered a risk factor for Parkinson disease (PD), but few studies were designed appropriately to test whether geographic factors affect PD risk. Objective-To determine the risk of PD in relation to residential use of private well water. Methods-In a nationwide, population-based case-control study, we identified all incident PD cases (N=89,790) and all comparable controls (N=21,549,400) age 66-90 who solely relied on Medicare coverage in the U.S. in 2009. We estimated the probability of use of private well water using zip code of residence at diagnosis/reference and U.S. Census data on household water source. We modeled this exposure linearly in logistic regression to calculate the odds ratio (OR) and 95% confidence interval (CI) of PD risk in relation to well water use. We adjusted for age, sex and race/ethnicity, and verified that smoking and use of medical care did not confound results. We repeated analyses with a 2-year exposure lag and separately within each U.S. state. Results-Use of well water was inversely associated with PD risk (OR=0.87, 95% CI 0.85-0.89). We confirmed this association in a Cox survival analysis in which we followed controls for 5 years, death or PD diagnosis. There was little evidence that well water use increased risk of PD in any individual state. Conclusions-Although it remains possible that exposures in well water in more narrow geographic regions increase PD risk, in general these results suggest that exposures more common in urban/suburban areas might also be relevant.

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“…Perhaps counterintuitively, exposure to second-hand smoke was associated with substantially decreased risk of Parkinson’s disease. Accordingly, a further meta-analysis found a slightly higher risk for the incidence of Parkinson’s disease on the basis of 15 studies, resulting in an RRs of 1.06 (95% CI 0.99–1.14) for PM2.5, 1.01 (95% CI 0.98–1.03) for NO 2 , 1.01 (95% CI 1.00–1.02) for O 3 , and 1.34 (95% CI 0.85–2.10) for CO following long-term exposure, while RR for hospital admission due to Parkinson’s disease was 1.03 (95% CI 1.01–1.05) in response to an increase in PM2.5 short-term exposure, with overall high heterogeneity between studies [ 69 ]. Stronger effect estimates for Parkinson’s Disease risk were found in a meta-analysis including 10 studies with RRs of 1.06 (95% CI 1.04–1.09) for NO x , 1.65 (95% CI 1.10–2.48) for CO, 1.01 (95% CI 1.00–1.03) for NO 2 , and 1.01 (95% CI 1.00–1.02) for O 3 , however, there was a high risk of bias [ 70 ].…”

Section: Evidence From Human and Animal Studiesmentioning

confidence: 99%

Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress

Hahad

Lelieveld

Birklein

et al. 2020

IJMS

250

107

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Exposure to ambient air pollution is a well-established determinant of health and disease. The Lancet Commission on pollution and health concludes that air pollution is the leading environmental cause of global disease and premature death. Indeed, there is a growing body of evidence that links air pollution not only to adverse cardiorespiratory effects but also to increased risk of cerebrovascular and neuropsychiatric disorders. Despite being a relatively new area of investigation, overall, there is mounting recent evidence showing that exposure to multiple air pollutants, in particular to fine particles, may affect the central nervous system (CNS) and brain health, thereby contributing to increased risk of stroke, dementia, Parkinson’s disease, cognitive dysfunction, neurodevelopmental disorders, depression and other related conditions. The underlying molecular mechanisms of susceptibility and disease remain largely elusive. However, emerging evidence suggests inflammation and oxidative stress to be crucial factors in the pathogenesis of air pollution-induced disorders, driven by the enhanced production of proinflammatory mediators and reactive oxygen species in response to exposure to various air pollutants. From a public health perspective, mitigation measures are urgent to reduce the burden of disease and premature mortality from ambient air pollution.

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Air pollution and Parkinson's disease: A systematic review and meta-analysis up to 2018

Cited by 80 publications

References 47 publications

Ambient air pollution and cause-specific risk of hospital admission in China: A nationwide time-series study

Ambient air pollution and cause-specific risk of hospital admission in China: A nationwide time-series study

Well Water and Parkinson’s Disease in Medicare Beneficiaries: A Nationwide Case-Control Study

Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress

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