AIEgens for synergistic anticancer therapy

Abstract

Cancer is a mortal disease that can invade other parts of the body and cause severe complications. Despite their continuous progress, conventional cancer therapies including surgery, chemotherapy, and radiation therapy...

Codelivery of CPT and siPHB1 with GSH/ROS Dual-Responsive Hybrid Nanoparticles Based on a [12]aneN3-Derived Lipid for Synergistic Lung Cancer Therapy

“…In general, the performance of traditional fluorogens is highly limited due to the aggregation-caused quenching (ACQ) problem, which blocks their biomedical application. Compared to conventional luminophores, aggregation-induced emission luminogens (AIEgens) exhibited intense fluorescence brightness and extraordinary photostability at relatively high concentrations or in aggregation states, which is particularly beneficial for fluorescence imaging and imaging-guided therapy. , Therefore, the amphiphilic polymer composed of a hydrophobic tetraphenylethene (TPE) derivative and hydrophilic poly­(ethylene glycol) (PEG) linked by a GSH cleavable disulfide bond, TSP , was also successfully prepared. CBN2 was able to effectively condense siRNA into a lipoplex and showed the best anticancer efficiency in A549 cells.…”

Monomer Emission Mechanism Research of Tetraphenylethene Derivative with Supramolecular Self-Assembly in Polymer Microspheres

“…The photophysical phenomenon “aggregation-induced emission” (AIE) was coined by Tang’s group in 2001 and obtained increasing academic interest in various scientific fields ever since . Multifunctional applications constructed from AIE luminogens (AIEgens) have been developed for organic light-emitting diodes (OLEDs), , biomedical imaging, , photothermal therapy, , etc. The AIEgens usually are non-emissive as isolated molecules but emit strongly when aggregated, which is opposite to the aggregation-caused quenching (ACQ) phenomenon .…”