2024
DOI: 10.1021/acsabm.4c00206
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Codelivery of CPT and siPHB1 with GSH/ROS Dual-Responsive Hybrid Nanoparticles Based on a [12]aneN3-Derived Lipid for Synergistic Lung Cancer Therapy

Ya-Xuan Liang,
Xue-Yi Sun,
De-Zhong Xu
et al.

Abstract: The combination of small-interfering RNA (siRNA)-mediated gene silencing and chemotherapeutic agents for lung cancer treatment has attracted widespread attention in terms of a greater therapeutic effect, minimization of systemic toxicity, and inhibition of multiple drug resistance (MDR). In this work, three amphiphiles, CBN1−CBN3, were first designed and synthesized as a camptothecin (CPT) conjugate and gene condensation agents by the combination of aneN 3 ) through the ROS-responsive phenylborate ester and di… Show more

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“…Recently, lipid hybrid nanopolymers with a dual response to GSH/ROS modified with phenylborate ester and disulfide bonds have been newly reported. Due to its small particle size, its stability in blood circulation is significantly prolonged, and its cell inhibition rate reaches 75% through the effective accumulation of the EPR effect at the tumor site . The above dual-response delivery systems provide a direction for us to study tumor drug resistance.…”
Section: Tme-based Stimuli-responsive Rna Delivery Systemsmentioning
confidence: 99%
“…Recently, lipid hybrid nanopolymers with a dual response to GSH/ROS modified with phenylborate ester and disulfide bonds have been newly reported. Due to its small particle size, its stability in blood circulation is significantly prolonged, and its cell inhibition rate reaches 75% through the effective accumulation of the EPR effect at the tumor site . The above dual-response delivery systems provide a direction for us to study tumor drug resistance.…”
Section: Tme-based Stimuli-responsive Rna Delivery Systemsmentioning
confidence: 99%