2022
DOI: 10.1021/acsami.2c05416
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AIEgen Intercalated Nanoclay-Based Photodynamic/Chemodynamic Theranostic Platform for Ultra-Efficient Bacterial Eradication and Fast Wound Healing

Abstract: With the emergence and global spread of bacterial resistance, pathogenic bacterial infections have become a serious threat to human health. Thus, therapeutic strategies with highly antibacterial efficacy and a low tendency to induce drug resistance are strongly desired to combat bacterial infections. Here, an ultra-efficient photodynamic/chemodynamic theranostics platform is developed by intercalating an aggregation-induced emission (AIE) photosensitizer, TPCI, into the nanolayers of iron-bearing montmorilloni… Show more

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Cited by 22 publications
(28 citation statements)
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“…The proven selectivity and sensitivity of the TPE-N­(Ph)-DBT-PH nanosensor reminded us of the challenge of sensing light-independent intracellular 1 O 2 . An MTT assay was performed to analyze the viability of CHO cells to evaluate the cytotoxicity of the TPE-N­(Ph)-DBT-PH nanosensor . As depicted in Figure S31, the viability of CHO cells remains above 90% even after a 48 h treatment by 160 μmol L –1 TPE-N­(Ph)-DBT-PH.…”
Section: Resultsmentioning
confidence: 99%
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“…The proven selectivity and sensitivity of the TPE-N­(Ph)-DBT-PH nanosensor reminded us of the challenge of sensing light-independent intracellular 1 O 2 . An MTT assay was performed to analyze the viability of CHO cells to evaluate the cytotoxicity of the TPE-N­(Ph)-DBT-PH nanosensor . As depicted in Figure S31, the viability of CHO cells remains above 90% even after a 48 h treatment by 160 μmol L –1 TPE-N­(Ph)-DBT-PH.…”
Section: Resultsmentioning
confidence: 99%
“…We investigated the cytotoxicity of the TPE-N­(Ph)-DBT-PH nanosensor through an MTT assay with Chinese hamster ovary (CHO) cells . A 4 × 10 4 cell mL –1 amount of CHO cells was seeded in 96-well plates.…”
Section: Methodsmentioning
confidence: 99%
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“…Photodynamic therapy (PDT) is an emerging alternative to fight against bacteria . Photosensitizers (PSs) could produce reactive oxygen species (ROS) upon light irradiation, which could destroy the structure of the organism (e.g., bacterial membrane) to realize the therapeutic effect. PDT could realize spatiotemporal control treatment, and it efficiently kills bacteria. More importantly, it hardly leads to the drug-resistant bacteria. However, traditional hydrophobic PSs suffer from the aggregation-caused quenching (ACQ) effect in physiologically hydrophilic environments due to the strong π–π stacking interaction.…”
Section: Introductionmentioning
confidence: 99%