AIEgen-based nanoprobe for the ATP sensing and imaging in cancer cells and embryonic stem cells

Efficient fluorescent recognition of ATP/GTP by a water-soluble bisquinolinium pyridine-2,6-dicarboxamide compound. Crystal structures, spectroscopic studies and interaction mode with DNA

“…Fluorescent recognition of ATP/GTP has been dominated by organic articial receptors containing arrays of hydrogen bond donors of NH/CH type or polycationic moieties as binding sites for the polyphosphate fragments. [14][15][16][17][18][19][20][21][22][23][24] Typically, these receptors show binding constants between 10 2 and 10 4 M −1 . 25,26 Consequently, they are suitable to recognize ATP/GTP in the millimolar concentration range, but not signicantly below.…”

Tumor Therapy Strategies Based on Microenvironment‐Specific Responsive Nanomaterials

“…This fluorescent probe for ATP monitoring has been actively used in many research fields. [142] To examine the process of tumor cell growth changes, a 3D microfluidic tumor model was constructed, which was combined with an ATP-reactive mitochondrial probe (AMP) to study TGF-𝛽-induced EMT or glioma stem cells under acidic pH conditions (GSC) metabolic process. The 3D microfluidic model consists of a culture chamber for GSCs and two side channels for the introduction of TGF-𝛽 or an acidic environment, with the middle channel sandwiched in the middle channel filled with Matrigel (Figure 9b).…”

Recent advances in aggregation-induced emission (AIE)-based chemosensors for the detection of organic small molecules

“…163 Kim et al combined TPE with mono-triamine to produce A89 , which can effectively detect ATP in HeLa cells and embryonic stem cells as well. 164 Li et al designed A90 with aptamers and an anthracene derivative fluorogen, which combines with ATP and undergoes confirmation change from a random coil to an antiparallel G-quadruplex (Fig. 14b).…”