AgSbF6-catalyzed efficient propargylation/cycloisomerization tandem reaction for the synthesis of fully substituted furans and new insights into the reaction mechanism

Towards Platinum(II) Complexes forin celluloApplications: Synthesis, Characterization, Biological and Catalytic Evaluation

“…Yet when AgSbF 6 is used in conjunction with Pt complexes, a strong decrease in activity is observed. This can be due to the rapid formation of the Pt hexafluoroantimonate complexes – which appear to be all less active than the corresponding silver salt – and of the inactive AgCl.It is worth noting that Ag(I)‐catalyzed reactions involving the activation of triple bonds has previously been reported in the literature [26–29] …”

Catalyst-Controlled Straightforward Synthesis of Highly Substituted Pyrroles/Furans via Propargylation/Cycloisomerization of α-Oxoketene-N,S-acetals

“…The successful synthesis of highly substituted pyrroles prompted us to consider the synthetic usefulness of propargylated-1,3-dicarbonyl compound 4a , which was formed through the reaction of 1a and 2a in the presence of p -TSA·H 2 O (Table , entry 1). The literature investigation at this stage revealed that the propargylated-1,3-dicarbonyl compounds could be very useful synthons for the construction of highly functionalized furan derivatives via intramolecular cyclization in the presence of base or acid . Hence, we decided to synthesize some propargylated-1,3-dicarbonyl compounds catalyzed by p -TSA·H 2 O and further cyclize them using base to prepare furan.…”

Brønsted Acid–Catalyzed Tandem Reaction of 1,4‐Enediones with 2‐Naphthols: Synthesis of 2‐Furylmethylnaphthalenes

“…[2] Therefore, developing efficient methods for constructing 2furylmethylarene scaffolds has attracted great interest in the organic chemistry community. [3][4][5][6][7][8][9] A literature review reveals that various catalytic synthetic methods toward 2-furylmethylarenes have been developed, resulting in the rapid development of this field. [3][4][5][6][7][8][9][10] Notably, the synthetic methods used to access 2-furylmethylarenes are mainly focused on metal-catalyzed reactions [3][4][5][6][7][8] including transition metal-and Lewis acid-catalyzed reactions, such as gold-catalyzed intramolecular cyclization, [3] copper-catalyzed intermolecular coupling/cyclization, [4] palladium-catalyzed intramolecular cyclization, [5] silver-catalyzed intermolecular addition/ cyclization, [6] and so forth.…”

“…[3][4][5][6][7][8][9] A literature review reveals that various catalytic synthetic methods toward 2-furylmethylarenes have been developed, resulting in the rapid development of this field. [3][4][5][6][7][8][9][10] Notably, the synthetic methods used to access 2-furylmethylarenes are mainly focused on metal-catalyzed reactions [3][4][5][6][7][8] including transition metal-and Lewis acid-catalyzed reactions, such as gold-catalyzed intramolecular cyclization, [3] copper-catalyzed intermolecular coupling/cyclization, [4] palladium-catalyzed intramolecular cyclization, [5] silver-catalyzed intermolecular addition/ cyclization, [6] and so forth. Metal catalysis has obvious advantages such as requiring low catalyst loadings, wide applications, and high selectivity, but transition metal contamination of the products is a potential disadvantage of metal catalysis.…”

“…Among these furan‐related compounds, 2‐furylmethylarenes, a class of α ‐substituted furan derivatives, have been found in some bioactive molecules (Figure 1). [2] Therefore, developing efficient methods for constructing 2‐furylmethylarene scaffolds has attracted great interest in the organic chemistry community [3–9] …”