Agrochemicals in the maternal blood, milk, and cord blood: A source of toxicants for prenates and neonates

Siddiqui, M.K.J.; Saxena, M.; Bhargava, A. K.; Seth, T. D.; Murti, C. R. Krishna; Kutty, D

doi:10.1016/0013-9351(81)90128-6

Cited by 61 publications

(24 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even after the replacement of organochlorine insecticides by organophosphorous insecticides, consumer products like edible crops, fruits, milk and soil show substantial levels of organochlorine pesticide residues. Organochlorine insecticide residues, especially DDT and HCH have been detected in man and his environment (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). High levels of DDT and HCH have been reported in human blood, fat and milk samples in India (12).…”

Section: Introductionmentioning

confidence: 99%

Organochlorine pesticides BHC and DDE in human blood in and around Madurai, India

Subramaniam

Solomon

2006

Indian J Clin Biochem

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Organochlorine pesticides BHC and DDE in human blood in and around Madurai, India

Subramaniam

Solomon

2006

Indian J Clin Biochem

View full text Add to dashboard Cite

show abstract

“…The significance for endogenous ACh metabolism and pesticide toxicity is unknown. Gaining knowledge about the age and genetic differences in this enzyme is especially significant given the role that the cholinergic system plays in learning and memory (51) and the new findings that suggest a role for ACh in various aspects of normal brain development (52)(53)(54) (57,(63)(64)(65)(66)(67)(68)(69). Recognition that many of these compounds are environmentally persistent has resulted in regulatory controls and in generally declining residue levels in humans for polychlorinated biphenyls and DDT.…”

Section: Why Study Mechanisms Ofsusceptibility?mentioning

confidence: 99%

Mechanisms underlying Children's susceptibility to environmental toxicants.

Faustman

Silbernagel

Fenske

et al. 2000

Environ Health Perspect

245

163

View full text Add to dashboard Cite

An important public health challenge has been the need to protect children's health. To accomplish this goal, the scientific community needs scientifically based child-specific risk assessment methods. Critical to their development is the need to understand mechanisms underlying children's sensitivity to environmental toxicants. Risk is defined as the probability of adverse outcome and when applied to environmental risk assessment is usually defined as a function of both toxicity and exposure. To adequately evaluate the potential for enhanced health risks during development, both child-specific factors affecting toxicity and exposure need to be considered. In the first section of this article, example mechanisms of susceptibility relevant for toxicity assessment are identified and discussed. In the second section, examples of exposure factors that help define children's susceptibility are presented. Examples of pesticide research from the newly funded Child Health Center at the University of Washington will be given for illustration. The final section discusses the importance of putting these considerations of children's susceptibility into an overall framework for ascertaining relevancy for human risk assessment. Images Figure 1 Figure 3 Figure 4 Figure 5 Figure 6

show abstract

“…Infants may be more exposed to POPs via their diets because they consume more food and water per unit of body weight and may favour particular foods that could result in higher exposure via those foods such as dairy products (American Academy of Pediatrics 2003). In babies, additional exposures may occur through breastfeeding (Kannan et al 1994;Kannan et al 1997) and placental transfer (Siddiqui et al 1981;Dewan et al 2013). Infants are likely to experience greater exposure to POPs found in indoors, such as PBDEs, because of crawling and mouthing behavior, which results in greater dust ingestion and therefore higher chemical exposure (Cohen Hubal et al 2000).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Assessing infant exposure to persistent organic pollutants via dietary intake in Australia

Toms

Hearn

Mueller

et al. 2016

Food and Chemical Toxicology

View full text Add to dashboard Cite

Persistent organic pollutants (POPs) including polybrominated diphenyl ethers (PBDEs); organochlorine pesticides (OCPs); and polychlorinated biphenyls (PCBs) persist in the environment, bioaccumulate, and pose a risk of causing adverse human health effects. Typically, exposure assessments undertaken by modeling existing intake data underestimate the concentrations of these chemicals in infants. This study

show abstract

Agrochemicals in the maternal blood, milk, and cord blood: A source of toxicants for prenates and neonates

Cited by 61 publications

References 16 publications

Organochlorine pesticides BHC and DDE in human blood in and around Madurai, India

Organochlorine pesticides BHC and DDE in human blood in and around Madurai, India

Mechanisms underlying Children's susceptibility to environmental toxicants.

Assessing infant exposure to persistent organic pollutants via dietary intake in Australia

Contact Info

Product

Resources

About