Agricultural Worker Exposure to and Absorption of Permethrin Applied to Cabbage

Asakawa, Fumiyuki; Jitsunari, Fumihiko; Miki, K.; Choi, Jung Il; Takeda, Noriaki; Kitamado, T; Suna, Shigeru; Manabe, Yoshiki

doi:10.1007/s001289900007

Cited by 23 publications

(10 citation statements)

References 9 publications

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“…Conventional methods for the analysis of OC compounds in fatty samples, and particularly in human adipose tissue, usually involve several steps including extraction, elimination of the fat using acid digestion [20 21], column adsorption chromatography [22 23] or solid phase extraction [24], and analytical determination by GC-ECD or GC-MS.…”

Section: Introductionmentioning

confidence: 99%

Determination of organochlorine compounds in human adipose tissue using automated liquid chromatographic clean up and gas chromatography—tandem mass spectrometry

et al. 2002

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SummaryA multiresidue method based on automated normal-phase LC clean-up and GC-MS-MS analysis has been developed for the determination of organochlorine pesticides and polychlorinated biphenyls in human adipose tissues. Analytes were extracted by dissolving the fat samples in n-hexane, and the hexane extracts were injected onto a silica gel column for automated LC clean-up prior to analysis by GC-MS-MS. The high efficiency of the HPLC clean up for the elimination of fats in combination and the use of GC with tandem mass spectrometry detection gave detection limits at the low ng g 1 concentration level for all analytes using as little as 0.25 g of sample.The overall analytical procedure was applied to several human abdominal fat tissue samples: HCB, 13-HCH, p,p'-DDE and the higher chlorinated PCBs (138, 153 and 180) were the most frequently detected compounds, at levels of 26-1273 ng g 1, 19-933 ng g 1,121 -3945 ng g 1 and 56-496 ng g 1, respectively.

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Section: Introductionmentioning

confidence: 99%

Determination of organochlorine compounds in human adipose tissue using automated liquid chromatographic clean up and gas chromatography—tandem mass spectrometry

et al. 2002

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“…Alegretti et al 23 quantified benzene, toluene and xylenes in whole blood to evaluated extreme exposure in inhalants addicts. Asakawa et al 26 measured the occupational exposure of toluene and xylenes in urine of plastic films industry worker's. Moreover, poor epidemiological data about occupational exposure of Brazilian's shoes workers were found in the literature.…”

Section: Resultsmentioning

confidence: 99%

“…19,23,[26][27][28][29][30][31] However, in all these methods unaltered n-hexane was not included. Furthermore, there is no study dealing with simultaneous determination of unchanged n-hexane, benzene and toluene in blood and/or urine.…”

Section: Introductionmentioning

confidence: 99%

Determination of benzene, toluene and N-hexane in urine and blood by headspace solid-phase microextration/gas-chromatography for the biomonitoring of occupational exposure

Gomes¹,

D'andrea²,

Mendes³

et al. 2010

J. Braz. Chem. Soc.

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A análise de tolueno, benzeno e n-hexano inalterados em urina e sangue humano é uma ferramenta para avaliar a exposição ocupacional a esses solventes. Um método simples usando microextração em fase sólida acoplada ao headspace (HS-SPME), usando fibras de carboxeno/ polidimetilsiloxano (CAR-PDMS) e PDMS, para análise simultânea por cromatografia gasosa de tolueno, benzeno e n-hexano em urina e em sangue foi desenvolvido com intuito de realizar a monitorização biológica de indivíduos expostos ocupacionalmente a esses solventes. O método foi aplicado na análise de amostras de trabalhadores que utilizavam colas, contendo solventes, na recuperação de calçados. O tolueno foi detectado em todas as amostras de sangue coletadas em sapatarias quando se utilizou a fibra de CAR-PDMS (16,0-55,2 mg L ). O benzeno não foi detectado em nenhuma das amostras de sangue e/ou urina. Nenhum dos solventes pode ser quantificado nas amostras de urina.Analysis of unchanged toluene, benzene and n-hexane in human blood and urine can be useful to evaluate occupational exposure to these solvents. A simple method was developed using headspace-solid phase microextraction (HS-SPME) for simultaneous gas-chromatography analysis of toluene, benzene and n-hexane in urine and blood; with purpose of biological monitoring of occupational exposure. Carboxen/polidimethylsiloxane fiber (CAR-PDMS) and PDMS fiber coating were employed in this analysis. Blood and urine samples were collected from handling glue workers. The toluene was detected in all blood samples collected from workers handling glue in shoe repair shops, when using CAR-PDMS fibers (16.0-55.2 mg L -1 , n=7). n-Hexane was only detected in two blood samples (33.0 and 41.3 mg L -1 ) and benzene was not detected in anyone. No solvent could be quantified in urine samples.

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“…Previous studies reported that deltamethrin increases the incidence of lymphomas and thyroid tumors in mice and rats [1] and causes micronucleus induction in mouse bone marrow, as well as genotoxicity in human nasal mucosal cells [2,3] and lymphocytes [4]. Only a few cases of acute toxicity have been reported in occupationally exposed human subjects [5], and metabolism studies in humans have been limited to the detection of primary pyrethroid metabolites in blood or urine [6][7][8]. Our recent data have demonstrated that cispermethrin is poorly metabolized by human liver fractions, although the trans-isomer is readily metabolized by both soluble and microsomal esterases and alcohol and aldehyde dehydrogenases [9].…”

Section: Modification Ofmentioning

confidence: 99%

Abstracts of Posters Presented

Hodgson¹

2007

J Biochem & Molecular Tox

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Agricultural Worker Exposure to and Absorption of Permethrin Applied to Cabbage

Cited by 23 publications

References 9 publications

Determination of organochlorine compounds in human adipose tissue using automated liquid chromatographic clean up and gas chromatography—tandem mass spectrometry

Determination of organochlorine compounds in human adipose tissue using automated liquid chromatographic clean up and gas chromatography—tandem mass spectrometry

Determination of benzene, toluene and N-hexane in urine and blood by headspace solid-phase microextration/gas-chromatography for the biomonitoring of occupational exposure

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