Agreement in endpoints from circadian rhythmometry on healthy human beings living on different continents

SUMMARY1. Unstimulated whole saliva and parotid saliva stimulated at a constant flow rate of 1-0 ml./min were collected from eight subjects at about 07.00, 11.00, 14.00, 17.00 and 22.00 hr and oral temperature was recorded several times daily for time spans of between 4 and 26 days. A leastsquares cosine wave was fitted to the data to test for the presence and characteristics of circadian rhythms. 2. Estimates of mean level, amplitude, acrophase and period were obtained for different components and the results were subjected to cosinor analysis.3. Unstimulated whole saliva showed significant circadian rhythms in flow rate and in the concentrations of sodium and chloride but not in protein, potassium, calcium, phosphate or urea.4. Stimulated parotid saliva showed significant circadian rhythms in the concentrations of protein, sodium, potassium, calcium and chloride but not in phosphate or urea 5. Oral temperature showed a circadian rhythm which, like the salivary rhythms, was of a 24.0 hr periodicity.

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“…2), with the acrophase at 16.41 hr, a value falling in the normal range obtained by other workers (Halberg et al 1969). …”

Section: Discussionsupporting

confidence: 49%

“…The thermometers were calibrated to read in 0 F but in the results, temperature is given as 'C. Halberg, Reinhardt, Bartter, Delea, Gordon, Reinberg, Ghata, Halhuber, Hofmann, Gunther, Knapp, Pena & Garcia-Sainz (1969) have noted the value of recording body temperature as an internal standard in studies of human circadian rhythms.…”

Section: Methodsmentioning

confidence: 99%

Circadian rhythms in human salivary flow rate and composition

Dawes¹

1972

The Journal of Physiology

538

368

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“…A further consequence of this combination of endogenous and masking influences may be that the observed rhythms no longer appear to be phase-locked (Halberg, Reinhardt, Bartter, Delea, Gordon, Reinberg, Ghata, Halhuber, Hoffmann, Gunther, Knapp, Pena & Garcia-Sainz, 1969;Mills, 1974), and dissociation between rhythms (internal dissociation) may be suggested. Such an effect has been reported after real or simulated time zone shifts (Elliott et al 1972;Aschoff, Hoffman, Pohl & Wever, 1975;Klein & Wegmann, 1979) and during shift work (Akerstedt & Froberg, 1975;Chaumont, Laporte, Nicolai & Reinberg, 1979;Vieux, Ghata, Laporte, Migraine, Nicolai & Reinberg, 1979).…”

Section: Discussionmentioning

confidence: 99%

Irregularity of rest and activity: studies on circadian rhythmicity in man.

Minors¹,

Nicholson²,

Spencer³

et al. 1986

The Journal of Physiology

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SUMMARY1. Rectal temperature, electrolyte excretion and performance were studied in young adults who followed an irregular pattern of work and rest for 9 days in an isolation unit.2. In the analysis, effects evoked by the pattern of work and rest were separated from the oscillatory component, and rhythms for individual days were examined by the cosinor method.3. During the schedule, rhythms no longer showed a period of exactly 24 h, and this effect was confirmed by studies using a repeated cycle of irregular work and rest and by studies using constant routines.4. Temperature and urinary constituents differed in the strength and phase of their rhythms when corrected for evoked effects, as well as in the strength of the evoked effects themselves.5. There was evidence of deterioration in performance during work periods which exceeded 9 h, but there was no evidence of progressive deterioration in performance over the 9 day schedule.

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“…over a period of 24 h) rhythms of urinary excretion of many substances in the urine have often been described, both with and without statistical analyses (Bartter, Chan & Simpson, 1979;Conroy & Mills, 1970; Halberg, Reinhardt, Bartter, Delea, Gordon, Reinberg, Ghata, Halhuber, Hofmann, Gunther, Knapp, Pena & Garcia-Sainz, 1969;Mills, 1966;Minors, Mills & Waterhouse, 1976;Wesson, 1964). Under many other circumstances -after time-zone transitions, during shift work and on non-24 h days, reviewed by Minors & Waterhouse (1981) -the circadian rhythms of urinary excretion have given information regarding endogenous and exogenous factors in producing a particular rhythm.…”

Section: Introductionmentioning

confidence: 99%

Circadian rhythms of urinary excretion: the relationship between the amount excreted and the circadian changes.

Minors¹,

Waterhouse²

1982

The Journal of Physiology

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SUMMARY1. The circadian rhythms ofurinary excretion ofwater, sodium, chloride, potassium, urate, calcium and phosphate have been studied in several groups of volunteers.2. These rhythms have been measured: under nychthemeral and constant routine regimens; while subjects were in an Isolation Unit or allowed free egress into society; with spontaneous changes in dietary intake; or after potassium-loading.3. A direct relationship between 24 h mean rate ofexcretion and range ofexcretion was found in all circumstances and for all variables; this relationship was found also when the mesor and amplitude of the cosine curve best describing each 24 h of data were considered.4. These relationships derive from the observation that, with increases in 24 h mean rates of excretion, nocturnal rates increased less than diurnal rates.5. This differential sensitivity as between the night and day times has both endogenous and exogenous components.6. It is suggested that circadian rhythms of urinary excretion result at least partially from this differential sensitivity of the kidney to homeostatic control mechanisms.

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Agreement in endpoints from circadian rhythmometry on healthy human beings living on different continents

Cited by 44 publications

References 0 publications

Circadian rhythms in human salivary flow rate and composition

Circadian rhythms in human salivary flow rate and composition

Irregularity of rest and activity: studies on circadian rhythmicity in man.

Circadian rhythms of urinary excretion: the relationship between the amount excreted and the circadian changes.

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