Agnoprotein of mammalian polyomaviruses

Gerits, Nancy; Moens, Ugo

doi:10.1016/j.virol.2012.05.024

Cited by 46 publications

(45 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Coding mRNAs for these proteins are transcribed later in the infection, initiated by the early T antigens, and like the early proteins are also produced from overlapping coding sequences that are alternatively spliced from a common mRNA. In several members of the mammalian polyomaviruses an additional ‘agnoprotein’ is also expressed, which is thought to be associated with capsid assembly and enhancing viral release [5].…”

Section: Introductionmentioning

confidence: 99%

Identification of a Novel Cetacean Polyomavirus from a Common Dolphin (Delphinus delphis) with Tracheobronchitis

et al. 2013

View full text Add to dashboard Cite

A female short-beaked common dolphin calf was found stranded in San Diego, California in October 2010, presenting with multifocal ulcerative lesions in the trachea and bronchi. Viral particles suggestive of polyomavirus were detected by EM, and subsequently confirmed by PCR and sequencing. Full genome sequencing (Ion Torrent) revealed a circular dsDNA genome of 5,159 bp that was shown to form a distinct lineage within the genus Polyomavirus based on phylogenetic analysis of the early and late transcriptomes. Viral infection and distribution in laryngeal mucosa was characterised using in-situ hybridisation, and apoptosis observed in the virus-infected region. These results demonstrate that polyomaviruses can be associated with respiratory disease in cetaceans, and expand our knowledge of their diversity and clinical significance in marine mammals.

show abstract

Section: Introductionmentioning

confidence: 99%

Identification of a Novel Cetacean Polyomavirus from a Common Dolphin (Delphinus delphis) with Tracheobronchitis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…T-Ag and t-Ag are transcribed early in infection. In a few mammalian polyomaviruses and some avian polyomaviruses, an additional ORF is expressed (VP4) that is thought to play a role in capsid assembly and release (Gerits & Moens, 2012).…”

mentioning

confidence: 99%

Identification of an avian polyomavirus associated with Adélie penguins (Pygoscelis adeliae)

Varsani

Porzig

Jennings

et al. 2015

Journal of General Virology

View full text Add to dashboard Cite

“…Conversely, even the largest ORF with 43 amino acids, is smaller than the already known agnoproteins, except for the putative Myotis polyomavirus agnoprotein, which is only 30 amino acids long [18]. Nonetheless, the basic nature and the genomic position are consistent with that of a mammalian polyomavirus agnoprotein [34]. Further research will be necessary to confirm whether one of the 3 putative agnoproteins is expressed and whether it is fully functional.…”

Section: Resultsmentioning

confidence: 99%

Characterization of a Novel Polyomavirus Isolated from a Fibroma on the Trunk of an African Elephant (Loxodonta africana)

et al. 2013

View full text Add to dashboard Cite

Viruses of the family Polyomaviridae infect a wide variety of avian and mammalian hosts with a broad spectrum of outcomes including asymptomatic infection, acute systemic disease, and tumor induction. In this study a novel polyomavirus, the African elephant polyomavirus 1 (AelPyV-1) found in a protruding hyperplastic fibrous lesion on the trunk of an African elephant (Loxodonta africana) was characterized. The AelPyV-1 genome is 5722 bp in size and is one of the largest polyomaviruses characterized to date. Analysis of the AelPyV-1 genome reveals five putative open-reading frames coding for the classic small and large T antigens in the early region, and the VP1, VP2 and VP3 capsid proteins in the late region. In the area preceding the VP2 start codon three putative open-reading frames, possibly coding for an agnoprotein, could be localized. A regulatory, non-coding region separates the 2 coding regions. Unique for polyomaviruses is the presence of a second 854 bp long non-coding region between the end of the early region and the end of the late region. Based on maximum likelihood phylogenetic analyses of the large T antigen of the AelPyV-1 and 61 other polyomavirus sequences, AelPyV-1 clusters within a heterogeneous group of polyomaviruses that have been isolated from bats, new world primates and rodents.

show abstract

Agnoprotein of mammalian polyomaviruses

Cited by 46 publications

References 114 publications

Identification of a Novel Cetacean Polyomavirus from a Common Dolphin (Delphinus delphis) with Tracheobronchitis

Identification of a Novel Cetacean Polyomavirus from a Common Dolphin (Delphinus delphis) with Tracheobronchitis

Identification of an avian polyomavirus associated with Adélie penguins (Pygoscelis adeliae)

Characterization of a Novel Polyomavirus Isolated from a Fibroma on the Trunk of an African Elephant (Loxodonta africana)

Contact Info

Product

Resources

About