Identification of an avian polyomavirus associated with Adélie penguins (Pygoscelis adeliae)

Varsani, Arvind; Porzig, Elizabeth L.; Jennings, Scott; Kraberger, Simona; Farkas, Kata; Julian, Laurel; Massaro, Melanie; Ballard, Grant; Ainley, David G.

doi:10.1099/vir.0.000038

Cited by 44 publications

(29 citation statements)

References 49 publications

(41 reference statements)

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“…Therefore, the absence of reads from these virus families is not due to a lack of sensitivity, but reflects a true absence of these families as resident viruses on the chicken skin, in contrast to human skin. It is remarkable that only four Papillomaviridae have been described in birds to date (Psittacus erithacus PePV1, Fringilla coelebs FcPV1, Francolinus leucosceptus* FlPV1, and Pygoscelis adeliae papillomavirus 1 PaCV1), none of which infecting the Gallus gallus species [35,36], whereas more than 160 have been found in humans. Regarding Polyomaviridae, five have been identified in birds but not in chickens, whereas thirteen have been found in humans, eleven of which were found since 2007, mostly by HTS methods [37].…”

Section: Discussionmentioning

confidence: 98%

Chicken skin virome analyzed by high-throughput sequencing shows a composition highly different from human skin

Denesvre¹,

Dumarest

Rémy³

et al. 2015

Virus Genes

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Recent studies show that human skin at homeostasis is a complex ecosystem whose virome include circular DNA viruses, especially papillomaviruses and polyomaviruses. To determine the chicken skin virome in comparison with human skin virome, a chicken swabs pool sample from fifteen indoor healthy chickens of five genetic backgrounds was examined for the presence of DNA viruses by high-throughput sequencing (HTS). The results indicate a predominance of herpesviruses from the Mardivirus genus, coming from either vaccinal origin or presumably asymptomatic infection. Despite the high sensitivity of the HTS method used herein to detect small circular DNA viruses, we did not detect any papillomaviruses, polyomaviruses, or circoviruses, indicating that these viruses may not be resident of the chicken skin. The results suggest that the turkey herpesvirus is a resident of chicken skin in vaccinated chickens. This study indicates major differences between the skin viromes of chickens and humans. The origin of this difference remains to be further studied in relation with skin physiology, environment, or virus population dynamics.

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Section: Discussionmentioning

confidence: 98%

Chicken skin virome analyzed by high-throughput sequencing shows a composition highly different from human skin

Denesvre¹,

Dumarest

Rémy³

et al. 2015

Virus Genes

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show abstract

“…Avian polyomaviruses are known to cause inflammatory disease in birds, and can lead to disease of the skin and feathers and mortality in some species. The first polyomavirus identified in Antarctica was found in the feces of Adélie penguins at Cape Royds, Ross Island (Varsani et al, 2015) using a HTS-informed approach. Analysis of this genome shows that it falls in the avian polyomavirus lineage, representing a novel species (Pygoscelis adeliae polyomavirus 1).…”

Section: Polyomaviridaementioning

confidence: 99%

Viruses associated with Antarctic wildlife: From serology based detection to identification of genomes using high throughput sequencing

2018

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The Antarctic, sub-Antarctic islands and surrounding sea-ice provide a unique environment for the existence of organisms. Nonetheless, birds and seals of a variety of species inhabit them, particularly during their breeding seasons. Early research on Antarctic wildlife health, using serology-based assays, showed exposure to viruses in the families Birnaviridae, Flaviviridae, Herpesviridae, Orthomyxoviridae and Paramyxoviridae circulating in seals (Phocidae), penguins (Spheniscidae), petrels (Procellariidae) and skuas (Stercorariidae). It is only during the last decade or so that polymerase chain reaction-based assays have been used to characterize viruses associated with Antarctic animals. Furthermore, it is only during the last five years that full/whole genomes of viruses (adenoviruses, anelloviruses, orthomyxoviruses, a papillomavirus, paramyoviruses, polyomaviruses and a togavirus) have been sequenced using Sanger sequencing or high throughput sequencing (HTS) approaches. This review summaries the knowledge of animal Antarctic virology and discusses potential future directions with the advent of HTS in virus discovery and ecology.

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“…Adélie penguin ( Pygoscelis adeliae ), Chinstrap penguins ( Pygoscelis antarctica ) and Gentoo penguins ( Pygoscelis papua ), including an adenovirus, paramyxoviruses, orthomyxoviruses, a polyomavirus and a papillomavirus (Thomazelli et al 2010; Hurt et al 2014, 2016; Lee et al 2014, 2016; Varsani et al 2014, 2015). Similarly, a polyomavirus has been identified in sharp-spined notothen ( Trematomus pennelii ), an Antarctic fish (Buck et al 2016), a parapoxvirus (Tryland et al 2005) and a polyomavirus (Varsani et al 2017) in Weddell seals ( Leptonychotes weddellii ), and an adenovirus has been identified in South Polar skua ( Stercorarius maccormicki ) (Park et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Diverse and highly recombinant anelloviruses associated with Weddell seals in Antarctica

et al. 2017

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The viruses circulating among Antarctic wildlife remain largely unknown. In an effort to identify viruses associated with Weddell seals (Leptonychotes weddellii) inhabiting the Ross Sea, vaginal and nasal swabs, and faecal samples were collected between November 2014 and February 2015. In addition, a Weddell seal kidney and South Polar skua (Stercorarius maccormicki) faeces were opportunistically sampled. Using high throughput sequencing, we identified and recovered 152 anellovirus genomes that share 63–70% genome-wide identities with other pinniped anelloviruses. Genome-wide pairwise comparisons coupled with phylogenetic analysis revealed two novel anellovirus species, tentatively named torque teno Leptonychotes weddellii virus (TTLwV) -1 and -2. TTLwV-1 (n = 133, genomes encompassing 40 genotypes) is highly recombinant, whereas TTLwV-2 (n = 19, genomes encompassing three genotypes) is relatively less recombinant. This study documents ubiquitous TTLwVs among Weddell seals in Antarctica with frequent co-infection by multiple genotypes, however, the role these anelloviruses play in seal health remains unknown.

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Identification of an avian polyomavirus associated with Adélie penguins (Pygoscelis adeliae)

Cited by 44 publications

References 49 publications

Chicken skin virome analyzed by high-throughput sequencing shows a composition highly different from human skin

Chicken skin virome analyzed by high-throughput sequencing shows a composition highly different from human skin

Viruses associated with Antarctic wildlife: From serology based detection to identification of genomes using high throughput sequencing

Diverse and highly recombinant anelloviruses associated with Weddell seals in Antarctica

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