2016
DOI: 10.1016/j.ajme.2015.09.001
|View full text |Cite
|
Sign up to set email alerts
|

Agmatine inhibits nuclear factor-κB nuclear translocation in acute spinal cord compression injury rat model

Abstract: Secondary damage after acute spinal cord compression injury (SCCI) exacerbates initial insult. Nuclear factor kappa-B (NF-jB)-p65 activation is involved in SCCI deleterious effects. Agmatine (Agm) showed neuroprotection against various CNS injuries. However, Agm impact on NF-jB signaling in acute SCCI remains to be investigated. The present study compared the effectiveness of Agm therapy and decompression laminectomy (DL) in functional recovery, oxidative stress, inflammatory and apoptotic responses, and modul… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(2 citation statements)
references
References 46 publications
(63 reference statements)
0
2
0
Order By: Relevance
“…Other studies showed that administration of AGM has partially attenuated oxidative damage in liver injury after Chlorpromazine (CPZ) hepatotoxicity of the Wistar rat's model [17]. Furthermore, it effectively inhibited nuclear factor kappa-B (NF-κB) the cardinal transcription factor, which leads to suppressing the mediator of inflammation such as tumor necrosis factor-α (TNF-α) [18]. This data confirmed its role as a potent anti-inflammatory drug [7].…”
Section: Introductionmentioning
confidence: 69%
“…Other studies showed that administration of AGM has partially attenuated oxidative damage in liver injury after Chlorpromazine (CPZ) hepatotoxicity of the Wistar rat's model [17]. Furthermore, it effectively inhibited nuclear factor kappa-B (NF-κB) the cardinal transcription factor, which leads to suppressing the mediator of inflammation such as tumor necrosis factor-α (TNF-α) [18]. This data confirmed its role as a potent anti-inflammatory drug [7].…”
Section: Introductionmentioning
confidence: 69%
“…These data reveal that AGM has excellent protective properties against inflammatory response. The antiinflammatory effects of AGM seem to be mediated through inhibiting the secretion of cytokines from inflammatory cells and the suppression of the NFkB signaling as the primary pathway involved in the inflammatory response [45,46]. On the other hand, this neuro-amine could tremendously mitigate oxidative stress and neuronal damage with various pathologies [46][47][48][49].…”
Section: Introductionmentioning
confidence: 99%