Agitation en réanimation : penser au syndrome de sevrage nicotinique

Tran-Van, David; Herve, Y.; Labadie, P; Deroudilhe, Gilles; Avarguès, P.

doi:10.1016/j.annfar.2004.02.046

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…The delirium developed 2-10 days after smoking cessation, and either completely resolved or substantially improved following NRT. In another report, Tran-Van et al 10 described a subject with restlessness and difficulty being weaned from mechanical ventilation, which was attributed to nicotine withdrawal. The patient's condition improved following NRT.…”

Section: Discussionmentioning

confidence: 99%

Outcome of Nicotine Replacement Therapy in Patients Admitted to ICU: A Randomized Controlled Double-Blind Prospective Pilot Study

Pathak

Rendon²,

Lupu³

et al. 2013

Respir Care

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BACKGROUND:The effect of nicotine withdrawal in smokers admitted to the ICU is not well understood, so the role of nicotine replacement therapy (NRT) in those patients is controversial. OBJECTIVE: To determine whether NRT in ICU patients affects the need for sedatives/analgesics, ventilator days, and ICU stay. METHODS: In a 20-bed ICU, 40 subjects were randomized to either a 21 mg nicotine patch or a placebo nicotine patch daily until either ICU discharge, transfer to a medical floor, or 10 weeks in the ICU. We collected data on sedatives/analgesics use during ICU stay and use and duration of mechanical ventilation . RESULTS: There were 27 male and 13 female subjects. The mean age was 57.4 y in the intervention group and 52.5 y in the control group. The mean Acute Physiology and Chronic Health Evaluation II score was 14.3 in the intervention group and 13.8 in the control group. The mean ICU stay was 4.5 d in the intervention group and 7 d in the control group. The mean number of days on ventilator was 1.9 in the intervention group and 3.5 in the control group. The number of days on sedation/analgesia was less in the intervention group than in the control group. CONCLUSIONS: Although ICU stay and ventilator days decreased numerically in this pilot study, statistically there was no beneficial effect from NRT. (International Standard Randomised Controlled Trial Register ISRCTN66928309)

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Section: Discussionmentioning

confidence: 99%

Outcome of Nicotine Replacement Therapy in Patients Admitted to ICU: A Randomized Controlled Double-Blind Prospective Pilot Study

Pathak

Rendon²,

Lupu³

et al. 2013

Respir Care

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“…They attributed the delirium to nicotine withdrawal because of its improvement following nicotine replacement therapy (NRT). Tran-Van and colleagues [8] reported a case with difficulty to wean from mechanical ventilation, and restlessness attributed to nicotine withdrawal. The patient's condition improved following NRT.…”

mentioning

confidence: 99%

“…However, the clinical impact of nicotine withdrawal in the critically ill has not been well described. Although there are case reports suggesting that prevention and treatment of nicotine withdrawal may be beneficial [7,8], retrospective studies have shown nicotine replacement therapy may increase mortality in the critically ill [10,11]. Future studies are warranted to describe the incidence and clinical manifestations of nicotine withdrawal.…”

mentioning

confidence: 99%

Critical care support of patients with nicotine addiction

Afessa

Keegan

2010

Critical Care

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Over 500 million of the current world population will die from diseases caused by smoking cigarettes. The symptoms and signs of nicotine withdrawal are not well described in the critically ill. Since the various conditions of critical illness may lead to clinical manifestations mimicking nicotine withdrawal, describing its specific manifestations may not be easy. A few case reports suggest that nicotine replacement therapy may ameliorate nicotine withdrawal in the critically ill. However, retrospective studies have found that it may increase mortality. Despite the abundance of active smokers, there is a paucity of data describing nicotine withdrawal, and its prevention and treatment options in the critically ill. Future studies are warranted to address these issues.

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Sevrage de la sédation en réanimation

Bruder¹,

Velly²

2010

Analgésie Et Sédation en Réanimation

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Agitation en réanimation : penser au syndrome de sevrage nicotinique

Cited by 9 publications

References 10 publications

Outcome of Nicotine Replacement Therapy in Patients Admitted to ICU: A Randomized Controlled Double-Blind Prospective Pilot Study

Outcome of Nicotine Replacement Therapy in Patients Admitted to ICU: A Randomized Controlled Double-Blind Prospective Pilot Study

Critical care support of patients with nicotine addiction

Sevrage de la sédation en réanimation

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