Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume

Raz, Naftali; Gunning-Dixon, Faith M.; Head, Denise; Rodrigue, Karen M.; Williamson, Adrienne; Acker, James D.

doi:10.1016/s0197-4580(03)00118-0

Cited by 626 publications

(592 citation statements)

References 69 publications

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“…This is similar to what has been reported in some previous studies (Lim et al, 1990, Convit et al, 1995, De Leon et al, 1997, Jernigan et al, 2001, Scahill et al, 2003, Raz et al, 2004a, Raz et al, 2004b, Du et al, 2006. However, after normalization the relationships were no longer significant.…”

Section: Volumetric Losssupporting

confidence: 91%

“…However, these findings in healthy subjects have been inconsistent. Some studies revealed that age was not significantly related to the volume reduction of the hippocampus (Sullivan et al, 1995, Sullivan et al, 2005; others obtained the opposite results (Lim et al, 1990, Convit et al, 1995, De Leon et al, 1997, Jernigan et al, 2001, Scahill et al, 2003, Raz et al, 2004a, Raz et al, 2004b, Du et al, 2006. The discrepancies in the results of these reports might be due to differences in the segmentation of anatomical regions, or in the age range of the subjects studied.…”

Section: Introductionmentioning

confidence: 94%

“…In addition to treating age as a matching factor, many studies have analyzed the effect of aging on the volume of the hippocampus (Lim et al, 1990, Convit et al, 1995, Sullivan et al, 1995, De Leon et al, 1997, Jernigan et al, 2001, Scahill et al, 2003, Raz et al, 2004a, Raz et al, 2004b, Sullivan et al, 2005, Du et al, 2006. However, these findings in healthy subjects have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

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Age effects on hippocampal structural changes in old men: The HAAS

Valentino

Scher

et al. 2008

NeuroImage

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Understanding the variability of the hippocampus in human brain research is essential. The effect of age on the hippocampus has been explored in several studies that have been focused on either normal aging or neural degeneration. Shape analysis of magnetic resonance imaging (MRI) provides morphological measures for brain structures. This study further investigates the age effects on hippocampal morphology in three groups (104 normal controls, 24 Alzheimer's disease (AD) and 14 vascular dementia (VaD) patients). By utilizing a parametric shape analysis of hippocampal MRI scans, each individual distance map is generated and analyzed statistically. Specifically, after eliminating similarity parameters (rotation, translation, and scaling) effects for each hippocampus, an individual distance map is generated from parametric hippocampal surfaces and medial axes. Then statistical methods, including regression, and permutation tests, are applied to detect the differences in hippocampal distance maps and volumes under the effect of age in each group. Statistical analyses reveal that the loss of hippocampal volume and changes in shape are more significantly related to aging in the control group than in AD/VaD. The results also show that the asymmetry of hippocampus in healthy subjects is greater than that in either of the disease groups. Our study shows that 3D statistical shape analysis could enhance the understanding of age effects on local areas of hippocampi. However, the sample sizes of disease groups are relatively low; further studies with more AD/VaD data are needed.

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Section: Volumetric Losssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Age effects on hippocampal structural changes in old men: The HAAS

Valentino

Scher

et al. 2008

NeuroImage

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“…However, when examining the sample split by gender, the negative association only remained for the women. Although the propensity of the literature supports similar age‐related hippocampal volume loss for men and women (Jack et al., 2015; Mu, Xie, Wen, Weng, & Shuyun, 1999; Raz et al., 2004, 2005), there are reports of both women‐ and men‐specific age–hippocampal volume relationships (Murphy et al.,1996; Pruessner et al., 2001). For the current sample, the lack of significant association in the men may be explained by this gender not experiencing a similar age‐related trajectory in hippocampal volume, and therefore not experiencing the benefits of CRF on hippocampal volume.…”

Section: Discussionmentioning

confidence: 99%

Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease

et al. 2017

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IntroductionCardiorespiratory fitness (CRF) has been shown to be related to brain health in older adults. In individuals at risk for developing Alzheimer's disease (AD), CRF may be a modifiable risk factor that could attenuate anticipated declines in brain volume and episodic memory. The objective of this study was to determine the association between CRF and both hippocampal volume and episodic memory in a cohort of cognitively healthy older adults with familial and/or genetic risk for Alzheimer's disease (AD).MethodsEighty‐six enrollees from the Wisconsin Registry for Alzheimer's Prevention participated in this study. Participants performed a graded maximal exercise test, underwent a T‐1 anatomical magnetic resonance imaging scan, and completed the Rey Auditory Verbal Learning Test (RAVLT).ResultsThere were no significant relationships between CRF and HV or RAVLT memory scores for the entire sample. When the sample was explored on the basis of gender, CRF was significantly associated with hippocampal volume for women. For men, significant positive associations were observed between CRF and RAVLT memory scores.SummaryThese results suggest that CRF may be protective against both hippocampal volume and episodic memory decline in older adults at risk for AD, but that the relationships may be gender specific.

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“…However, other reports, which can vary by technique, number of subjects, screening criterion, age range, or proportion of older participants, have described global decreases of WM volume with age in both sexes (Guttmann et al 1998;Courchesne et al 2000;Ge et al 2002;Allen et al 2005). Cross-sectional studies also show a loss of WM volume with age in specific regions of the brain, which occurs in both men and women (Raz et al 1997;Bartzokis et al 2001;Jernigan et al 2001;Raz et al 2004;Allen et al 2005;Walhovd et al 2005). A loss of WM volume, which is paralleled by GM loss, is even detectable across a two decade range in otherwise healthy elderly (Lemaitre et al 2005).…”

mentioning

confidence: 98%

Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline

Kohama

Rosene

Sherman

2011

AGE

107

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The cognitive decline associated with normal aging was long believed to be due primarily to decreased synaptic density and neuron loss. Recent studies in both humans and non-human primates have challenged this idea, pointing instead to disturbances in white matter (WM) including myelin damage. Here, we review both cross-sectional and longitudinal studies in humans and non-human primates that collectively support the hypothesis that WM disturbances increase with age starting at middle age in humans, that these disturbances contribute to age-related cognitive decline, and that age-related WM changes may occur as a result of free radical damage, degenerative changes in cells in the oligodendrocyte lineage, and changes in microenvironments within WM.

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Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume

Cited by 626 publications

References 69 publications

Age effects on hippocampal structural changes in old men: The HAAS

Age effects on hippocampal structural changes in old men: The HAAS

Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease

Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline

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