2016
DOI: 10.18632/aging.101128
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Abstract: A better understanding of the complex relationship between aging and cancer will provide important tools for the prevention and treatment of neoplasia. In these studies, the hypothesis was tested that aging may fuel carcinogenesis via alterations imposed in the tissue microenvironment. Preneoplastic hepatocytes isolated from liver nodules were orthotopically injected into either young or old syngeneic rats and their fate was followed over time using the dipeptidyl-peptidase type IV (DPPIV) system to track dono… Show more

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Cited by 17 publications
(31 citation statements)
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References 40 publications
(51 reference statements)
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“…109 As demonstrated by various studies performed in murine models, the expression of senescence markers in the liver create a microenvironment that promotes cancer development. 110,111 Indeed, age-related alterations support the selective growth of both preneoplastic cell populations and normal, homotypical transplanted cells. 112 This suggests that there are similar mechanisms behind the growth of both cell types, which could represent a therapeutic target in the treatment of neoplasms.…”
Section: Aging-related Molecular Alterations In Liver Diseasesmentioning
confidence: 99%
“…In this work, we investigated whether fecal microbiota variation is induced by short-term CR and whether such change persists in long-lasting CR, in a rat model of aging. 8 As for the majority of murine experimental models, animals were fed AL, a condition that might be assimilated to overfeeding, given the poor energy expenditure in the animal house settings, compared to wild rats in their natural environments. 9 To shed light on timing and nature of microbial composition changes, fecal microbiota was evaluated in young growing and adult Fisher 344 rats, comparing animals fed AL and animals fed with 70% of the AL ratio (CR).…”
Section: Introductionmentioning
confidence: 99%
“…This hypothesis was also grounded on our recent report describing the promoting capability of an aged tissue-microenvironment on the growth of pre-neoplastic hepatocytes [3]. Two groups of rats were fed either AL or a CR diet for 17 months, starting at 8 weeks of age and they were then transplanted with pre-neoplastic hepatocytes.…”
Section: Discussionmentioning
confidence: 91%
“…Hepatocyte nodules were induced according to a well characterized experimental model in the rat [3]. Briefly, two-month old male Fischer 344 DPPIV+ rats were injected with a single dose of diethylnitrosamine (DENA, 200 mg/kg.…”
Section: Methodsmentioning
confidence: 99%
“… 46 On the other hand, the same preneoplastic cells formed visible nodules in the majority of recipients (17/18) following infusion into the livers of aged (18- to 20-mo-old) syngeneic rats. 57 It should be mentioned that in both groups, cells were injected through the portal circulation and they were therefore seeded in the liver parenchyma mainly as single hepatocytes, with ample possibility to interact with the host tissue environment.…”
Section: The Tumor-promoting Effect Of the Aged Tissue Environmentmentioning
confidence: 99%