Aging of dogs and Drosophila as described based on the kinetic theory

Viktorov, A. A.; Gladkikh, V. D.; Morozova, E. E.

doi:10.1134/s2079057017030134

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Note that sensitivity of LS to stressor intensity is different. For example, chronic X-ray radiation exposition of dogs within range of dose rate changes from 0 to 54cGr /day results in change in parameter μ from 1.523 to 4.200, while the life expectancy of dogs decreases under effect of radiation from 192 months to 1 month [24][25][26][27]. For human, there is no such data.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2020

GGS

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The possibility of applying the kinetic theory of aging of biological species published earlier by the authors of this work to assess and predict changes in the number of specific populations is evaluated. The populations of the USA, China and Russia, as well as the population of mice observed in the experiment "Mouse paradise" of the American scientist John Calhoun are considered. To this end, a historically consistent analysis of the main previously proposed multi-scenario mathematical models describing demographic data and predicting the dynamics of the population was performed. The results of these models show a decrease in the population growth rate, a tendency toward a limit with an increase in historical time, the achievement of such a limit in some developed countries with a relatively high level of social security, a subsequent decrease in the number and further uncertainty of the final population outlook in the distant future. In addition, these models made it possible to establish that the observed population growth in developed countries is unambiguously accompanied by its aging-a relative predominant increase in the number of elderly people compared to the number of the younger generation (people are aging, the population of countries is aging).In this work, the assumption was made and confirmed that the dynamics of the aging of the population of the countries of the World corresponds to the dynamics of aging of a person of one generation and is mathematically described by the differential equation of the kinetic theory of aging of living systems of the same type with close values of the parameters. The biophysical meaning of the parameters of the kinetic equation reflects Selye's G [1] concept of the determining role of stress in human life and populations. An analysis of the changes in the numbers of the considered populations of humans and mice at various stages of their development is qualitatively commented on from the standpoint of comparative tension according to Selye G [1]. To assess the degree of aging of a biological object of one population in kinetic theory, the probability of death during life is selected as an indicator of aging. In this work, the probability of reaching the maximum population size was chosen as an indicator of the aging of a biological object of various populations. The published literature predicts various options for changing the population after reaching a maximum maintaining the reached maximum level and decreasing to a certain limit, less than the maximum achieved. In this paper, based on an analysis of its results and an analogy with the complete degeneration of mice in the "Mouse Paradise" experiment, a conclusion is drawn about a hypothetically possible third variant of the limiting decrease in the population-its complete degeneration.

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Section: Resultsmentioning

confidence: 99%

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2020

GGS

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Kinetic Model of Aging Biological Species in Natural Habitat

2019

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Analysis and Forecast Based on the Kinetic Equation for Changing the Numerical Composition of Living Systems

Victorov

Kholodnov

2020

JBBS

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The possibility of applying the kinetic theory of aging of biological species published earlier by the authors of this work to assess and predict changes in the number of specific populations is evaluated. The populations of the USA, China and Russia, as well as the population of mice observed in the experiment "mouse paradise" of the American scientist John Calhoun are considered. To this end, a historically consistent analysis of the main previously proposed multi-scenario mathematical models describing demographic data and predicting the dynamics of the population was performed. The results of these models show a decrease in the population growth rate, a tendency toward a limit with an increase in historical time, the achievement of such a limit in some developed countries with a relatively high level of social security, a subsequent decrease in the number and further uncertainty of the final population outlook in the distant future. In addition, these models made it possible to establish that the observed population growth in developed countries is unambiguously accompanied by its aging - a relative predominant increase in the number of elderly people compared to the number of the younger generation (people are aging, the population of countries is aging). In this work, the assumption was made and confirmed that the dynamics of the aging of the population of the countries of the World corresponds to the dynamics of aging of a person of one generation and is mathematically described by the differential equation of the kinetic theory of aging of living systems of the same type with close values of the parameters. The biophysical meaning of the parameters of the kinetic equation reflects G. Selye's concept of the determining role of stress in human life and populations. An analysis of the changes in the numbers of the considered populations of humans and mice at various stages of their development is qualitatively commented on from the standpoint of comparative tension according to G. Selye. To assess the degree of aging of a biological object of one population in kinetic theory, the probability of death during life is selected as an indicator of aging. In this work, the probability of reaching the maximum population size was chosen as an indicator of the aging of a biological object of various populations. The published literature predicts various options for changing the population after reaching a maximum - maintaining the reached maximum level and decreasing to a certain limit, less than the maximum achieved. In this paper, based on an analysis of its results and an analogy with the complete degeneration of mice in the “mouse paradise” experiment, a conclusion is drawn about a hypothetically possible third variant of the limiting decrease in the population - its complete degeneration.

show abstract

Aging of dogs and Drosophila as described based on the kinetic theory

Cited by 4 publications

References 6 publications

Untitled

Untitled

Kinetic Model of Aging Biological Species in Natural Habitat

Analysis and Forecast Based on the Kinetic Equation for Changing the Numerical Composition of Living Systems

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