Aging, not menopause, is associated with higher prevalence of hyperuricemia among older women

Krishnan, Eswar; Bennett, Mihoko V.; Chen, Linjun

doi:10.1097/gme.0000000000000230

Cited by 21 publications

(17 citation statements)

References 17 publications

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“…Contrarily, in women SUA levels remained fairly stable until the age of about 50, but continued to increase steeply thereafter. Similar findings were reported in a Western population-based study from Ireland 12 , in two considerably smaller Asian studies from China 20 and Taiwan 21 , and exclusively for women in the US 22,23 .…”

Section: Discussionsupporting

confidence: 85%

Sex- and age-specific variations, temporal trends and metabolic determinants of serum uric acid concentrations in a large population-based Austrian cohort

Zitt

Fischer

Lhotta

et al. 2020

Sci Rep

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Little is known about sex-and age-specific variations and temporal trends in serum uric acid (SUA) concentrations, the prevalence of hyperuricemia and its association with metabolic risk factors in the general population. Between January 1, 1985 and June 30, 2005 146,873 participants (42% women) were recruited. Prevalence of hyperuricemia was estimated applying a common (SUA > 360 µmol/L) and sex-specific cutoff points (women > 340 µmol/L, men > 420 µmol/L). At baseline, mean age was 41.2 years in men and 51.5 years in women, mean SUA concentration was 314.8 µmol/L and 243.6 µmol/L, respectively. Applying a common cutoff point, the prevalence of hyperuricemia was 18.5% in men and 4.4% in women and by sex-specific cutoff points it was 15.1% and 13.8%, respectively. SUA levels increased by 6.7 µmol/L per decade in men, but remained constant in women until the age of 50 years with a sharp increase by approximately 22 µmol/L per decade thereafter. In men and women, hyperuricemia was associated with obesity, hypertriglyceridemia and elevated gamma-glutamyl transferase. With increasing age SUA levels and the prevalence of hyperuricemia rise in a sex-specific manner. Above the age of 65 years, the sex-specific prevalence of hyperuricemia in women outreaches that in men.

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Section: Discussionsupporting

confidence: 85%

Sex- and age-specific variations, temporal trends and metabolic determinants of serum uric acid concentrations in a large population-based Austrian cohort

Zitt

Fischer

Lhotta

et al. 2020

Sci Rep

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“…In our study we observed a 9.1% overall prevalence of hyperuricemia in Xinjiang which is higher than that in US general population (3.2%) during the period of 2007-2008 [20] and that in other region of Chinese adults (8.4%) during the period of 2009-2010 [23]. This may be attributed to aging [41], increased prevalence of overweight and obesity [17,23], lifestyle changes, especially higher energy intake [42], increased consumption of foods rich in purines [43], diet soft drink [44], consumption of alcohol [24,45] and physical inactivity [46].…”

Section: Discussioncontrasting

confidence: 60%

Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008–2012)

Liu

Song

et al. 2020

Lipids Health Dis

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Background: Hyperuricemia predisposes to gout, which may result in tophi, kidney stones, or urate nephropathy even kidney failure. Many metabolic risk factors and disorders has been recognized as a key risk factor contributing to development of hyperuricemia. Aim: To determine the prevalence of hyperuricemia and its association with adiposity and dyslipidemia. Methods: We recruited non-hospitalized participants (aged ≥35 years) in Xinjiang, a northwest part of China based on the Cardiovascular Risk Survey (CRS 2008(CRS -2012. Information of general health status, seafood or internal organs intake and history of disease were obtained by using an interview-based questionnaire. The levels of serum uric acid (sUA) and creatinine and lipid profiles were measured. A multivariate logistic regression model was performed to assess the association between prevalence of hyperuricemia and adiposity and dyslipidemia. (Continued on next page)Results: This study recruited 16,611 participants, and 14,618 was included (mean age of 50.5 ± 12.6 years, 46.6% was males). The study population comprised three ethnic groups with 39.4% of Han, 32.6% of Uygur and 28% of Kazakh Chinese. The overall prevalence of hyperuricemia was 9.1% (95% CI: 8.6 to 9.6) and it was11.8% in men was 6.7% in women. The three ethnic groups also had different hyperuricemia prevalence with 15.4% in Han, 4.6% in Uygur and 5.5% in Kazakh Chinese, which corresponding to a respective mean sUA levels of 306.2 ± 86.9, 249.4 ± 76.1 and 259.8 ± 78.7 μmol/L. Participants with diabetes, hypertension or hypertriglyceridemia and higher blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC) had higher levels of sUA (P < 0.001 respectively). Multivariate logistic regression analysis revealed that age, gender, ethnicity, drinking, obesity, waist circumference, TG (≥2.26 mmol/L), TC (≥6.22 mmol/L) are major risk factors for hyperuricemia. Compared to the 35-44-year age group [adjusted odds ratio (AOR) = 1], the risk of hyperuricemia increased 1.61-fold in the 65-74-year age group (AOR = 1.61, 95% CI: 1.34-1.91; P < 0.001), and 1.71-fold in the 75-and older age group (AOR = 1.71, 95% CI: 1.27-2.29; P < 0.001). There was a 1.45-fold higher risk of hyperuricemia in men (AOR = 1.45, 95% CI: 1.24-1.68; P < 0.001) compared to women. Further, the risk of hyperuricemia increased significantly with drinking (AOR = 1.36; 95% CI: 1.16-1.61; P < 0.001), overweight (AOR = 1.25; 95% CI: 1.06-1.48; P = 0.01), obesity (AOR = 1.28; 95% CI: 1.10-1.49; P < 0.001), waist circumference (AOR = 1.48; 95% CI: 1.24-1.78; P < 0.001), TC (≥6.22 mmol/L, AOR = 1.45; 95% CI: 1.19-1.75; P < 0.001), TG (≥2.26 mmol/L, AOR = 2.74; 95% CI: 2.39-3.14; P < 0.001). Conclusions: These findings documented that the hyperuricemia is prevalent in the economically developing regions of northwest China. Hyperuricemia is associated with advanced age, male ender and general metabolic and cardiovascular risk factors. Obesity and dyslip...

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“…The rate of hyperuricemia increased and the mean eGFR decreased with increased age in both men and women, especially in older women. These gender difference was observed in other studies as well and was suggested to relate to natural aging, the decline in female hormone levels in older women and the reduced excretion of uric acid from the kidney (Chang et al, 2010;Krishnan, Bennett, & Chen, 2014;Liu et al, 2014;Lu et al, 2014;Yoshitomi et al, 2014).…”

Section: Normo-albuminuriamentioning

confidence: 71%

Gender differences in the association between hyperuricemia and diabetic kidney disease in community elderly patients

Guo

Niu

et al. 2015

Journal of Diabetes and its Complications

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Aging, not menopause, is associated with higher prevalence of hyperuricemia among older women

Abstract: Age is a better statistical explanation for the higher prevalence of hyperuricemia among older women than menopause status.

Cited by 21 publications

References 17 publications

Sex- and age-specific variations, temporal trends and metabolic determinants of serum uric acid concentrations in a large population-based Austrian cohort

Sex- and age-specific variations, temporal trends and metabolic determinants of serum uric acid concentrations in a large population-based Austrian cohort

Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008–2012)

Gender differences in the association between hyperuricemia and diabetic kidney disease in community elderly patients

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