Aging males’ symptoms in relation to the genetically determined androgen receptor CAG polymorphism, sex hormone levels and sample membership

Schneider, Gudrun; Nienhaus, Kathrin; Gromoll, Jörg; Heuft, Gereon; Nieschlag, Eberhard; Zitzmann, Michael

doi:10.1016/j.psyneuen.2009.09.008

Cited by 32 publications

(39 citation statements)

References 32 publications

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“…It can severely impact the life quality of old and middle-aged males, while it also has a negative effect on the functions of many organs and systems. 4 The general consensus is that the partial deficiency in levels of testosterone from gonads leads to the onset of LOH, but the exact pathogenesis and mechanism remain unclear. The diagnosis of LOH is primarily performed through the combination of symptom evaluation and the measurement of serum testosterone.…”

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confidence: 99%

Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities

Sun¹,

Liang²,

Chen³

et al. 2011

Asian J Androl

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This study sought to investigate late-onset hypogonadism (LOH) in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases of males aged 40-70 years were investigated. The aging male symptoms (AMS) scale and androgen deficiency in aging males (ADAM) questionnaire were used at the beginning of the investigation, followed by measurement of the sex hormone-related factors (total testosterone (TT), free testosterone (fT), sex hormone-binding globulin (SHBG) and bioavailability of testosterone (Bio-T)). There were 977 valid questionnaires. The LOH-positive rates shown by AMS and ADAM were 59.88% and 84.65%, respectively; values increased with the age of the patients. There were 946 results related to sex hormone measurements, which showed the following results: TT was not related to aging (P.0.05); levels of SHBG increased with age; and fT and Bio-T decreased with age. There was a significant difference in fT between LOH-positive and LOH-negative patients, as shown by the ADAM. In summary, TT levels were not related to aging, even though SHBG did increase while fT and Bio-T decreased with aging. Clinically, the diagnosis of LOH cannot be based on serum TT level. Keywords: ADAM; AMS; late-onset of hypogonadism; male aging; old and middle-aged males; survey INTRODUCTIONTestosterone deficiency in elderly males has become a rather interesting and controversial topic. Late-onset hypogonadism (LOH) is a common condition for old and middle-aged males around the world, and it is an acquired state of reduced function in gonads during later life stages. 1-3 The condition is affected by many factors. It can severely impact the life quality of old and middle-aged males, while it also has a negative effect on the functions of many organs and systems. 4 The general consensus is that the partial deficiency in levels of testosterone from gonads leads to the onset of LOH, but the exact pathogenesis and mechanism remain unclear. The diagnosis of LOH is primarily performed through the combination of symptom evaluation and the measurement of serum testosterone. Currently, the aging male symptoms (AMS) scale and the androgen deficiency in aging males (ADAM) questionnaire, because of the high sensitivity, ease of operation and time-saving characteristics, have become well recognized and widely used. The Chinese versions of the two charts have been in use for several years, but there are still no research data on the LOH-positive rates for both charts. Furthermore, epidemiological data on LOH from large community populations are even rarer. In order to understand the prevalence of LOH in old and middle-aged males in Shanghai communities, we initiated a large-sample survey on a community population aged 40-70 years in Shanghai between

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confidence: 99%

Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities

Sun¹,

Liang²,

Chen³

et al. 2011

Asian J Androl

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“…One study found a significant association of longer (CAG)n with higher total AMS scores in outpatients with sexual and aging male symptoms and patients with psychosomatic or psychiatric disorders but not in healthy control men older than 50 years. 31 CAG and GGN polymorphisms were supposed to have a role in AGA, but a meta-analysis exploring the association of (CAG)n and (GGN)n with AGA reported no significant findings.…”

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confidence: 99%

Androgen receptor (AR) gene (CAG)n and (GGN)n length polymorphisms and symptoms in young males with long-lasting adverse effects after finasteride use against androgenic alopecia

Chiriacò¹,

Cauci²,

Cecchin³

et al. 2017

European Urology Supplements

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“…One of the first attempts to investigate this problem was a study on genetically determined CAG polymorphism of the androgen receptor gene and AMS. The authors of the report found certain correlations between CAG number and the AMS global score, the psychological and somatic subscale, but not the sexual subscale [19]. We assessed male aging symptoms in the context of genetic variants of receptors for three neuropeptides - DA, 5-HT and MC.…”

Section: Discussionmentioning

confidence: 99%

Polymorphic Variants of Neurotransmitter Receptor Genes May Affect Sexual Function in Aging Males: Data from the HALS Study

Jóźków¹,

Słowińska-Lisowska²,

Łaczmański

et al. 2013

Neuroendocrinology

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Background/Aims: Human behavior is influenced by a number of brain neurotransmitters. Central dopamine, serotonin and melanocortin systems have special importance for male sexual function. We searched for associations between male aging symptoms and polymorphic sites of serotonin (5-HTR_1B), melanocortin (MC4R) and dopamine (DRD2, DRD4) receptors. Methods: In a population-based sample, genotyping of 5-HTR1B (polymorphism: G861C), MC4R (polymorphisms: C-2745T, Val103Ile), DRD2 (polymorphism: C313T) and DRD4 (polymorphism: 48-bp VNTR) was performed in 387 healthy men. The Aging Males' Symptoms (AMS) scale was used to evaluate specific ailments of aging men. We analyzed answers to questions from the AMS scale. Five points of the questionnaire addressed sexual symptoms of the aging male: feeling of passing one's peak, decrease in beard growth, decrease in ability/frequency to perform sexually, decrease in the number of morning erections, and decrease in sexual desire/libido (lacking pleasure in sex, lacking desire for sexual intercourse). Relations between reported symptoms and variants of the polymorphic sites of the studied genes were assessed. Results: After adjusting for confounding factors (education, arterial hypertension, physical activity, weight, waist circumference) an association between the sexual dimension of AMS and genetic variants of 5-HTR1B G861C (p = 0.04) was observed. Conclusions: Variability of neurotransmitter receptor genes may be associated with sexual symptoms of aging in men.

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Aging males’ symptoms in relation to the genetically determined androgen receptor CAG polymorphism, sex hormone levels and sample membership

Cited by 32 publications

References 32 publications

Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities

Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities

Androgen receptor (AR) gene (CAG)n and (GGN)n length polymorphisms and symptoms in young males with long-lasting adverse effects after finasteride use against androgenic alopecia

Polymorphic Variants of Neurotransmitter Receptor Genes May Affect Sexual Function in Aging Males: Data from the HALS Study

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