Aging Induces Changes in the Somatic Nerve and Postsynaptic Component without Any Alterations in Skeletal Muscles Morphology and Capacity to Carry Load of Wistar Rats

Neto, Walter Krause; Silva, Wellington de Assis; Ciena, Adriano Polican; Souza, Romeu Rodrigues de; Anaruma, Carlos Alberto; Gama, Eliane Florêncio

doi:10.3389/fnins.2017.00688

Cited by 4 publications

(1 citation statement)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since SFI is very sensitive to lesion in this nerve (16), the decreased SFI found in 24- and 30-month-old rats in the present study indicates sciatic nerve lesion. In fact, morphological changes were found in peripheral nerves of 10- and 24-month-old Wistar rats (31).…”

Section: Discussionmentioning

confidence: 99%

Age-related changes and effects of regular low-intensity exercise on gait, balance, and oxidative biomarkers in the spinal cord of Wistar rats

Silveira

Kroth

Santos

et al. 2019

Braz J Med Biol Res

View full text Add to dashboard Cite

The present study aimed to analyze age-related changes to motor coordination, balance, spinal cord oxidative biomarkers in 3-, 6-, 18-, 24-, and 30-month-old rats. The effects of low-intensity exercise on these parameters were also analyzed in 6-, 18-, and 24-month-old rats. Body weight, blood glucose, total cholesterol, and high-density lipoprotein (HDL) cholesterol were assessed for all rats. The soleus muscle weight/body weight ratio was used to estimate skeletal muscle mass loss. Body weight increased until 24 months; only 30-month-old rats exhibited decreased blood glucose and increased total cholesterol and HDL cholesterol. The soleus muscle weight/body weight ratio increased until 18 months, followed by a small decrease in old rats. Exercise did not change any of these parameters. Stride length and step length increased from adult to middle age, but decreased at old age. Stride width increased while the sciatic functional index decreased in old rats. Performance in the balance beam test declined with age. While gait did not change, balance improved after exercise. Aging increased superoxide anion generation, hydrogen peroxide levels, total antioxidant capacity, and superoxide dismutase activity while total thiol decreased and lipid hydroperoxides did not change. Exercise did not significantly change this scenario. Thus, aging increased oxidative stress in the spinal cord, which may be associated with age-induced changes in gait and balance. Regular low-intensity exercise is a good alternative for improving age-induced changes in balance, while beneficial effects on gait and spinal cord oxidative biomarkers cannot be ruled out because of the small number of rats investigated (n=5 or 6/group).

show abstract

Section: Discussionmentioning

confidence: 99%

Age-related changes and effects of regular low-intensity exercise on gait, balance, and oxidative biomarkers in the spinal cord of Wistar rats

Silveira

Kroth

Santos

et al. 2019

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

Remodeling of the skeletal muscle and postsynaptic component after short-term joint immobilization and aquatic training

Rocha

Jacob

Barbosa

et al. 2020

Histochem Cell Biol

View full text Add to dashboard Cite

Different patterns in age‐related morphometric alteration of myelinated fibers and capillaries of the tibial nerve: a longitudinal study in normal rats

et al. 2020

View full text Add to dashboard Cite

Age‐related regression of myelinated fibers in peripheral nerves of the lower limbs is strongly influenced by capillaries and results in balance dysfunction and falls. However, the temporal relationships between alteration patterns of myelinated fibers and capillaries have not yet been clarified. This study aimed to investigate age‐related morphological and histological changes of both myelinated fibers and capillaries in peripheral nerves to clarify whether myelinated fibers or capillaries change earlier. Seven male Wistar rats each were randomly selected at 20 weeks (young group), 70 weeks (middle group), and 97 weeks (old group) for histological evaluations. The left and right tibial nerves were removed morphologically and histologically to examine myelinated fibers and capillaries. Axon diameter and myelin thickness were almost unaltered in the middle group compared with the young group but were significantly reduced in the old group when compared with the other two groups. However, the capillary diameter and number of microvascular branch points were substantially reduced in the middle group. The current study demonstrates that myelinated fibers of peripheral nerves show signs of regression in elderly rats, whereas capillaries start to reduce in middle‐aged animals. In normal aging of the tibial nerve, capillaries may regress before myelinated fibers.

show abstract

Aging Induces Changes in the Somatic Nerve and Postsynaptic Component without Any Alterations in Skeletal Muscles Morphology and Capacity to Carry Load of Wistar Rats

Cited by 4 publications

References 80 publications

Age-related changes and effects of regular low-intensity exercise on gait, balance, and oxidative biomarkers in the spinal cord of Wistar rats

Age-related changes and effects of regular low-intensity exercise on gait, balance, and oxidative biomarkers in the spinal cord of Wistar rats

Remodeling of the skeletal muscle and postsynaptic component after short-term joint immobilization and aquatic training

Different patterns in age‐related morphometric alteration of myelinated fibers and capillaries of the tibial nerve: a longitudinal study in normal rats

Contact Info

Product

Resources

About