1970
DOI: 10.1093/geronj/25.3.184
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Aging Changes in Ultrastructure and Enzymatic Activity of Articular Cartilage of Guinea Pigs

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1971
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Cited by 34 publications
(9 citation statements)
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“…Old guinea pigs displayed enhanced activity of the enzymes concerned in energy metabolism when the biochemically determined activities were calcu lated on the basis of DNA levels (56). This observation is not at variance with our results, since it was probably related to the cell proliferation described in the same study.…”
Section: Discussionsupporting
confidence: 77%
“…Old guinea pigs displayed enhanced activity of the enzymes concerned in energy metabolism when the biochemically determined activities were calcu lated on the basis of DNA levels (56). This observation is not at variance with our results, since it was probably related to the cell proliferation described in the same study.…”
Section: Discussionsupporting
confidence: 77%
“…It is possible that in the mice used for the present experiments, functional stimulation may have been more marked than is suggested by the structural findings. However, there may be another reason for the comparatively low level response of these chondrocytes: the age of the mice used corresponds to middle rather than to old age; during this period of life, certain enzyme activities in articular cartilage of guinea pigs were lower than at all other ages [10], and this suggests that synthesis of structural cell products may also be at a minimum at this age. The deposition of increased amounts of glycogen in chondrocytes, which was not observed in young adult mice treated with the extract may be related to the absence of other synthetic activities.…”
Section: Discussionmentioning
confidence: 99%
“…Solid lines represent the values obtained for the shoulder joints and shown in detail in Tables 3 and 5; broken lines represent the corresponding figures for the joints of the lower extremities, published previously in detail (Silberberg et al, 1970;Silberberg & Lesker, 1971;Silberberg, Lesker, & Hasler, in press). The four curves for each enzyme in males or females and upper or lower extremity respectively are drawn on the same scale; the scales for different enzymes are not always identical, since activities are variously expressed in moles, millomoles, micromoles, or grams.…”
Section: Histochemistrymentioning
confidence: 90%
“…(Silberberg et al, 1970, Silberberg & Lesker, 1971. Owing to the scarcity of animals in the oldest age group and to the small amount of cartilage available in old animals, not all enzymes could be examined in each animal.…”
Section: Methodsmentioning
confidence: 99%