Aging behavior of pharmaceutical formulations of itraconazole on SBA-15 ordered mesoporous silica carrier material

Amorphous Solid Dispersions

“…When drug-loaded MPS comes in contact with aqueous dissolution media, drug release is facilitated. This concept is supported by the observations of the Mellaerts et al (2010) who studied the effect of itraconazole release from SBA-15 OMS stored at 0, 52, and 97 % humidity. The highest release was observed in the sample stored at 97 % humidity .…”

Sulfonic acid-functionalized mesoporous silicas: Microcalorimetric characterization and catalytic performance toward biodiesel synthesis

“…These features confer them a high potential for possible applications in different fields, such as: (bio) catalysis [2][3][4], (bio) adsorption [3,5], controlled release of therapeutic agents [6][7][8][9][10] and nano-medicine [11,12]. All these applications take advantage by the possibility to chemically modify the surface of OMMs by introducing suitable chemical groups [1].…”

Evaluation of ordered mesoporous silica as a carrier for poorly soluble drugs: Influence of pressure on the structure and drug release

“…Textural and structural properties of OMS have also been assessed based on their drug loading and release behavior. [19][20][21][22] However, there is a significant lack in our understanding of how the pressure used to make solid dosage forms such as tablets affects the performance of these materials. Ghedini et al 23 evaluated the response of MCM-41, SBA-15, and silica gel to pressure, but only one applied pressure value was used and their assessment was limited to a slowrelease formulation.…”