Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome

Inflammageing assessed by MMP9 in normal Japanese individuals and the patients with Werner syndrome

“…However, the level of serum MMP9 in Japanese population was several times lower than that in the western populations, the situation being similar as of hsCRP as already reported (5). The sharp contrast of serum hsCRP and MMP9 levels between Japanese and the western populations is not still clear, but has been presumed by the difference in diet, lifestyle and body mass index (3,7).…”

“…Most Japanese studies on the chronological changes of inflammatory conditions in normal ageing indicated a similar age-associated increase of low grade inflammation to the western studies, though the level of inflammation assessed by hsCRP was several times lower than that in the western populations (3,5).…”

“…The serum level of MMP9 significantly increased 1.008 (= exp (0.008)) times a year, as shown in the coefficient of Age in the right table of Figure 1. Neither significant gender difference of serum level of MMP9 was observed concerning to the age-associated increase in MMP9 level as indicated in the right table of Figure 1, nor concerning to the mean ± SE level of MMP9 (ng/mL) throughout all ages between male (127.6 ± 12.7; n = 91, solid line for regression model) and female (143.8 ± 10.1; n = 126, dotted line for regression model), as of the result of hsCRP (5).…”

“…A total of 217 normal serum samples (M = 91, F = 126) between 1 to 100 years old were the same sera as were studied in the previous study (5). The normal individuals, enjoying the usual daily life at home or nursing home, had neither apparent inflammatory diseases including infection, cancer, lymphoproliferative disorders, DM, Alzheimer disease, autoimmune diseases and arthritis at the time of serum sampling, nor history of cardio-/cerebro-vascular accidents.…”

Decreased serum level of HMGB1 and MyD88 during human aging progress in healthy individuals

“…In this study, we also detected the serum level of CRP as a routinely monitored inflammation marker in the whole healthy people. Goto et al reported that the serum highly sensitive CRP level increased significantly with normal aging from both sexes [33]. Similarly, we found that CRP was positively correlated with age.…”