Aging as a complex of typical pathophysiological processes

Background: Positioned as one of the central members in cellular antioxidant defense, glutathione reductase (GSR) determines the oxidative status of a cell. The level of its activity changes in certain physiological and pathological conditions. The rs1002149 polymorphic loci of the GSR gene, associated with the level of enzyme activity, is a potential molecular-genetic marker of complexly inherited traits (aging, multifactorial diseases). Since the glutathione system is responsible for the interaction with environmental factors, it is important to take into account the specifics of these system components actions, in particular GSR, in populations living in environments with different technogenic load. The aim of the study: The purpose of the study was the population-genetic analysis of the allelic state by the polymorphic Оригинальная статья Original article

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Section: аннотацияunclassified

Population analysis of the polymorphic marker rs1002149 of the glutathione reductase gene in residents of the Republic of Bashkortostan and Abkhazia

Erdman¹,

Данилко²,

Матуа³

et al. 2019

RR in B

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Concept of Reference Diagnostics as the Foundation for Developing Diagnostic Algorithm to Support Doctor’s Decision-Making

Yakushin,

Vorobeva,

Vasiliev

et al. 2023

City Healthcare

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The article analyzes current conceptual approaches to developing algorithms for supporting doctor's de-cision-making process. The need for application of sorting algorithms to generate decision-supporting algo-rithms is explained. We suggest a concept of reference diagnostics based on systematization of topical and nosological series that determine the direction and sequence of diagnostic process. According to the concept, each possible pathological region localization and each disease are presented as a set of positive and negative reference signs. In order to demonstrate the sequence of diagnostic algorithm elaboration, a specific neuro-logical pathology is used as an example. The prospects for the practical application of reference diagnostics in clinical medicine are defined.

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Aging as a complex of typical pathophysiological processes

Abstract: aging as a comPleX of TYPical PaThoPhYsiological Processes solovev i. a. 1, 2 , shaposhnikov m. V. 1 , melerzanov a. V. 3 , moskalev a. a. 1, 2, 3, 4

Cited by 2 publications

References 18 publications

Population analysis of the polymorphic marker rs1002149 of the glutathione reductase gene in residents of the Republic of Bashkortostan and Abkhazia

Population analysis of the polymorphic marker rs1002149 of the glutathione reductase gene in residents of the Republic of Bashkortostan and Abkhazia

Concept of Reference Diagnostics as the Foundation for Developing Diagnostic Algorithm to Support Doctor’s Decision-Making

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