Aging and oxidative stress

Junqueira, Virgínia Berlanga Campos; Barros, S. B. M.; Chan, Sandra S.; Rodrigues, Luciano; Giavarotti, Leandro; Abud, Ronaldo L.; Deucher, Guilherme Paulo

doi:10.1016/j.mam.2004.02.003

Cited by 253 publications

(162 citation statements)

References 47 publications

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“…Plasma TBAR's were significantly higher in middle-aged group than in the older group, with the highest values in females. We also found a negative linear regression between age and TBARS levels (r ¼ À0.20; P ¼ 0.01), whereas others have reported a positive correlation between age and TBARS levels (Junqueira et al, 2004). In agreement with the present findings, some studies did not report a modified production of lipoperoxides with advancing age (Hininger et al, 1997;Savarino et al, 2001).…”

Section: Discussionsupporting

confidence: 91%

“…For example, depending on the study, subjects are considered as older at 60 y, 70-80 y, or 480 y and lifestyles (free living older, disabled, institutionalised, hospitalised) are also very different. The data from literature suggest that lipid peroxidation is a less sensitive marker of oxidative stress than protein oxidation (Kasapoglu and Ö zben, 2001;Junqueira et al, 2004). In this study, this hypothesis is supported by the fact that the correlation coefficients were higher for protein oxidation than for TBARS.…”

Section: Discussionsupporting

confidence: 75%

“…In several experimental models of aged animals, the activity of antioxidant enzymes are unaltered, which may rule out a lack of protection due to a decrease in the activity of these enzymes (Remacle et al, 1992). However, in humans, some studies reported a decreased SOD activity whereas others described an enhanced activity (Andersen et al, 1997;Mecocci et al, 2000;Junqueira et al, 2004) in ageing, as an adaptive response to an age-related oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Several theories have been proposed to explain the ageing process, but there is increasing evidence that ageing might be caused by the deleterious and cumulative effects of reactive oxygen species (ROS) generated throughout the lifespan (Harman, 1956;Knight, 2000;De La Fuente, 2002;Junqueira et al, 2004). Oxidative stress has been reported to increase in elderly subjects, possibly arising from an uncontrolled production of free radicals by ageing mitochondria and decreased antioxidant defences.…”

Section: Introductionmentioning

confidence: 99%

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Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

et al. 2005

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Objective: Oxidative stress has been reported to increase with ageing. However, the data in healthy humans remain controversial and studies in free-living elderly people are scarce. The objective of the present study was to compare age-related oxidative stress in late middle-aged and older free-living subjects. Design: The effect of ageing on oxidative stress and antioxidant parameters was investigated in 188 middle-aged subjects from Clermont-Ferrand (France) and Coleraine (UK), and in 199 older subjects from Grenoble (France) and Roma (Italy). Plasma thiol (SH) groups, define definition (TBAR's) and total glutathione (GSH), define definition (FRAP), and superoxide dismutase (SOD) activity were measured at baseline of the ZENITH study. Results: Plasma SH groups and FRAP and, surprisingly, TBAR's were significantly lower in free-living older subjects compared to younger subjects (Po0.001, Po0.001, Po0.01, respectively), but there was no significant differences in GSH levels. Conclusion: European free-living healthy older do not appear to be exposed to an acute oxidative stress. However, the highly significant positive correlation between plasma SH group oxidation or decreased FRAP and ageing is predictive of an increased risk of oxidative stress in older subjects. Moreover, the comparison between middle-aged and older subjects regarding oxidative stress parameters suggests also a progressive and slow decline of antioxidant status in healthy free-living older elderly and underline the impact on life-style factors on successful ageing.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

et al. 2005

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“…Among these, the free radical theory points towards oxidative stress as the main determinant in the deleterious and cumulative effects in the biology of aging and in many age-associated degenerative diseases (Sohal and Orr 2012;Junqueira et al 2004;Harman 1956). Additionally, increased oxidative stress has been reported in elderly subjects, involving processes such as an age-related increase in mitochondrial reactive oxygen species (ROS) production and a progressive decline in the reduced glutathione (GSH):oxidized glutathione (GSSG) ratio and redox potential (Sohal et al 1987;Rebrin and Sohal 2008).…”

Section: Introductionmentioning

confidence: 99%

Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people

Meza-Miranda

Camargo

Rangel‐Zúñiga

et al. 2013

AGE

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We have investigated whether dietary fat modifies the postprandial oxidative stress in adipose tissue of elderly people. Twenty participants received three diets for 4 weeks each: SFA-rich diet, Mediterranean (Med) diet enriched in MUFA with virgin olive oil, and a low-fat, high-carbohydrate diet enriched in n-3 PUFA (α-linolenic acid from plant origin) (CHO-PUFA diet). After 12 h of fasting, volunteers received a breakfast reflecting the fatty acid composition of the diet ingested in the preceding dietary period. Med diet induced higher postprandial SOD2 and TrxR mRNA levels, and CHO-PUFA diet induced higher GPx1 and TrxR mRNA levels compared with SFA-rich diet. Med and CHO-PUFA breakfasts induced a postprandial increase in plasma reduced glutathione (GSH), and a greater postprandial GSH/oxidized glutathione ratio compared to the SFArich diet. Our study suggests that the consumption of Med and CHO-PUFA diets may reduce postprandial oxidative stress compared to an SFA-rich diet, which may be due to higher antioxidant enzymes gene expression in adipose tissue.

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Basal neutrophil function in human aging: Implications in endothelial cell adhesion

Nogueira‐Neto

Cardoso

Monteiro

et al. 2016

Cell Biology International

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Much attention has been drawn to the pro-inflammatory condition that accompanies aging. This study compared parameters from non-stimulated neutrophils, obtained from young (18-30 years old [y.o.]) and elderly (65-80 y.o.) human volunteers. Measured as an inflammatory marker, plasmatic concentration of hs-CRP was found higher in elderly individuals. Non-stimulated neutrophil production of ROS and NO was, respectively, 38 and 29% higher for the aged group. From the adhesion molecules evaluated, only CD11b expression was elevated in neutrophils from the aged group, whereas no differences were found for CD11a, CD18, or CD62. A 69% higher non-stimulated in vitro neutrophil/endothelial cell adhesion was observed for neutrophils isolated from elderly donors. Our results suggest that with aging, neutrophils may be constitutively producing more reactive species in closer proximity to endothelial cells of vessel walls, which may both contribute to vascular damage and reflect a neutrophil intracellular disrupted redox balance, altering neutrophil function in aging.

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Aging and oxidative stress

Cited by 253 publications

References 47 publications

Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people

Basal neutrophil function in human aging: Implications in endothelial cell adhesion

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