Aging Affects the Retrobulbar Circulation Differently in Women and Men

Harris, Alon; Harris, Mira; Biller, José; Garzozi, Hanna J.; Zarfty, Drora; Ciulla, Thomas A.; Martin, Bruce

doi:10.1001/archopht.118.8.1076

Cited by 107 publications

(94 citation statements)

References 27 publications

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“…It is possible that the differences between the two study groups in age, IOP, and visual field damage may justify the differences in blood flow parameters between POAG and PXE patients. However, Harris et al, 28 using CDI, found that in healthy subjects the ophthalmic arterial EDV decreased and RI rose with 29 found that in normal subjects the flow velocities of all considered vessels progressively decline whereas RI values increase with advancing age. Glaucomatous eyes with uncontrolled IOP and with visual field worsening showed a statistically significant decrease in the EDV flow velocities and an increase in the resistivity index value in ciliary arteries.…”

Section: Discussionmentioning

confidence: 98%

Ocular haemodynamics in pseudoexfoliative and primary open-angle glaucoma

Martínez

Sánchez

2006

Eye

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Objective To compare the retrobulbar haemodynamic parameters in the ophthalmic artery (OA) and short posterior ciliary arteries (SPCA) in pseudoexfoliative and primary open-angle glaucoma patients. Subjects and methods fourty-three eyes from 43 patients with pseudoexfoliative glaucoma (PXE) and 31 eyes from 31 patients with primary open-angle glaucoma (POAG) who met the inclusion/exclusion criteria were included in this prospective cross-sectional study. Colour Doppler imaging measurements, peak systolic velocity (PSV), and end-diastolic velocity (EDV) were assessed in the OA and posterior ciliary arteries (PCA). Pourcelot resistivity indices (RI) were calculated. Visual function was assessed using the 24-2 Swedish Interactive Threshold Algorithm (SITA). The main outcomes of the study were PSV, EDV, and RI in the OA and SPCA. Results In POAG patients, PSV and EDV were significantly lower in the OA, P ¼ 0.003 and Po0.001 respectively, and in the PCA, P ¼ 0.003 and Po0.001 respectively, when compared with the PXE group. The RI was significantly higher, Po0.001, in both vessels, in the POAG group. Conclusion The results of this study have found reduced PSV and EDV and increased RI in the retrobulbar vessels of POAG patients when compared with PXE patients.

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Section: Discussionmentioning

confidence: 98%

Ocular haemodynamics in pseudoexfoliative and primary open-angle glaucoma

Martínez

Sánchez

2006

Eye

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“…The changes in retrobulbar arteries during menopause are not clear. Harris et al [35]compared postmenopausal women who had never received HRT with similarly aged men and found the women to have decreased EDV and increased RIs of the NSPCA and TSPCA. The same authors also found a decrease in EDV and an increase in the RI of the OA, a decrease in the blood flow velocity of the NSPCA and TSPCA in postmenopausal women compared with young menstruating women [34].…”

Section: Discussionmentioning

confidence: 99%

“…There is preliminary evidence that early menopause may be associated with increased risk for several major ocular diseases, including glaucoma, which may be linked to ocular ischemia [30, 31]. In previous studies the effects of menopause and HRT on retrobulbar blood flow were not well defined [32, 33, 34, 35]. In this study, the effects of menopause and HRT on tear quality and quantity, IOP and retrobulbar blood flow were investigated.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Menopause and Hormone Replacement Therapy on Quality and Quantity of Tear, Intraocular Pressure and Ocular Blood Flow

et al. 2004

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Objective: To evaluate the effects of menopause and hormone replacement therapy (HRT) on the quality and amount of tear, intraocular pressure (IOP) and retrobulbar blood flow velocities. Patients and Methods: Twenty women aged between 40 and 50 years, free of ocular and systemic diseases and planning to receive HRT were recruited as the study group. Twenty-four healthy, age-matched but still menstruating women were enrolled as controls. On the first day of study basal and reflex Schirmer test, tear break-up time and IOP measurements (at 08.00, 12.00 and 16.00 h) were performed for all groups. On the second day of the study, the peak systolic velocity (PSV), end diastolic velocity (EDV) and resistivity index (RI) of the ophthalmic (OA), central retinal (CRA), nasal (NSPCA) and temporal short posterior ciliary (TSPCA) arteries were determined by color Doppler imaging. The menopausal group received HRT for 2 months, when all measurements were repeated for the 15 women who had received HRT on a daily basis. Results: The quality and amount of tear decreased (p < 0.01), IOP (p < 0.01) and RI of the CRA, TPCA and NPCA (p < 0.05) increased in postmenopausal women compared with the control group. After 2 months of HRT, the quality and amount of tear had increased (p < 0.001) and the IOP had decreased (p < 0.001). The PSV of the CRA and TSPCA had decreased (p < 0.05), as had the RI in the CRA (p < 0.001), NSPCA and TSPCA (p < 0.05). Conclusion: We conclude that age-induced changes on quality and amount of tear, IOP and retrobulbar blood flow are intensified by the menopause and that it may be possible to decrease the menopausal effects on these parameters by HRT.

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“…Harris et al (17) estudaram a circulação retrobulbar através do Doppler colorido de 125 voluntários sem alteração ocular, com idade entre 20 e 90 anos e encontraram aumento do índice de resistência da artéria ciliar curta posterior em pacientes do sexo feminino em relação à idade.…”

Section: Discussionunclassified

Análise discriminante dos pacientes portadores de glaucoma primário de ângulo aberto através do exame de Doppler colorido e do campo visual

Ramos¹,

Bergès²,

Prata³

et al. 2011

Arq. Bras. Oftalmol.

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Editorial Note: After completing the confidential analysis of the manuscript, ABO discloses, with her agreement, the name Dr. Ruth Rosenhek Schor as a reviewer. We thank her effort and expertise in participating in this process. RESUMOObjetivo: Determinar se as variáveis obtidas com exame Doppler colorido associadas às de campo visual são capazes de discriminar olhos normais de olhos glaucomatosos. Métodos: Foram avaliados prospectivamente 36 pacientes portadores de glaucoma primário de ângulo aberto em uso de medicação antiglaucomatosa (grupo glaucoma) e 20 voluntários normais (grupo controle). Analisou-se a distribuição dos grupos quanto ao sexo, idade, espessura corneana central, pressão intraocular, índices globais da perimetria computadorizada Octopus ("mean defect" e "loss variance") e os parâmetros do Doppler colorido (velocidade sistólica máxi-ma e índice de resistência). Resultados: Não houve diferença estatística significativa entre os grupos em relação à idade, espessura corneana e pressão intraocular. A análise discriminante mostrou que as variáveis: índice de resistência (IR) da artéria ciliar curta posterior (ACCP), "mean defect" (MD) e "loss variance" (LV) apresentaram influência estatisticamente significativa para o diagnóstico positivo de glaucoma. A função discriminante obtida foi: -3,637 + 0,109 MD + 0,028 LV + 4,325 IR ACCP. A probabilidade do diagnóstico positivo do glaucoma a partir do "score" -1,61 foi de 90%. Conclusão: Foi possível identificar através da análise discriminante, quais das variáveis do Doppler colorido que, associados às do campo visual, permitiram diferenciar pacientes glaucomatosos de normais. Essas variáveis foram: índice de resistên-cia da artéria ciliar curta posterior e índices da perimetria computadorizada "mean defect" e "loss variance". Descritores INTRODUÇÃOO diagnóstico do glaucoma baseia-se na história clínica, tonometria (medida da pressão intraocular), gonioscopia, avaliação da cabeça do nervo óptico, avaliação da camada de fibras nervosas da retina e avaliação do campo visual (1,2) . Entretanto, algumas vezes, esta propedêutica não permite a diferenciação entre suspeitos e glaucomatosos. Desta forma, diversas propedêuticas e estratégias têm sido desenvolvidas no intuito de permitir o diagnóstico mais preciso e precoce do glaucoma. Dentre elas, destacam-se modernas técnicas para avaliação anatômica ou funcional das estruturas envolvidas no dano glaucomatoso (3)(4)(5)(6) .Dentre as novas propedêuticas para avaliação funcional, especial atenção recai sobre o Doppler colorido que permite a avaliação da circulação sanguínea retrobulbar. O Doppler colorido é um mé-todo de imagem não invasivo que associa a ecografia modo B em tempo real à técnica Doppler, permitindo assim a análise das características do fluxo sanguíneo dos vasos retrobulbares (7)(8)(9)(10)(11)(12) . Birinci et al. (11) e Rankin et al. (13) estudaram pacientes com glaucoma primário de ângulo aberto (GPAA) com pressão intraocular (PIO) controlada (PIO <21 mmHg) com medicação tópica e encontraram uma...

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Aging Affects the Retrobulbar Circulation Differently in Women and Men

Cited by 107 publications

References 27 publications

Ocular haemodynamics in pseudoexfoliative and primary open-angle glaucoma

Ocular haemodynamics in pseudoexfoliative and primary open-angle glaucoma

The Effects of Menopause and Hormone Replacement Therapy on Quality and Quantity of Tear, Intraocular Pressure and Ocular Blood Flow

Análise discriminante dos pacientes portadores de glaucoma primário de ângulo aberto através do exame de Doppler colorido e do campo visual

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