Aggressive surgical and chemotherapeutic treatment of advanced pancreatoblastoma associated with tumor thrombus in portal vein

Yonekura, Takeo; Hokim, Masanori; Hirooka, Shinji; Kitayama, Hitoshi; Kubota, Akio

doi:10.1016/j.jpedsurg.2005.11.071

Cited by 33 publications

(17 citation statements)

References 9 publications

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“…This serologic marker can thus be used as an indicator of response to treatment [36]. Most children present with an incidental large abdominal mass that is often unresectable at diagnosis [37][38][39], a finding confirmed by our case series. Our patient presented with a large abdominal mass with vascular invasion that was unresectable at diagnosis.…”

Section: Discussionsupporting

confidence: 77%

Pancreatic surgery for tumors in children and adolescents

Casamassima¹,

Gause²,

Goldstein³

et al. 2016

Pediatr Surg Int

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Section: Discussionsupporting

confidence: 77%

Pancreatic surgery for tumors in children and adolescents

Casamassima¹,

Gause²,

Goldstein³

et al. 2016

Pediatr Surg Int

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“…The histopathologic findings in these cases were duct cell carcinoma [1][2][3][4], non-functioning islet cell tumor [5][6][7][8][9], malignant functioning islet cell tumor [10], solid-pseudopapillary tumor [11,12], intraductal papillary-mucinous carcinoma [13] and pancreatoblastoma [14]. Only one case of acinar cell carcinoma has been reported so far [15] (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…On physical examination he felt tenderness in the left upper quadrant. Laboratory data on admission were as follows: serum lactate dehydrogenase 523 IU/L (normal 120-230), alkaline phosphatase 330 IU/L (150-320), total cholesterol 129 mg/dL (140-219), blood urea nitrogen 28.5 mg/dL (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), blood glucose 91 mg/dL (70-110), amylase 84 IU/L (50-160), lipase 585 IU/L (11-53), elastase-1 [5,000 ng/dL (100-400), phospholipase A2 5,250 ng/dL (130-400), trypsin [900 ng/dL (110-460). Carcinoembryonic antigen, carbohydrate antigen 19-9, DUPAN-2, and alpha-fetoprotein were all normal.…”

Section: Case Reportmentioning

confidence: 99%

A case of acinar cell carcinoma of the pancreas that formed extensive tumor thrombus of the portal vein

Igarashi¹,

Shinozaki²,

Mukada

2008

Clin J Gastroenterol

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A 58-year-old man was admitted to our hospital because of anorexia and back pain. He had been previously diagnosed with chronic pancreatitis with blood thrombus of the splenic vein at another hospital. Abdominal ultrasonography and computed tomography revealed a large mass in the body and tail of the pancreas, which directly invaded the stomach and the spleen. Small nodular metastases in both lungs were also detected. Furthermore, tumor thrombus continuously involved the splenic and proximal superior mesenteric vein, main portal vein, and its right intrahepatic branch. A metastatic mass was disclosed in the adjacent liver. The specimens obtained from portal tumor thrombus were histologically compatible with acinar cell carcinoma. Portal tumor thrombus is a rare condition in pancreatic tumors; however, it seems to be important to differentiate tumor thrombus from blood thrombus of the portal vein in order to know the true clinical stage and provide a suitable treatment.

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“…In advanced pancreatic tumors, including cases of pediatric pancreatoblastoma, tumor invasion and thrombosis of the portal venous system have been reported and are characteristic findings which point to the diagnosis. [34] In retrospect, the presence of thrombosis in the splenoportal venous axis along with the raised serum AFP levels and the CT findings of an upper abdominal, retroperitoneal mass should have avoided the initial misdiagnosis in our patient and pancreatoblastoma should be in differential diagnosis.…”

mentioning

confidence: 85%