Pancreatic surgery for tumors in children and adolescents

Casamassima, Maria Grazia Sacco; Gause, Colin D.; Goldstein, Seth D.; Meoded, Avner; Lukish, Jeffrey R.; Wolfgang, Christopher L.; Cameron, John L.; Hackam, David J.; Hruban, Ralph H.; Colombani, Paul M.

doi:10.1007/s00383-016-3925-y

Cited by 33 publications

(47 citation statements)

References 47 publications

(62 reference statements)

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“…After screening titles and abstracts, 50 studies were retrieved for full‐text evaluation. Ultimately, 32 papers reporting on a total of 489 pediatric patients with pancreatic tumors satisfied predetermined search criteria and were included in this systematic review (Figure ) . Nine studies were conducted in the United States, five in Korea, four in Canada, and the rest of them came from Europe and Japan.…”

Section: Resultsmentioning

confidence: 99%

“…Although not universally accepted, several factors have been associated with metastatic potential, namely male sex, venous invasion, nuclear atypia, high mitotic index, the presence of necrobiotic cells, and tumor rupture caused by external trauma or intraoperative manipulation . In this systematic review, nearly 99% of the patients with SPTs were alive during a mean follow‐up of 51 months and only three fatal cases were identified (i.e., a locally advanced SPT with distant lymph node spread; a 15‐year‐old female who developed peritoneal carcinomatosis secondary to a concurrent rectal adenocarcinoma; a patient with liver metastasis at presentation who died 14 months after surgery despite receiving adjuvant chemoradiation).…”

Section: Discussionmentioning

confidence: 95%

“…Ultimately, 32 papers reporting on a total of 489 pediatric patients with pancreatic tumors satisfied predetermined search criteria and were included in this systematic review ( Figure 1). [3][4][5][6][7] Nine studies were conducted in the United States, 3,6,7,16,22,23,31,35,39 five in Korea, 13,20,26,28,29 four in Canada, 4,19,21,34 Data regarding history of prior trauma, pancreatitis, and underlying genetic syndromes as well as measurement of preoperative tumor biomarkers were not available in most studies. Supplementary Table S2 summarizes the demographics of systematically reviewed studies and Table 1 provides an overview of the clinicopathological characteristics of pediatric and adolescent patients with pancreatic tumors stratified by histologic subtype.…”

Section: Article Selection and Patient Demographicsmentioning

confidence: 99%

“…Published literature on pediatric pancreatic tumors is limited and mainly consists of relatively small case series and registry studies . In a recent analysis of the Surveillance, Epidemiology, and End Results (SEER) database, pancreatic neuroendocrine tumors (pNETs) were overall the most prevalent malignant pancreatic neoplasms of childhood, while pancreatoblastoma (PBL) was more common during the first decade of life .…”

Section: Introductionmentioning

confidence: 99%

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Solid pseudopapillary and malignant pancreatic tumors in childhood: A systematic review and evidence quality assessment

Mylonas

Doulamis²,

Tsilimigras

et al. 2018

Pediatric Blood & Cancer

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A systematic review of 32 studies reporting on 489 children with pancreatic tumors was performed. The most prevalent histologic subtype was solid pseudopapillary tumor (SPT) (61.3%). Pancreaticoduodenectomy was the most commonly performed operation (48%). Neoadjuvant chemo/radiotherapy was utilized in 3.9, 36.2, 25, and 27.8% of patients with SPTs, pancreatoblastomas (PBLs), neuroendocrine tumors, and exocrine carcinomas, respectively. Adjuvant chemotherapy (75.6%) and radiation (34%) were most commonly utilized in PBLs. All-cause mortality was highest in exocrine carcinomas (50%). Overall, 98.8% of patients with SPTs survived. PBL exhibited the highest recurrence rate (14.7%) within a mean of 23.5 months.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 95%

Section: Article Selection and Patient Demographicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Solid pseudopapillary and malignant pancreatic tumors in childhood: A systematic review and evidence quality assessment

Mylonas

Doulamis²,

Tsilimigras

et al. 2018

Pediatric Blood & Cancer

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“…Fortunately, pancreatic masses are an extremely rare indication for EUS in children. Surgical series demonstrate a difference in the histology of neoplastic masses in children compared to the adult population [113,114]. In particular, solid pseudopapillary neoplasms and pancreatoblastoma, followed by pancreatic neuroendocrine tumors (pNETs), are more frequent.…”

Section: Endoscopic Ultrasoundmentioning

confidence: 99%

Pediatric Endoscopy, Update 2020

et al. 2019

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Optimal management of pediatric endoscopy requires a multidisciplinary approach. In most hospitals, endoscopy in pediatric patients is performed by conventional gastroenterologists and only a few centers have specialized pediatric gastroenterologists. This is due to the fact that the number of pediatric gastroenterologists is limited and not all of them are experienced in endoscopic techniques. However, there are also some pediatric centers offering a high-quality and high-volume endoscopy service provided by very experienced pediatric gastroenterologists. Up to now, the literature on pediatric endoscopy is rather sparse. In this article, we describe current knowledge and practice of endoscopic procedures in pediatric patients, which should be relevant for both the adult and pediatric gastroenterologists.

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Extra‐appendicular neuroendocrine tumors: A report from the TREP project (2000‐2020)

Virgone

Ferrari

Chiaravalli

et al. 2021

Pediatric Blood & Cancer

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Background Extra‐appendicular neuroendocrine tumors (NETs) are very rare tumors. While diagnostic and therapeutic guidelines are well established for adults, data on children and adolescents are lacking. Patients and Methods Patients with a diagnosis of extra‐appendicular NET registered on the Tumori Rari in Età Pediatrica ‐ Rare Tumors in Pediatric Age (TREP) from 2000 to 2020 were analyzed. Clinical characteristics including patients’ presentation, tumor features, treatment, and outcome were reviewed. Results Twenty‐seven patients with extra‐appendicular NET registered on TREP with a median age of 173 months. The primary site was the pancreas (12) or bronchi (10) in the majority of cases. Other primary sites included the thymus, Meckel's diverticulum, and liver. Thirteen (48%) of tumors extended beyond the organ of origin: four invaded neighboring organs and/or regional nodes and nine involved distant metastases. The 3‐year event‐free survival (EFS) for those with localized disease was superior to those with metastatic disease (66.6% 95% CI 5‐95% vs 33% 95% CI 5‐68%, respectively; P = .005). A complete resection was feasible in 17 patients. The 3‐year EFS in these patients was superior to those with no or incomplete resection (R0 vs R1/R2, respectively; P = .007). Overall, 16 children had no evidence of disease at follow‐up, and one is alive with disease; five died, and five were lost to follow‐up. Conclusions Data from our experience demonstrated a wide heterogeneity of presentation and outcome of these tumors. Localized disease and complete surgical resection were the main prognostic factors of good outcome. Other therapies may have a role in prolonging survival in metastatic disease.

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Pancreatic surgery for tumors in children and adolescents

Cited by 33 publications

References 47 publications

Solid pseudopapillary and malignant pancreatic tumors in childhood: A systematic review and evidence quality assessment

Solid pseudopapillary and malignant pancreatic tumors in childhood: A systematic review and evidence quality assessment

Pediatric Endoscopy, Update 2020

Extra‐appendicular neuroendocrine tumors: A report from the TREP project (2000‐2020)

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