Aggressive retinal vasculitis in polyarteritis nodosa

Curi, André Luiz Land; Freeman, Gwenyth; Pavésio, Carlos

doi:10.1038/eye.2001.68

Cited by 13 publications

(6 citation statements)

References 4 publications

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“…In the London series, 6 patients or 4% had a systemic vasculitis, three with PAN and 3 with Granulomatosis with polyangiitis’s. Although one can find anecdotal reports of either polyarteritis nodosa or granulomatosis with polyangiitis affecting the retinal vessels (8–11), the largest case series of which we are aware illustrating these associations includes only four patients. Gallagher et.…”

Section: Discussionmentioning

confidence: 96%

Patients with Retinal Vasculitis Rarely Suffer from Systemic Vasculitis

Rosenbaum

Ali

et al. 2012

Seminars in Arthritis and Rheumatism

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Objectives Systemic vasculitis is often mistakenly assumed to be a common cause of retinal vasculitis. We sought to determine the relationship between retinal vasculitis and systemic vasculitis. Methods A selected review was performed on 1390 charts of patients attending the uveitis clinic at the Oregon Health & Science University between 1985 and 2010. Included in the review were all patients with diagnoses commonly associated with retinal vasculitis and all patients who were diagnosed with a systemic vasculitis. Retinal vasculitis was identified by perivascular exudates, intraretinal hemorrhage, or cotton wool spots as seen on clinical examination or by vascular occlusion or leakage as identified by fluorescein angiogram. Results 207 or 14.9% of patients with uveitis had retinal vasculitis as a component of the intraocular inflammation. Thirty-five patients had retinal vasculitis which was primary, i.e. not associated with a systemic disease, and the dominant manifestation of the uveitis. Fourteen of the patients with retinal vasculitis had Behcet’s disease. Only 11 of the 1390 patients with uveitis had a systemic vasculitis. Of these 11, four had retinal vasculitis including one secondary to a CMV retinitis. Thus, systemic vasculitis was directly responsible for 1.4% or 3 of 207 cases of retinal vasculitis. No-vasculitic systemic diseases such as sarcoidosis (n=13), syndromes confined to the eye such as pars planitis (n=36), and intraocular infections (n=29) were far more common causes of retinal vasculitis. Conclusion Retinal vasculitis is a relatively common feature of uveitis. Patients with retinal vasculitis, however, rarely suffer from one of the classical systemic vasculitides.

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Section: Discussionmentioning

confidence: 96%

Patients with Retinal Vasculitis Rarely Suffer from Systemic Vasculitis

Rosenbaum

Ali

et al. 2012

Seminars in Arthritis and Rheumatism

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“…The disease also may involve choroidal vessels [14,17,34,35]. Curi et al [36] reported aggressive retinal vasculitis involving both arteries and veins in a patient with polyarteritis nodosa.…”

Section: Cotton-wool Spotsmentioning

confidence: 99%

A clinical approach to the diagnosis of retinal vasculitis

2009

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Retinal vasculitis is a sight-threatening inflammatory eye condition that involves the retinal vessels. Detection of retinal vasculitis is made clinically, and is confirmed with the help of fundus fluorescein angiography. Active vascular disease is characterized by exudates around retinal vessels resulting in white sheathing or cuffing of the affected vessels. In this review, a practical approach to the diagnosis of retinal vasculitis is discussed based on ophthalmoscopic and fundus fluorescein angiographic findings.

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“…The disease also may involve choroidal vessels. 111−113 Recently, Curi et al 114 reported aggressive retinal vasculitis involving both arteries and veins in a patient with polyarteritis nodosa. Current therapy usually consists of corticosteroids and cyclophosphamide.…”

Section: Polyarteritis Nodosamentioning

confidence: 99%

Retinal Vasculitis

El‐Asrar

Herbort

Tabbara

2005

Ocular Immunology and Inflammation

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Retinal vasculitis is a sight-threatening intraocular inflammation affecting the retinal vessels. It may occur as an isolated ocular condition, as a manifestation of infectious or neoplastic disorders, or in association with a systemic inflammatory disease. The search for an underlying etiology should be approached in a multidisciplinary fashion based on a thorough history, review of systems, physical examination, and laboratory evaluation. Discrimination between infectious and noninfectious etiologies of retinal vasculitis is important because their treatment is different. This review is based on recently published articles on retinal vasculitis and deals with its clinical diagnosis, its link with systemic diseases, and its laboratory investigation.

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Aggressive retinal vasculitis in polyarteritis nodosa

Cited by 13 publications

References 4 publications

Patients with Retinal Vasculitis Rarely Suffer from Systemic Vasculitis

Patients with Retinal Vasculitis Rarely Suffer from Systemic Vasculitis

A clinical approach to the diagnosis of retinal vasculitis

Retinal Vasculitis

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