Aggressive Conjunctival Squamous Cell Carcinoma in Three Young Africans

Lewallen, Susan; Shroyer, Kenneth R.; Keyser, Robert B.; Liomba, George N.

doi:10.1001/archopht.1996.01100130209021

Cited by 32 publications

(7 citation statements)

References 14 publications

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“…In patients who have AIDS, several studies describe an aggressive form of squamous cell carcinoma in the conjunctiva and/or eyelids. 8,9 One 33year old male patient diagnosed with squamous cell carcinoma of the lid, had presented with a three month history of a spontaneously occurring non-healing ulcer of the left lower lid margin and medial canthus.A 38 year old woman developed a very large papillomatous conjunctival lesion less than a month after surgery, at the supra corneal donor site, from where conjunctival graft had been removed to repair the defect in the contralateral eye following excision of a recurrent pterygium (Recurrent pterygium excision with conjunctival autograft). The patient thereafter tested positive for HIV-I.…”

Section: Resultsmentioning

confidence: 99%

Ocular aids: experience at the Guinness Ophthalmic unit, Kaduna , Nigeria

Kehinde

Samaila²,

Eni³

2006

Nigerian Journal of Surgical Research

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Objective: To determine the pattern of presentation of ocular manifestations in HIV/AIDS and the modes of management employed. Method: This collaborative, hospital based retrospective study between the Ophthalmology and Immunology units covered the period between January-December, 2004. Results: 1020 new patients were seen during this period with HIV/AIDS, of whom 125(12.3%) cases presented with some form of ocular complications, made up of 74 females (59.2%) and 51 males (40.8%). Herpes Zoster Ophthalmicus (HZO), was the commonest form of presentation in 87 (69.6%) patients, followed by ocular tumours in 17 (13.6%) patients and cotton-wool spots in 5 (4%) patients. Conclusion: There is still a great need for the definitive diagnoses of ocular lesions, and retinal lesions in particular as well as appropriate treatment of ocular HIV/AIDS.

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Section: Resultsmentioning

confidence: 99%

Ocular aids: experience at the Guinness Ophthalmic unit, Kaduna , Nigeria

Kehinde

Samaila²,

Eni³

2006

Nigerian Journal of Surgical Research

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“… 17 , 18 , 19 There are marked variations in the reported HPV prevalence rates in conjunctival carcinoma, ranging from 0% to 100%. 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 Whereas some studies have reported highest incidence of HPV, 21 , 24 others have shown no evidence of HPV infection in OSSN lesions. 20 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 These discrepancies show the more important role of UV exposure in OSSN development than HPV infection.…”

Section: Discussionmentioning

confidence: 99%

Survey of 274 patients with conjunctival neoplastic lesions in Farabi Eye Hospital, Tehran 2006–2012

Asadi-Amoli

Ghanadan

2015

Journal of Current Ophthalmology

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PurposeTo evaluate conjunctival epithelial neoplastic lesions in a 7-year period.Materials and methodsThe data of all primary cases of conjunctival neoplasia diagnosed in the Pathology Department of Farabi Eye Hospital were analyzed.ResultsThe patient group consisted of 179 (65.3%) males and 95 (34.6%) females, with an age range of 14–90 years and a mean age of 57.9 years. The most common primary conjunctival epithelial neoplastic lesion was invasive squamous cell carcinoma (SCC) (40.8%), followed by dysplasia (17%), papilloma (16.4%), In situ SCC (16%), actinic keratosis (7.3%), basal cell carcinoma (0.7%), xeroderma pigmentosum (0.7%), and mucoepidermoid carcinoma (0.3%). Of 274 lesions, 47 (17.1%) were benign, 159 (58%) were malignant, and 68 (24.8%) were precancerous. Compared to the results of a previous study of this center (1990–2004), the incidence of precancerous lesions has slightly increased whereas the incidence of SCC has decreased (22.1% vs. 24.8% and 59% vs. 40.8%, respectively).ConclusionSCC is the most common conjunctival epithelial neoplasm in this study, and its prevalence in males is nearly two times higher than in females. The high percentage of squamous cell carcinoma can likely be attributed to elevated sun exposure and ultraviolet light in Iran.

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“…33-35 It was estimated that the relative risk of conjunctival epithelial malignancies increased 13-fold in patients with acquired immune deficiency syndrome (AIDS) 1033-35 Some investigators have suggested that as many as 50% of patients, less than 50 years old, with a conjunctival neoplasm may have AIDS 34…”

Section: Discussionmentioning

confidence: 99%