Survey of 274 patients with conjunctival neoplastic lesions in Farabi Eye Hospital, Tehran 2006–2012

Abstract

PurposeTo evaluate conjunctival epithelial neoplastic lesions in a 7-year period.Materials and methodsThe data of all primary cases of conjunctival neoplasia diagnosed in the Pathology Department of Farabi Eye Hospital were analyzed.ResultsThe patient group consisted of 179 (65.3%) males and 95 (34.6%) females, with an age range of 14–90 years and a mean age of 57.9 years. The most common primary conjunctival epithelial neoplastic lesion was invasive squamous cell carcinoma (SCC) (40.8%), followed by dysplasia (17%), papilloma (16.4%), In situ SCC (16%), actinic keratosis (7.3%), basal cell carcinoma (0.7%), xeroderma pigmentosum (0.7%), and mucoepidermoid carcinoma (0.3%). Of 274 lesions, 47 (17.1%) were benign, 159 (58%) were malignant, and 68 (24.8%) were precancerous. Compared to the results of a previous study of this center (1990–2004), the incidence of precancerous lesions has slightly increased whereas the incidence of SCC has decreased (22.1% vs. 24.8% and 59% vs. 40.8%, respectively).ConclusionSCC is the most common conjunctival epithelial neoplasm in this study, and its prevalence in males is nearly two times higher than in females. The high percentage of squamous cell carcinoma can likely be attributed to elevated sun exposure and ultraviolet light in Iran.

Conjunctival Lesions: A 5-Year Basic Demographic Data and Clinicopathological Review in a Tertiary Eye Care Hospital

“…The prevalence of malignant conjunctival lesions in our study was 9%, comparable to the overall prevalence of malignant conjunctival lesions reported in previous studies [10,11,21]. In the current study, the most frequent malignant lesion was ocular surface squamous neoplasia (OSSN), which was observed in 5/10 adult specimens (50%), with no gender predilection; this finding is consistent with the findings of Elshazly and Aliakbar-Navahi et al [1,11], despite previous reports of a higher incidence of OSSN in males [7,[22][23][24]. The differences in the spectrum of OSSN could be attributed to racial and environmental factors, which was further illustrated in a study by Gichuhi et The clinical appearance of a lightly pigmented patch in a 30-year-old female that was excised without specific clinical diagnosis.…”

Clinical and histopathological evaluation of 312 excised conjunctival tumors

“…PAM z atypią rozpoznawano równie często u kobiet i u mężczyzn, PAM bez atypii natomiast częściej u mężczyzn (64%). W przypadku melanozy niezwykle ważne jest określenie atypii w badaniu histopatologicznym, ponieważ w od 12% do 50% przypadków PAM z atypią ma tendencję do transformacji w czerniaka (2,(13)(14)(15), podczas gdy PAM bez atypii nie wiąże się z ryzykiem transformacji nowotworowej (16). Niestety, klinicznie te zmiany są praktycznie nie do odróżnienia (16).…”

“…Rak płaskonabłonkowy i dysplazja nabłonka częściej występowały u mężczyzn (66,7% i 83,3%), to jest zgodne z wcześniejszymi raportami (1,8,16). Tłumaczy się to większym narażeniem na promieniowanie UV mężczyzn niż kobiet (18). Ta grupa pacjentów była również najstarsza -średnia wieku ponad 60 lat.…”

Update on Diagnosis and Management of Conjunctival Papilloma

“…The presence of HPV has indeed been detected on the fingers of patients (37.5% of females, n = 3; 69% of males, n = 9) with genital warts [40], however the association between conjunctival and genital/anal papillomas is not clear. In a study of 17 women with HPV-related cervical dysplasia, DNA of HPV 16 was detected in both limbal and cervical swabs by polymerase chain reaction (PCR) in 35% of the patients [6], although no conjunctival papillomas were present [41]. Another study reported that coexistent genital warts and conjunctival papillomas was seen in 4% of patients (3 out of 73) [3].…”