Aggregation processes and photophysical properties of chlorophyll a in aqueous solutions modulated by the presence of cyclodextrins

Phototoxicity and cytotoxicity of chlorophyll a/cyclodextrins complexes on Jurkat cells

“…In these experimental conditions the amount of Chl a solubilized in cellular medium is different for the four examined CDs. In particular it is evident from the absorbance value that, contrary to that observed in aqueous solution [8][9][10], the TRIMEB shows poor ability in solubilizing Chl a in the cellular medium. DIMEB and HP-γ-CD are able to carry in solution almost the same amount of Chl a.…”

“…The aggregation status of Chl a and the ability of CDs to solubilize the pigment in the cellular medium is different from that observed in water [8][9][10][11]. In particular TRIMEB, the permethylated cyclodextrin having the best ability to solubilize Chl a in water as monomer, is the one which works worst in the RPMI 1640 medium.…”

“…CDs having different cavity size and moities have been considered as delivery systems of Chl a in solution and the obtained supramolecular systems have been characterized by different techniques [8][9][10]. The results of these studies have shown that some CDs are suitable carriers of Chl a in water and the Chl a/CD systems have properties which make them very promising as potential sensitizers in PDT.…”

Cyclodextrin/chlorophyll a complexes as supramolecular photosensitizers

“…Therefore, the PDT-literature deals mainly with dyes having intense absorption bands between 600 and 800 nm [4,5]. For this reason our research activities were focused on the photochemical and photophysical characterization of porphyrins and chlorines, which present absorption maxima in this wavelength region, with the aim to develop a new class of sensitizers for biomedical applications [6][7][8][9]. In particular, these studies concern the use of cyclodextrins for solubilizing hydrophobic dye molecules in aqueous environment.…”

Using inclusion complexes for achieving second‐order advantage: A novel technique for cinnamic acid derivatives analysis with second‐order calibration methods

“…In the present study, the authors demonstrated an accurate, reliable, inexpensive, and simple way for producing second‐order data based on the formation of inclusion complexes between target CA analytes and cyclodextrins (CDs). Experimental outcomes confirmed that CAs could form the inclusion complex with CDs by noncovalent bonds . Dielectric properties of the environment are recognized to influence spectral and molecular properties of molecules, such as the intensity and the position of peaks in the spectra.…”