Aggregation Phenomena on the Ternary Ionic−Nonionic Surfactant System:  Didodecyldimethylammonium Bromide/Octyl-β-d-glucopyranoside/Water. Mixed Microaggregates, Vesicles, and Micelles

Abstract

The formation of a variety of mixed colloidal aggregates has been investigated on a ternary ionic−nonionic system constituted by (i) a double-chain cationic surfactant with a 12-carbon atom hydrophobic tail, didodecyldimethylammonium bromide (di-C12DMAB), (ii) a nonionic single-chain surfactant, octyl-β-d-glucopyranoside (OBG), and (iii) water. The study has been carried out by means of conductivity, ζ-potential, transmission electron microscopy (TEM), and cryogenic transmission electron microscopy (cryo-TEM) experiments on the highly diluted, very diluted, and moderately diluted regions. The formation of mixed microaggregates, prior to the appearance of mixed vesicles, has been undoubtly confirmed by conductivity, TEM, and ζ-potential results. The concentrations at which these mixed colloidal aggregates form, i.e., the mixed critical microaggregate concentration (CAC*), the mixed critical vesicle concentration (CVC*), and the mixed critical micelle concentration (CMC*), have been determined from conductivity data, while the ζ-potential experiments allow for the characterization of the aggregate/solution interface. The shape and size of the microaggregates and vesicles have been evaluated from TEM and cryo-TEM micrographs, respectively. All of the experimental evidence has been also analyzed in terms of the theoretical packing parameter, P.

Aggregation behavior in mixed system of double-chained anionic surfactant with single-chained nonionic surfactant in aqueous solution

“…According to the work of Lichtenberg et al [11], this process has been described by a three-stage model (vesicle saturation, formation of mixed micelles, and complete vesicle solubilization). Besides natural phospholipids, the interaction between nonionic surfactant and synthetic vesicle-forming double-chained surfactant has also attracted much attention, especially that of dialkyldimethylammonium bromide [12,13].…”

“…Both studies suggest that the replacement of the methyl end group of AOT with a phenyl influences the surfactant properties significantly. Then, according to the studies on phospholipids and dialkyldimethylammonium bromide [8][9][10]12,13], the addition of nonionic surfactant C 12 E 5 to AOT and SBPBS vesicles solution is expected to destroy the vesicles to some extent, which leads to the formation of mixtures of micelles and vesicles and other intermediate aggregates. Because the main difference between AOT and SBPBS is the end group of the hydrophobic chains, we expect to see how this diversity would affect the properties of AOT-C 12 E 5 and SBPBS-C 12 E 5 mixed surfactants.…”

Complexation behavior of mixed monolayer/mixed micelle formation between cationic noble surfactant-nonionic conventional surfactant in the presence of biocompatible polymer

“…The mixed micelles are often used in the technical, pharmaceutical, and biological fields since they work better than pure micelles [20,21]. The interaction and aggregation behavior of mixed surfactants in solution and at interfaces have been extensively studied using various techniques such as smallangle neutron scattering (SANS), surface tension, conductivity, fluorescence, cyclic voltammeter, and dynamic light scattering [22][23][24][25][26][27]. Mixtures containing nonionic surfactants are particularly appealing to the formulation technologists due to the surfactant properties including low foaming, superior fiber cleaning and tolerance to water hardness.…”

Modulation of Aggregation Behaviour of Amphiphlic Drug and Surfactant Mixture under the Influence of Neutral Polymer

“…It is well recognized that surfactant and polymer mixtures are increasingly being used in wide range of domestic, industrial and technological applications to improve its characteristics and these properties cannot be achieved by using polymer or surfactant alone [1][2][3][4][5] . The mixtures are in general aqueous-based; polymers are added to the systems to control rheology, stability and to manipulate surface adsorption.…”