Aggregation Enhanced Excimer Emission Supported, Monomeric Fluorescence Quenching of Dendritic Hyperbranched Polyglycerol Coupled 1-Pyrene Butyric Acid Lumophore as a Sensing Probe for Fe2O3 Nanoparticles

Philip, Sherin; Kuriakose, Sunny

doi:10.1007/s10895-019-02347-7

Cited by 9 publications

(10 citation statements)

References 38 publications

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“…23 A considerably weak intensity of 2 near 500 nm indicated that the packing of amphiphile 2 was looser than that of 1, demonstrating a negligible amount of pyrene as dimers in the excited state (excimers). 24 The selfassembling behavior of amphiphile 2 was further studied using a dynamic light scattering experiment that exhibited an average value of 150 nm (Figure 3b). This value is consistent with the diameter of spherical aggregates acquired from the TEM image (Figure 3c).…”

Section: Resultsmentioning

confidence: 99%

Selective Anticancer Materials by Self-Assembly of Synthetic Amphiphiles Based on N-Acetylneuraminic Acid

Hwang

Kim

Park

et al. 2022

ACS Appl. Mater. Interfaces

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N-Acetylneuraminic acid (Neu5Ac), one of the abundant types of sialic acid, is an emerging anticancer agent owing to its ability to target selectins in the plasma membrane of cancer cells. Considering the functionality of Neu5Ac, obtaining novel Neu5Ac-conjugated materials with a selective and an enhanced antitumor activity has remained a challenge. Herein, we report the supramolecular materials of three novel amphiphiles composed of Neu5Ac as a hydrophilic segment and pyrene or adamantane as a hydrophobic segment. The synthetic amphiphiles 1, 2, and 3 self-assembled into ribbons, vesicles, and irregular aggregates in an aqueous solution, respectively. Among the materials, vesicles of amphiphile 2 showed the most substantial selectivity toward cancer cells, followed by cell death due to the production of reactive oxygen species by the pyrene group. The dual advantage of Neu5Ac-selectivity and the pyrene-cytotoxicity of vesicles of amphiphile 2 can provide a strategy for effective anticancer materials.

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Section: Resultsmentioning

confidence: 99%

Selective Anticancer Materials by Self-Assembly of Synthetic Amphiphiles Based on N-Acetylneuraminic Acid

Hwang

Kim

Park

et al. 2022

ACS Appl. Mater. Interfaces

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“…The first three intense peaks—378 nm, 398 nm and 420 nm are characteristic emissions of pyrene monomers from PBA used for the fluorescent modification of starch and the weak peak broad one around 445 nm indicates a negligible amount of pyrene as dimers in the excited state (excimers) (Philip and Kuriakose 2019 ). The spectrum confirms the successful esterification between PBA and starch.…”

Section: Resultsmentioning

confidence: 99%

Photodynamic antifungal activity of a superparamagnetic and fluorescent drug carrier system against antibiotic-resistant fungal strains

Philip

Kuriakose

2021

Cellulose

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Graphic abstract Increased antimicrobial resistance demands the development of new antimicrobial agents with high potency. A wide variety of microbial systems are continuously subjected to mutations which ultimately results in antimicrobial resistance. The present study aimed at the fabrication of a nano drug delivery system which simultaneously is superparamagnetic, fluorescent, non-cytotoxic and antifungal. The developed system is an easily targetable and detectable tool owing to its superparamagnetic and fluorescent characteristics respectively. Superparamagnetic iron oxide nanoparticles stabilized by macromolecular starch have been incorporated into a fluorescently modified carrier system to get the final drug delivery system. The finally developed drug carrier system is found to be non-cytotoxic from the in vitro cytotoxicity studies performed against normal rat spleen cells. The photodynamic antifungal capability of the system was the premier concern of investigation of the present study. The antifungal studies were conducted against Histoplasma capsulatum and Trichophyton rubrum by well diffusion method and the results were compared with the activity of the antibiotic, griseofulvin. The minimum inhibitory concentration against each fungal strain was determined using broth dilution method. Supplementary Information The online version contains supplementary material available at 10.1007/s10570-021-04107-y.

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“…S1). 39 These characteristic fluorescence emission peak of PBA remains unchanged after conjugation with PLGA polymer in PLGA-PBA nanoparticles and PLGA-PBA@MTX nanoparticle when excited at 240 nm (Fig. 3a).…”

Section: Please Do Not Adjust Marginsmentioning

confidence: 93%

Electrospray-based synthesis of fluorescent poly(d,l-lactide-co-glycolide) nanoparticles for the efficient delivery of an anticancer drug and self-monitoring its effect in drug-resistant breast cancer cells

et al. 2020

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Aggregation Enhanced Excimer Emission Supported, Monomeric Fluorescence Quenching of Dendritic Hyperbranched Polyglycerol Coupled 1-Pyrene Butyric Acid Lumophore as a Sensing Probe for Fe2O3 Nanoparticles

Cited by 9 publications

References 38 publications

Selective Anticancer Materials by Self-Assembly of Synthetic Amphiphiles Based on N-Acetylneuraminic Acid

Selective Anticancer Materials by Self-Assembly of Synthetic Amphiphiles Based on N-Acetylneuraminic Acid

Photodynamic antifungal activity of a superparamagnetic and fluorescent drug carrier system against antibiotic-resistant fungal strains

Electrospray-based synthesis of fluorescent poly(d,l-lactide-co-glycolide) nanoparticles for the efficient delivery of an anticancer drug and self-monitoring its effect in drug-resistant breast cancer cells

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