Aggregation behaviour of tetracaine hydrochloride with Gemini surfactants and the formation of silver nanoparticles using drug-Gemini surfactants mixture

Srivastava, Anirudh; Thapa, Uttam; Saha, Mithu; Jalees, Mohammad

doi:10.1016/j.molliq.2018.12.006

Cited by 30 publications

(10 citation statements)

References 62 publications

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“…Such a combination helps us to monitor both hydrophilic (between anionic SDS and cationic Gemini) and hydrophobic (due to hydrocarbon chains) interactions operating between the surfactant molecules adsorbed on Au and Ag NPs. A Gemini surfactant is made up of two identical monomeric homologues connected usually at the level of the dimeric head group. − This unique molecular structure provides a Gemini surfactant with double hydrocarbon chains and double polar head groups with a much stronger ability to undergo both hydrophobic and hydrophilic interactions in comparison to their conventional monomeric homologues. − The amphipathic nature of Gemini surfactants also mimics several complex biological molecules such as phospholipids and biological surfactants. Thus, NP surface-adsorbed Gemini surfactant systems can be treated as models for bio-nanomaterials in biological applications.…”

Section: Introductionmentioning

confidence: 99%

Distinguishing Nanoparticle–Nanoparticle Interactions between Gold and Silver Nanoparticles Controlled by Gemini Surfactants: Stability of Nanocolloids

2021

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Nanoparticle–nanoparticle (NP–NP) interactions were studied by choosing oppositely charged colloidal suspensions of Au and Ag NPs. For this purpose, sodium dodecyl sulfate-stabilized Au NPs were titrated with a series of Gemini surfactant (i.e., 12-n-12 and 16-n-16)-stabilized Ag NPs to demonstrate the effect of head group and hydrophobic tail modifications on the Au–Ag NP interactions. The purpose of selecting Au and Ag NPs was to monitor and differentiate among their individual colloidal behaviors in the course of NP–NP interactions by simultaneously conducting UV–visible, size, and ζ potential measurements. All colloidal properties demonstrated a significant change in the event of Au–Ag NP complex formation during NP–NP interactions. Nanomaterial analysis indicated a high degree of inter-particle fusion among Au and Ag NPs with a high Au–Ag mole ratio for strongly interacting Au–Ag NPs systems but a low Au–Ag mole ratio for the systems where interactions were screened by modifying the molecular structure of Gemini surfactants. Results concluded that it is possible to screen or delay the NP–NP interactions even for strongly interacting systems simply by incorporating a non-polar spacer in the head group region or by increasing the length of hydrocarbon chains of the Gemini surfactant, thus producing colloidal suspensions with a longer shelf life and better industrial applicability.

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Section: Introductionmentioning

confidence: 99%

Distinguishing Nanoparticle–Nanoparticle Interactions between Gold and Silver Nanoparticles Controlled by Gemini Surfactants: Stability of Nanocolloids

2021

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“…A lot of work has been done to improve the problem associated with stability and biocompatibility of poorly soluble drugs [3][4][5][6][7][8]. There have been a very few strategies developed for improving the solubility of poorly soluble drugs which include their complexation with other surface-active substances like conventional surfactants, gemini surfactants and ionic liquids [5,[9][10][11][12]. To lower the hydrophobicity and increasing hydrophilicity of poorly soluble drugs, alternative solvents like ILs have been used.…”

Section: Introductionmentioning

confidence: 99%

Interfacial and antibacterial properties of imidazolium based ionic liquids having different counterions with ciprofloxacin

Siddiquee

Patel

Saraswat

et al. 2021

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…TCH is also available in combination with lidocaine that is used as a local anesthetic cream. In surgery or other similar procedure, TCH blocks the pain signals by nerve endings [ 11 , 12 ]. The interaction between the anesthetic molecule and lipid molecules of the biomembrane at the interface is responsible for the anesthetic action of the drug.…”

Section: Introductionmentioning

confidence: 99%

Mixed Micellization, Thermodynamic and Adsorption Behavior of Tetracaine Hydrochloride in the Presence of Cationic Gemini/Conventional Surfactants

Azum

Rub

Khan

et al. 2022

Gels

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In this approach, tensiometry and UV-visible techniques are used to determine the effect of cationic gemini and conventional surfactants on tetracaine hydrochloride (TCH), an anesthetic drug. We have estimated micellar, interfacial, and energetic constraints. To gain a deep understanding of their mixed association behavior, the outputs were examined using different theoretical models. The critical micelle concentration for single and mixed amphiphiles was estimated. The cmc values of mixed amphiphiles were found between the individual amphiphiles due to strong attractive interaction (synergism) between the components after mixing. The non-ideal behavior of mixtures was confirmed by the larger values of ideal cmc than the experimental cmc values. The negative values of interaction parameter (β) and values of activity coefficients less than unity indicate strong synergistic interaction between drug and surfactant. The stability of the mixed systems is demonstrated by the negative Gibbs free energy of micellization and excess free energy of micellization. In contrast to a single chain surfactant, a double chain surfactant (gemini) exhibits better interactions with the drug. Spectral measurements (UV-visible spectra) were used to monitor the binding of the drug with surfactant (conventional as well as gemini). Studying these mixed aggregates could help to optimize their compositions and find synergistic properties between TCH monomers and surfactants.

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Aggregation behaviour of tetracaine hydrochloride with Gemini surfactants and the formation of silver nanoparticles using drug-Gemini surfactants mixture

Cited by 30 publications

References 62 publications

Distinguishing Nanoparticle–Nanoparticle Interactions between Gold and Silver Nanoparticles Controlled by Gemini Surfactants: Stability of Nanocolloids

Distinguishing Nanoparticle–Nanoparticle Interactions between Gold and Silver Nanoparticles Controlled by Gemini Surfactants: Stability of Nanocolloids

Interfacial and antibacterial properties of imidazolium based ionic liquids having different counterions with ciprofloxacin

Mixed Micellization, Thermodynamic and Adsorption Behavior of Tetracaine Hydrochloride in the Presence of Cationic Gemini/Conventional Surfactants

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