Aggregation behavior of amphiphilic drug promazine hydrochloride and sodium dodecylbenzenesulfonate mixtures under the influence of NaCl/urea at various concentration and temperatures

Abstract

Micellization (aggregation) phenomenon of amphiphilic phenothiazine drug promazine hydrochloride (PMZ) and sodium dodecylbenzenesulfonate (SDBS) mixtures in absence and attendance of 50 mmol•kg À1 NaCl (salt)/300 mmol•kg À1 urea was investigated conductometrically at five various temperatures (293.15-318.15 K) at gaps of T = 5 K. PMZ is employed for the cure of mania and schizophrenia. The critical micelle concentration (CMC) values have been evaluated and defined in terms of hydrophobicity and hydrophilicity of PMZ and SDBS in aqueous and nonaqueous solutions. With increasing the temperature, the CMC first increases then decreases. At 303.15 K, the maximum CMC values were obtained in absence and presence of NaCl/urea. NaCl reduces the CMC of pure amphiphiles and their mixtures while urea increases. Various physicochemical parameters such as CMC id (ideal critical micelle concentration), micellar mole fraction of SDBS (X 1 ) (calculated by different proposed models), and interaction parameter have been evaluated and discussed in detail. The values of degree of dissociation (g) and CMC of the micelles were utilized to evaluate the different thermodynamic parameters. Activity coefficients (f 1 and f 2 ) and excess free energy of micellization (ΔG ex ) values were also evaluated. All outcomes obtained herein show attractive interactions in the mixtures of PMZ and SDBS.

Aggregation Behavior of Sodium Dodecyl Sulfate and Cetyltrimethylammonium Bromide Mixtures in Aqueous/Chitosan Solution at Various Temperatures: An Experimental and Theoretical Approach

“…Thermodynamic parameters can be utilized to understand the structural and environmental effects on the micellization. Thermodynamic parameters of pure amphiphiles (CTAB, SDS) and CTAB+SDS mixed systems in the absence/presence of chitosan were estimated by utilizing the subsequent equations (Kumar and Rub, ; Molla et al, ; Rub et al, ): …”

“…The values of entropy change of micellization () of pure SDS, CTAB, and their mixed system were found to be positive in the absence/presence of chitosan at all temperatures studied (Table ), suggesting that micellization of pure and mixed systems is an entropy‐dominated phenomenon. The values of pure SDS, CTAB, and SDS + CTAB were found to increase with the increase of temperature resulting from reduced hydrophobic hydration at higher temperatures (Kumar and Rub, ). The values reduce with the increase of the mole fraction of CTAB ( α 1 ), which signifies that mixed micelles are highly ordered at a higher mole fraction of CTAB.…”

Effect of temperature and salts on the interaction of cetyltrimethylammonium bromide with ceftriaxone sodium trihydrate drug

“…It can also be used to treat gonorrhea. Although a number of studies on the interaction of surfactants with different solute molecules including drugs are reported in the literature [3][4][5][6][7][8][9], to the best of our knowledge very little is known about the interaction of CFT with CTAB. In our previous papers, interaction of cephalosporin and beta lactum antibiotic drugs with ionic surfactants such as hexadecyltrimethylammonium bromide (HDTAB), dodecyltrimethylammonium bromide (DTAB), cetyldimethylethylammonium bromide (CDMEAB) and sodium dodecyl sulfate (SDS) in water and in aqueous solution of different salts were reported [4][5][6][7].…”

Effect of Various Electrolytes on the Phase Separation and Thermodynamic Properties of p‐Tert‐Alkylphenoxy Poly (Oxyethylene) Ether in the Absence/Presence of Drugs

“…The obtained positive values of in water are due to disruption of the H 2 O structure in the hydrophobic portion of the amphiphilic molecules (Naqvi et al, ). On the other hand, the negative values of arise when hydration of water molecules around the polar group of the amphiphilic molecules becomes more significant as compared to the rupture of the H 2 O molecules around the hydrophobic portion (Hoque et al, ; Khan et al, ; Kumar et al, ; Kumar and Rub, ).…”