Aggregation-based determination of mercury(II) using DNA-modified single gold nanoparticle, T-Hg(II)-T interaction, and single-particle ICP-MS

Xing, Yuqian; Han, Juan; Wu, Xu; Pierce, David T.; Zhao, Julia Xiaojun

doi:10.1007/s00604-019-4057-6

Cited by 25 publications

(12 citation statements)

References 41 publications

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“…It has been reported that AuNPs have high response values in ICP-MS and are easy to detect [ 29 , 30 ]. The AuNPs solution (5.0 × 10 5 units/mL) was analysed via ICP-MS.…”

Section: Resultsmentioning

confidence: 99%

Single-Molecule Detection of Nucleic Acids via Liposome Signal Amplification in Mass Spectrometry

Lin

Zhao

et al. 2022

Sensors

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A single-molecule detection method was developed for nucleic acids based on mass spectrometry counting single liposome particles. Before the appearance of symptoms, a negligible amount of nucleic acids and biomarkers for the clinical diagnosis of the disease were already present. However, it is difficult to detect extremely low concentrations of nucleic acids using the current methods. Hence, the establishment of an ultra-sensitive nucleic acid detection technique is urgently needed. Herein, magnetic beads were used to capture target nucleic acids, and liposome particles were employed as mass tags for single-particle measurements. Liposomes were released from magnetic beads via photocatalytic cleavage. Hence, one DNA molecule corresponded to one liposome particle, which could be counted using mass spectrometric measurement. The ultrasensitive detection of DNA (10–18 M) was achieved using this method.

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“…It has been reported that AuNPs have high response values in ICP-MS and are easy to detect [ 29 , 30 ]. The AuNPs solution (5.0 × 10 5 units/mL) was analysed via ICP-MS.…”

Section: Resultsmentioning

confidence: 99%

Single-Molecule Detection of Nucleic Acids via Liposome Signal Amplification in Mass Spectrometry

Lin

Zhao

et al. 2022

Sensors

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“…The developed Hg 2+ –SE offers much better features than the electrodes mentioned in the comparison. Moreover, the analytical performance of the proposed electrode in terms of sensitivity, recovery, and linear concentration range was compared with different analytical techniques [ 63 , 64 , 65 , 66 , 67 , 68 , 69 ]. The Hg 2+ –SE designed in the present study provides better performance than some of the methods mentioned in Table 6 without the need to use the extraction or preconcentration methodology.…”

Section: Resultsmentioning

confidence: 99%

Design and Characterization of Electrochemical Sensor for the Determination of Mercury(II) Ion in Real Samples Based upon a New Schiff Base Derivative as an Ionophore

Alharthi

Fallatah

Al-Saidi

2021

Sensors

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The present paper provides a description of the design, characterization, and use of a Hg2+ selective electrode (Hg2+–SE) for the determination of Hg2+ at ultra-traces levels in a variety of real samples. The ionophore in the proposed electrode is a new Schiff base, namely 4-bromo-2-[(4-methoxyphenylimino)methyl]phenol (BMPMP). All factors affecting electrode response including polymeric membrane composition, concentration of internal solution, pH sample solution, and response time were optimized. The optimum response of our electrode was obtained with the following polymeric membrane composition (% w/w): PVC, 32; o-NPOE, 64.5; BMPMP, 2 and NaTPB, 1.5. The potentiometric response of Hg2+–SE towards Hg2+ ion was linear in the wide range of concentrations (9.33 × 10–8−3.98 × 10–3 molL–1), while, the limit of detection of the proposed electrode was 3.98 × 10–8 molL–1 (8.00 μg L–1). The Hg2+–SE responds quickly to Hg2+ ions as the response time of less than 10 s. On the other hand, the slope value obtained for the developed electrode was 29.74 ± 0.1 mV/decade in the pH range of 2.0−9.0 in good agreement with the Nernstian response (29.50 mV/decade). The Hg2+–SE has relatively less interference with other metal ions. The Hg2+–SE was used as an indicator electrode in potentiometric titrations to estimate Hg2+ ions in waters, compact fluorescent lamp, and dental amalgam alloy and the accuracy of the developed electrode was compared with ICP–OES measurement values. Moreover, the new Schiff base (BMPMP) was synthesized and characterized using ATR–FTIR, elemental analysis, 1H NMR, and 13C NMR. The PVC membranes containing BMPMP as an ionophore unloaded and loaded with Hg(II) are reported by scanning electron microscope images (SEM) along with energy-dispersive X-ray spectroscopy (EDX) spectra.

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“…1,2 Excessive accumulation of Hg 2+ ions in the human body may trigger various diseases such as pneumonia, renal failure, motion disorders, minamata disease, and endocrine system damage. 3–5 To date, various analytical detection methods have been developed for analyzing Hg 2+ ions, including fluorescence analysis, 6,7 surface-enhanced Raman scattering spectrometry, 8 electrochemical assay, 9 inductively coupled plasma mass spectrometry, 10 atomic absorption spectrometry, 11 and colorimetric methodology. 12 Among these detection methods, the colorimetric analysis methods can show some inherent advantages such as high sensitivity, signal visibility, simplicity of operation, rapid response, and availability for on-site detection.…”

Section: Introductionmentioning

confidence: 99%

Covalent organic framework-loaded silver nanoparticles as robust mimetic oxidase for highly sensitive and selective colorimetric detection of mercury in blood

Liu

Chu

et al. 2022

J. Mater. Chem. B

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Aggregation-based determination of mercury(II) using DNA-modified single gold nanoparticle, T-Hg(II)-T interaction, and single-particle ICP-MS

Cited by 25 publications

References 41 publications

Single-Molecule Detection of Nucleic Acids via Liposome Signal Amplification in Mass Spectrometry

Single-Molecule Detection of Nucleic Acids via Liposome Signal Amplification in Mass Spectrometry

Design and Characterization of Electrochemical Sensor for the Determination of Mercury(II) Ion in Real Samples Based upon a New Schiff Base Derivative as an Ionophore

Covalent organic framework-loaded silver nanoparticles as robust mimetic oxidase for highly sensitive and selective colorimetric detection of mercury in blood

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