Aggregation and Cell Surface Receptors in Cellular Slime Molds

Newell, Peter C.

doi:10.1007/978-1-4615-9698-1_1

Cited by 20 publications

(11 citation statements)

References 128 publications

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“…The amoebae are attracted into the centres by pulses of cyclic AMP that are rhythmically emitted by amoebae at the centres (see reviews by Newell, 1977Newell, ,1978Darmon & Brachet, 1978). Theoretical models have been proposed that account for pulsatile release of cyclic AMP in terms of feed-back loops whose excitability can be raised to the point of autonomous generation of cyclic AMP pulses (Keller & Segel, 1970;Durston, 1973;Goldbeter & Erneux, 1978;Goldbeter & Segel, 1980).…”

Section: Introductionmentioning

confidence: 99%

Inhibition by Adenosine of Aggregation Centre Initiation and Cyclic AMP Binding in Dictyostelium

Newell

Ross

1982

Microbiology

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The inhibitory action of adenosine on the initiation of aggregation centre formation in starving Dictyostelium discoidem was examined and used to test assumptions of theoretical models of cyclic AMP signalling. Adenosine at 5 mM strongly inhibited aggregation centre initiation without preventing signal relay. Inosine or AMP at 10 mM had no effect and did not prevent the effect of adenosine. Adenosine had no effect on cellular phosphodiesterase activity, contact site A formation, or chemotaxis to small drops of cyclic AMP. The chemotactically-related responses of rapid cyclic GMP formation and changes in light scattering after pulses of cyclic AMP did not show any inhibition or decrease in sensitivity to the signal in the presence of adenosine. However, binding of 3H-labelled cyclic AMP to cell surface receptors was strongly inhibited by adenosine. The maximum inhibition was approximately 90% and was non-competitive with respect to cyclic AMP. The role of cell surface cyclic AMP receptors in the mechanism of initiation and the implications of the effects of adenosine for the role of cyclic GMP as a secondary messenger are discussed.

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Section: Introductionmentioning

confidence: 99%

Inhibition by Adenosine of Aggregation Centre Initiation and Cyclic AMP Binding in Dictyostelium

Newell

Ross

1982

Microbiology

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“…The cellular slime moulds are currently exciting considerable attention from biologists because of their relatively simple programme of differentiation that is triggered by starvation (reviewed by Loomis, 1975) and because of their unusual aggregative phase during which cell communication occurs over large distances by means of a pulsatile chemical signalling system (reviewed by Newell, 1977).…”

Section: Introductionmentioning

confidence: 99%

Genetics of Aggregation Pattern Mutations in the Cellular Slime Mould Dictyostelium discoideum

Ross

Newell

1979

Journal of General Microbiology

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A class of aggregation pattern mutants called ' streamers ' have been isolated from Dictyostelium discoideum and analysed genetically. The streamer phenotype is the formation of very large streams of centripetally moving amoebae which are collected from abnormally large territories during the aggregation phase of this organism. Such mutants do not show the pleiotropic developmental defects seen with most other classes of aggregation mutants and after the abnormal aggregation phase they develop into normally differentiated stalk cells and spores. Twenty-four haploid streamers were isolated and assigned to seven complementation groups, stmA to stmG, after selecting diploids formed between pairs of the mutants. The complementation loci were assigned to the following linkage groups using parasexual genetic techniques: stmA and stmF, linkage group VII; stmB, stmD and stmG, linkage group 11; stmC and stmE, linkage group 111. Use was made of a new temperature sensitive for growth marker, tsgK21, which was assigned to linkage group VII. The total number of complementation groups giving the streamer phenotype is estimated from statistical calculation, based on the frequency of allelism, to be between seven and nine.

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“…The most important refinement was probably the origin of receptors (Newell 1977). Receptors would enable signals to work their effect without having to enter a cell, allowing for increased efficiency and specificity.…”

Section: Eventually Better Dispersalmentioning

confidence: 99%

The evolution of communication and social behaviour inDictyostelium discoideum

Nanjundiah

1985

Proc Ani Sci

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Exceptionally for a developing system, the pathways of intercellular communication are fairly well characterised in the cellular slime molds. This paper attempts to provide adaptive explanations for the origin of the following features and consequences of communication between cellular slime mold cells: the tendency to congregate, chemotaxis to a released signal, signal relay from cell to cell, oscillatory signal release and an invariant ratio of the terminally differentiated cell types. For the sake ofspecificity attention is directed at the species DictyostelilUll discoidelUll. Central to the entire analysis is the assumption that contiguous groups of feeding cells are, and in the past were, genetically identical. It is suggested that, in respect of most of the features listed above, the critical event which started things off must have been the acquisition by the cell membrane of permeability for a substance normally produced intracellularly as a response to the stress of starvation. An argument is presented for treating social behaviour in these organisms, and in particular the suicide by cells which differentiate into stalk, as an example of group selection.-

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Aggregation and Cell Surface Receptors in Cellular Slime Molds

Cited by 20 publications

References 128 publications

Inhibition by Adenosine of Aggregation Centre Initiation and Cyclic AMP Binding in Dictyostelium

Inhibition by Adenosine of Aggregation Centre Initiation and Cyclic AMP Binding in Dictyostelium

Genetics of Aggregation Pattern Mutations in the Cellular Slime Mould Dictyostelium discoideum

The evolution of communication and social behaviour inDictyostelium discoideum

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