Agglomeration in suspension of salicylic acid fine particles: Analysis of the wetting period and effect of the binder injection mode on the final agglomerate size

Subero-Couroyer, C.; Mangin, Denis; Rivoire, Alain; Blandin, A; Klein, Jean Paul

doi:10.1016/j.powtec.2005.08.014

Cited by 37 publications

(36 citation statements)

References 17 publications

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“…Within the critical BSR range, Blandin et al [39] reported that the size of the final agglomerates of salicylic acid significantly increased with increasing BSR. This finding has also been observed in studies by Subero-Couroyer et al [36], Thati and Rasmuson [37,46] and Bos and Zuiderweg [57]. It was found that increasing the BSR leads to higher agglomerate deformability.…”

Section: Figsupporting

confidence: 84%

“…It was found that increasing the BSR leads to higher agglomerate deformability. This results in more energy dissipation during collisions and an increase in agglomeration efficiency, ultimately yielding larger agglomerates [36]. Furthermore, Thati and Rasmuson [37] noted an improvement in agglomerate morphology as the BSR increases, yielding highly spherical agglomerates.…”

Section: Figmentioning

confidence: 99%

“…The amount of bridging liquid added to the spherical agglomeration system can have a significant impact on the process, and it has often been stated as being the most influential parameter affecting the final product [9,36,39,47,48]. Indeed, the importance of the amount of bridging liquid was specifically highlighted in a study by Blandin et al [39] during an investigation into the effect of operating parameters on final agglomerate mean size.…”

Section: Effect Of the Amount Of Bridging Liquidmentioning

confidence: 99%

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Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling

et al. 2018

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Section: Figsupporting

confidence: 84%

Section: Figmentioning

confidence: 99%

Section: Effect Of the Amount Of Bridging Liquidmentioning

confidence: 99%

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Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling

et al. 2018

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“…The third solvent used in the process is bridging liquid, which connects the wetted particles by the formation of liquid bridges resulting in the formation of spherical crystal agglomerates (Pitt et al, 2018). This increases the particle size and contributes for direct tabletting due to enhancement incompressibility and micromeritic characteristics (Subero-Couroyer et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

“…(Pitt et al, 2018) This increased the particle size and contributes for direct tabletting due to enhancement incompressibility and micromeritic characteristics. (Subero-Couroyer et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Development, characterization and solubility enhancement of poorly water soluble drug telmisartan by polymer enriched bridging liquid technique using peg 4000 as hydrophilic polymer

Manoj

Seenivasan

Arul

et al. 2019

ijrps

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The solubility and bioavailability enhancement of poorly water soluble drugs has been a foremost challenge in formulation development. Telmisartan belonging to Angiotension II receptor antagonist, extensively used candidate for the treatment of hypertension possess poor water solubility and bioavailability. Polymer Enriched Bridging Liquid (PEBL) method was adopted here for enhancing the flow properties and solubility of Telmisartan. The techniques involve the incorporation of a hydrophilic polymer, PEG4000 into the bridging liquid during the crystallisation process. The drug content determination suggested the better incorporation of polymer into the crystal aggregates. The FTIR analysis showed the absence of any chemical interaction. The DSC analysis showed a significant reduction in the enthalpy and melting point. The crystallinity of Telmisartan was reduced from 50.789 to 34.655% indicated by the reduction in peak intensity analysis and peak area calculation by X-Ray diffraction. The SEM analysis revealed the spherical nature of crystals resulting in the improvement of flow properties. The saturation solubility analysis revealed that the formulation STPG03 has shown 25.86 fold increase in the solubility in water and 24.217 folds in pH7.5 Phosphate buffer. The in vitro dissolution data also supported the results of solubility analysis. Hence PEBL technique provided a better alternative to enhance the flow characteristics, solubility, dissolution and bioavailability of Telmisartan.

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Iterative model‐based experimental design for spherical agglomeration processes

et al. 2021

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Spherical agglomeration (SA) is a process intensification strategy, which can reduce the number of unit operations in pharmaceutical manufacturing. SA merges drug substance crystallization with drug product wet granulation, reducing capital, and operating costs. However, SA is a highly nonlinear process, thus for its efficient operation model‐based design and control strategies are beneficial. These require the development of a high‐fidelity process model with appropriately estimated parameters. There are two major problems associated with the development of a high‐fidelity process models—(i) selection of the appropriate model corresponding to the underlying process mechanisms, and (ii) accurate estimation of the parameters. This work focuses on the identification of the best fitting model that correlates with experimental observations using cross‐validation experiments. Further, an iterative model‐based experimental design strategy is developed, which uses D‐optimal experimental design criterion to minimize the number of experiments necessary to obtain accurate parameter estimates.

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Agglomeration in suspension of salicylic acid fine particles: Analysis of the wetting period and effect of the binder injection mode on the final agglomerate size

Cited by 37 publications

References 17 publications

Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling

Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling

Development, characterization and solubility enhancement of poorly water soluble drug telmisartan by polymer enriched bridging liquid technique using peg 4000 as hydrophilic polymer

Iterative model‐based experimental design for spherical agglomeration processes

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