Agglomeration during spray drying: Airborne clusters or breakage at the walls?

Francia, Victor; Martín, Luis; Bayly, Andrew E.; Simmons, Mark

doi:10.1016/j.ces.2016.12.033

Cited by 18 publications

(15 citation statements)

References 79 publications

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“…Comparing DSC thermal profiles of Batch-12 and Batch-3 (blank powders, Figure 3, dotted black and red line, respectively), proline showed an anticipation of melting peak probably due to the effect of agglomeration on P crystals [31,42], shifted by 8 Celsius degrees in Batch-15 (221.45 • C) with respect to Batch-13 (228.81 • C). This event was accompanied by a reduction of enthalpy, indicating a reduction in crystallinity.…”

Section: Thermal Analysesmentioning

confidence: 96%

“…Spray-dried Batch-3 showed a P interaction with HEC, involving in a spherical agglomeration process, without totally losing its crystalline state ( Figure 1c) [42] causing fractures and clusters on particles surface. Moreover, the loading with HSE further negatively affected the agglomeration process of the matrix system (Batch 13, Figure 1d).…”

Section: Microencapsulation Process Morphological and Dimensional Cmentioning

confidence: 99%

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Design and Development of Spray-Dried Microsystems to Improve Technological and Functional Properties of Bioactive Compounds from Hazelnut Shells

et al. 2020

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An extract obtained from hazelnut shells by-products (HSE) has antioxidant and chemopreventive effects on human melanoma and cervical cancer cell lines, inducing apoptosis by caspase-3 activation. A clinical translation is limited by poor water solubility and low bioavailability. Dried plant extracts often show critical characteristics such as sticky/gummy appearance, unpleasant smell, and instability involving practical difficulties in processing for industrial use. A spray drying method has been applied to transform raw HSE in a microparticulate powder. The biopolymeric matrix was based on l-proline as loading carrier, hydroxyethylcellulose in combination with pectin as coating polymers; lecithin and ethanol were used as solubility enhancers. A Hot-Cold-Hot method was selected to prepare the liquid feed. The thus prepared powder showed good technological properties (solid-state, particle dimensions, morphology, and water dissolution rate), stability, and unchanged chemopreventive effects with respect to the unprocessed HSE.

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Section: Thermal Analysesmentioning

confidence: 96%

Section: Microencapsulation Process Morphological and Dimensional Cmentioning

confidence: 99%

Design and Development of Spray-Dried Microsystems to Improve Technological and Functional Properties of Bioactive Compounds from Hazelnut Shells

et al. 2020

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“…It is indeed not evident whether impact-fragmentation plays a role in the case of large suspended particles while splashing effects can be negligible for colloids (due to their small kinetic energy). For example, recent studies in spray drying systems have shown that the impact of aggregates on surfaces leads to the break-up of clusters on the wall [23]. Besides, the effect of deposit restructuration needs to be further assessed in such experiments especially for colloidal particles.…”

Section: Saltation: Outcome Of Re-impact On the Surfacementioning

confidence: 99%

Particle resuspension from complex surfaces: current knowledge and limitations

Henry

2018

Preprint

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This review explores particle resuspension from surfaces due to fluid flows. The objective of this review is to provide a general framework and terminology for particle resuspension while highlighting the future developments needed to deepen our understanding of these phenomena. For that purpose, the manuscript is organized with respect to three mechanisms identified in particle resuspension, namely: the incipient motion of particles (i.e. how particles are set in motion), their migration on the surface (i.e. rolling or sliding motion) and their re-entrainment in the flow (i.e. their motion in the near-wall region after detachment). Recent measurements and simulations of particle resuspension are used to underline our current understanding of each mechanism for particle resuspension. These selected examples also highlight the limitations in the present knowledge of particle resuspension, while providing insights into future developments that need to be addressed. In particular, the paper addresses the issue of adhesion forces between complex surfaceswhere more detailed characterizations of adhesion force distributions are needed -and the issue of particle sliding/rolling motion on the surface -which can lead to particles halting/being trapped in regions with high adhesion forces.

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“…In this process the feed liquid is atomized in a drying chamber in which a turbulent hot air comes in contact with droplets. Consequently, droplet collisions occur and the outcomes of these collisions play an important role in the prediction of the tower performance and the product properties (Francia et al, 2017). A good understanding and accurate models of collision behavior is therefore important for the prediction of both process performance and product properties.…”

Section: Introductionmentioning

confidence: 99%

A new model for the bouncing regime boundary in binary droplet collisions

Al-Dirawi

Bayly

2019

Physics of Fluids

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This work experimentally investigates binary collisions of identical droplets over a range of liquid viscosities, using 2%, 4%, and 8% of hydroxypropyl methylcellulose (HPMC) solutions in water. The collisions were captured by a high-speed camera, and regime maps of collision outcomes derived. The performance of existing models of the boundary of the bouncing regime was assessed and found to give poor predictions. This was attributed to assumptions and errors in the treatment of kinetic energy and the droplet shape factors used in these models. A new model was derived which addresses these issues: the definition of the kinetic energy that contributes to deformation was corrected; a new shape factor that accurately reflects the geometry of the droplet at maximum deformation was proposed and, importantly, an empirical approach was implemented to account for the effect of the impact parameter on this shape factor. Moreover, the model includes an estimate of the viscous dissipation, which is calculated directly from experimentally observed difference between the impact and the rebound kinetic energies, and measurements of the post-collision droplet oscillations. The proposed model shows a striking improvement versus the existing models, reducing the mean absolute error by an order of magnitude.

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Agglomeration during spray drying: Airborne clusters or breakage at the walls?

Cited by 18 publications

References 79 publications

Design and Development of Spray-Dried Microsystems to Improve Technological and Functional Properties of Bioactive Compounds from Hazelnut Shells

Design and Development of Spray-Dried Microsystems to Improve Technological and Functional Properties of Bioactive Compounds from Hazelnut Shells

Particle resuspension from complex surfaces: current knowledge and limitations

A new model for the bouncing regime boundary in binary droplet collisions

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