The Conservation Reserve Program (CRP) is a cost-share and rental payment program signed into law by President Reagan in 1985 and administered by the Farm Service Agency (FSA) under the United State Department of Agriculture (USDA). CRP aims to counteract erosion and protect the environment by encouraging agricultural landowners to convert highly erodible cropland and other environmentally sensitive lands to native or alternative permanent vegetative cover through the implementation of 10-year contracts paying annual rents. CRP has been actively implemented since the enactment of the Food Security Act of 1985. Re-authorized by Congress in 1996 with major modifications, the CRP has been renewed with minor alterations several times. In 1998, the joint state/federal Conservation Reserve Enhancement Program (CREP) targeted the long-term retirement of an additional 40,469 ha (100,000 acres) of agricultural land in the Minnesota River basin to enhance water quality and wildlife habitat through permanent conservation easements.This research examines land use change from 1985 to 2013 in the Minnesota River Valley beginning with an era of no long-term set-asides to the current era with two active long-term set-aside conservation reserve programs. Multi-temporal remote sensing images from 1985, 1995, 2005 and 2013 were analyzed to map the land use changes in response to the CRP policy alterations. The results revealed more than 36,000 ha (89,000 acres) cropland have been converted to grassland or forest during this 28-year span. A persistent drop in cropland occurred in spite of rising corn and soybean prices since 2002 associated with Minnesota's biofuel industry and increased foreign demand for these commodities, which indicates that the long-term nature of the CRP and CREP contracts are critical for maintaining the conversions of cropland to grassland or forest cover while providing stable farm income.