Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age

Paladini, D.; Pastore, G.; Cavallaro, A; Massaro, Maria; Nappi, Carmine

doi:10.1002/uog.12506

Cited by 69 publications

(86 citation statements)

References 10 publications

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“…25,26 However, these signs might be subtle or missing. 27,28 The presence of a normal CC and its biometry has been assessed by transabdominal and transvaginal 2D and 3D sonography and with fetal MR imaging from 18 weeks onward. 10,17,[29][30][31][32][33] Indirect appreciation of the developing CC will be seen by demonstration of the pericallosal artery and its branches.…”

Section: Discussionmentioning

confidence: 99%

Sonographic Development of the Pericallosal Vascularization in the First and Early Second Trimester of Pregnancy

Keersmaecker

Pottel

Naulaers³

et al. 2018

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Anomalies of the corpus callosum are rare. Routine scanning in midtrimester of the pregnancy often fails to identify defective development. The purpose of the study was to identify the pericallosal artery and all its main branching arteries during early gestation from the first trimester onward, to measure the length of the pericallosal artery during its development, and to establish a normal vascular map for each week of development.

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Section: Discussionmentioning

confidence: 99%

Sonographic Development of the Pericallosal Vascularization in the First and Early Second Trimester of Pregnancy

Keersmaecker

Pottel

Naulaers³

et al. 2018

AJNR Am J Neuroradiol

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“…The power Doppler examination of these vessels has been mostly reported in fetuses with suspected callosal agenesis using 2D ultrasound with the aim of confirming the sonographic findings [8]. In fact, due to the close anatomical relationship between the corpus callosum itself and its feeding vessels, the pericallosal arteries are not sonographically detectable in fetuses with complete callosal agenesis.…”

Section: Discussionmentioning

confidence: 99%

Demonstration of the Pericallosal Artery at 11-13 Weeks of Gestation Using 3D Ultrasound

Conturso

Contro²,

Bellussi³

et al. 2014

Fetal Diagn Ther

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Objective: To assess the sonographic visualization of the pericallosal arteries in normal fetuses at 11-13 weeks of gestation using 3D ultrasound. Methods: We prospectively enrolled women with a singleton pregnancy undergoing ultrasound at 11-13 weeks of gestation. A 3D volume with high-definition power Doppler was acquired starting from the sagittal view of the fetal head and stored in the spatiotemporal image correlation mode. The images of the pericallosal arteries were assigned a score of 0 (no visualization), 1 (visualization of the origin) or 2 (visualization of the whole course). A follow-up scan was performed in all cases at 20 weeks of gestation to assess the presence of the corpus callosum. Results: 70 patients were included and the pericallosal arteries were sonographically detectable in all cases. Image scores of 1 and 2 were obtained in 8 and 62 cases, respectively. The whole length of the vessel was between 3.5 and 4.5 mm. The vast majority of those with a score of 2 were beyond 12 completed weeks of gestation. All fetuses showed a normal corpus callosum at midtrimester and no abnormal brain findings after birth. Conclusions: The pericallosal arteries are sonographically visible since the first trimester in 3D ultrasound scans of fetuses found to have a normal corpus callosum at follow-up.

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“…Paladini et al, in the retrospective analysis of fetuses with CC defects, revealed that in most cases the abovementioned ultrasound signs were not present < 24 weeks of gestation. On the other hand, they were more evident with the advancing gestational age: VM was present in 74.3% and colpocephaly in 68.6% of the cases in the late second trimester [22]. Prediction of the long-term pregnancy outcome and neurodevelopment in childhood depends on the type of defect and presence of the associated anomalies.…”

Section: Agenesis Of Corpus Callosum (Acc)mentioning

confidence: 99%

“…On the other hand, the prognosis for fetuses with ACC and other anomalies remains poor. To sum up, prenatal detection of CC malformations presents a challenge due to the fact that sonographic signs may be very subtle or appear after the second-trimester scan [22]. Proper management requires thorough neurosonographic evaluation of CNS.…”

Section: Agenesis Of Corpus Callosum (Acc)mentioning

confidence: 99%

Three-dimensional neurosonography — a novel field in fetal medicine

Lipa¹,

Pooh²,

Wielgoś³

2017

Ginekol Pol

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Neurosonography is a promising technique for prenatal diagnosis, combining features of ultrasound imaging with fetal neurology. The brain is a three-dimensional structure, therefore observing brain structure in the three basic planes (sagittal, coronal and axial) is mandatory. The anterior fontanelle and sagittal suture may serve as acoustic ultrasound windows in the transvaginal brain scan, allowing to obtain high-resolution neuroimages of the intracranial structures. Furthermore, three-dimensional (3D) ultrasound combined with the transvaginal brain approach provides detailed and sophisticated neuroimages. Three orthogonal planes of the brain, tomographic ultrasound imaging (TUI) and other off-line approaches (e.g. volume contrast imaging (VCI) or HDlive silhouette imaging) may be obtained from a single 3D dataset. 3D Doppler ultrasound enables visualization of the intracerebral vascularity, allowing to obtain more precise information on cerebral perfusion. Various abnormal brain conditions, including ventriculomegaly, agenesis of the corpus callosum, posterior fossa abnormalities and others, can be well-demonstrated. Due to high rates of the associated anomalies and uncertain prognosis, any suspicion of CNS abnormalities shall imply detailed ultrasonographic evaluation of the fetal anatomy to exclude the associated anomalies. Despite a growing number of neuroimaging modalities, prenatal counselling remains a challenge as prediction of brain functionality and the neurological prognosis often remain uncertain. New investigations on the relations between various migration disorders and gene mutations, as well as recent clinical research on the relations between neuroimaging detection of local migration disorders using sophisticated imaging technologies and the postnatal neurological prognosis will contribute to the development of maternal-fetal medicine as well as pediatric neurology.

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Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age

Abstract: Objectives

Cited by 69 publications

References 10 publications

Sonographic Development of the Pericallosal Vascularization in the First and Early Second Trimester of Pregnancy

Sonographic Development of the Pericallosal Vascularization in the First and Early Second Trimester of Pregnancy

Demonstration of the Pericallosal Artery at 11-13 Weeks of Gestation Using 3D Ultrasound

Three-dimensional neurosonography — a novel field in fetal medicine

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