Abstract:Hypothesis: Decreased localization of L-type Ca 2þ channels (LTCCs) and ryanodine receptors (RyRs) to TTs in atrial cells results in increased propensity for arrhythmogenic CaT alternans. Methods: Using a human atrial cell model from Grandi et al. incorporating chronic AF remodeling, the effects of ion channel redistribution were evaluated by moving 0-100% of TT ionic currents to the sub-sarcolemmal compartment (SL). Ryanodine receptor (RyR) redistribution was also tested by moving 0-100% of RyR release from t… Show more
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