2018
DOI: 10.1038/s41467-018-06154-9
|View full text |Cite
|
Sign up to set email alerts
|

Age structure landscapes emerge from the equilibrium between aging and rejuvenation in bacterial populations

Abstract: The physiological asymmetry between daughters of a mother bacterium is produced by the inheritance of either old poles, carrying non-genetic damage, or newly synthesized poles. However, as bacteria display long-term growth stability leading to physiological immortality, there is controversy on whether asymmetry corresponds to aging. Here we show that deterministic age structure landscapes emerge from physiologically immortal bacterial lineages. Through single-cell microscopy and microfluidic techniques, we dem… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

5
71
1

Year Published

2019
2019
2023
2023

Publication Types

Select...
4
2

Relationship

1
5

Authors

Journals

citations
Cited by 43 publications
(77 citation statements)
references
References 34 publications
5
71
1
Order By: Relevance
“…Under such conditions, our previous studies have shown that new and old daughters display physiological asymmetry and long-term growth stability [17]. We confirmed these results in the present experiments, observing that new daughters displayed significantly faster elongation rates when compared with old daughters (Fig 1A), a distinction that remained constant over time.…”
Section: Functionally Immortal Bacterial Lineages Display Damage Accusupporting
confidence: 92%
See 4 more Smart Citations
“…Under such conditions, our previous studies have shown that new and old daughters display physiological asymmetry and long-term growth stability [17]. We confirmed these results in the present experiments, observing that new daughters displayed significantly faster elongation rates when compared with old daughters (Fig 1A), a distinction that remained constant over time.…”
Section: Functionally Immortal Bacterial Lineages Display Damage Accusupporting
confidence: 92%
“…Bacterial populations display phenotypic variation arising from asymmetric cell divisions, an evolutionarily advantageous strategy for increasing the efficiency of natural selection [18]. Previous studies have shown that, as a consequence of asymmetric cellular divisions, aging and rejuvenating bacterial lineages stabilize at distinct states of physiological equilibrium [7,17,23]. While in equilibrium, these lineages remain functionally immortal.…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations